Hypoplasia of the Parabrachial/Kölliker-Fuse Complex in Perinatal Death

Lavezzi, Anna Maria; Ottaviani, Giulia; Rossi, Lino; Matturri, Luigi

doi:10.1159/000078310

Cited by 37 publications

(23 citation statements)

References 20 publications

(39 reference statements)

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“…In our previous studies, we have reported the implication of the Kölliker-Fuse nucleus in the pathogenesis of SIDS and that its hypoplasia, like other brainstem alterations, is significantly associated with maternal smoking in pregnancy [5,8]. In this case however the mother admitted no history of cigarette smoking.…”

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confidence: 57%

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Sudden unexpected postnatal collapse at 20 hours from birth during skin-to-skin care related to brainstem developmental alterations – a case report

Lavezzi¹,

Piscioli²,

Pusiol³

2017

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confidence: 57%

“…oscillations of pO 2 , pCO 2 and pH [5][6][7][8]. This activity is also sustained by the chemo receptor nuclei, to which the retrotrapezoid nucleus and the raphe obscurus nucleus belong [3,9].…”

mentioning

confidence: 99%

Sudden unexpected postnatal collapse at 20 hours from birth during skin-to-skin care related to brainstem developmental alterations – a case report

Lavezzi¹,

Piscioli²,

Pusiol³

2017

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“…Another hypothesis is that the activity of the peripheral chemoreceptor, particularly the carotid body, increases dramatically as blood flow decreases [24], thereby overwhelming the inhibitory effects of the lateral pons. However, a recent study has demonstrated that in about a third of stillbirths there is congenital hypodevelopment of both the lung and the arcuate nucleus [25,26]. It was postulated that in these cases the arcuate nucleus hypoplasia could exert a negative effect on respiratory movements in utero and therefore on lung development.…”

Section: Chemoreception In the Fetusmentioning

confidence: 99%

Peripheral Chemoreceptors and Sudden Infant Death Syndrome: A Wide Open Problem

Matturri¹,

Ottaviani²,

Lavezzi³

et al. 2005

CCR

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This review will focus on the basic mechanisms of the peripheral chemoreceptors elicited by studies on mature chemoreceptors and on the alterations observed in these structures related to sudden infant death. The integrated response of the peripheral chemoreceptors consists of the transduction of alterations in the chemical milieu, regulating the temperature of their environment to alterations in cardiovascular and respiratory performance. Over the years, much has been written about the relative importance of the carotid and aortic bodies in the peripheral chemoreceptor response, and it is therefore worthwhile to consider the current state-of-the-art on that issue. Several lines of evidence have suggested that abnormalities in chemoreception may play a role in central hypoventilation syndromes. The sudden infant death syndrome (SIDS) involves a failure of respiration and affects infants in their early postnatal months. Unstable respiratory activity during sleep, prolonged sleep apnea, and oropharyngeal/laryngeal dysfunction induced by liquid stimulation of the upper airways have been postulated to be implicated in its genesis. It has also been found that in comparison with normal infants, infants suffering from the "aborted syndrome" (near-miss infants) are hypoventilated during quiet sleep, and have an impaired ventilatory response to carbon dioxide breathing.

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“…A histopathological substrate should be searched for in a wide neuropathology field, including the brainstem nuclei, the cerebellum (cortex and deep nuclei), and the cardiac conduction system, subjected to strict autonomic control [2,10,11,23,26,28].…”

Section: Introductionmentioning

confidence: 99%

Guidelines for neuropathologic diagnostics of perinatal unexpected loss and sudden infant death syndrome (SIDS)—a technical protocol

2007

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In light of the growing information on the pathophysiology and clinical aspects of unexpected perinatal loss and sudden infant death syndrome (SIDS), a novel approach to the inherent problems by pathologists has become necessary. Herein, we propose an up-to-date protocol for accurate examination of the central autonomic nervous system and of the cardiac conduction system, which can encompass morphological and/or functional abnormalities of reliable epicritical value in unexplained perinatal loss and SIDS, particularly in those cases (still quite numerous) lacking adequate clinical documentation. Anatomo-pathologic examination of the central autonomic nervous system includes an in-depth study on histological serial sections of the brainstem, cerebellum, and spinal cord, where the main structures participating in control of the vital functions are located. For the histological study of the cardiac conductions system, serial sections were obtained from two blocks, including the sino-atrial node and the atrio-ventricular system, respectively. This type of updated investigation is yielding important arguments for a broader discussion of the pathogenesis of unexpected stillbirth, early neonatal death, and SIDS, besides allowing a more complete forensic-medical documentation of individual cases.

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Hypoplasia of the Parabrachial/Kölliker-Fuse Complex in Perinatal Death

Cited by 37 publications

References 20 publications

Sudden unexpected postnatal collapse at 20 hours from birth during skin-to-skin care related to brainstem developmental alterations – a case report

Sudden unexpected postnatal collapse at 20 hours from birth during skin-to-skin care related to brainstem developmental alterations – a case report

Peripheral Chemoreceptors and Sudden Infant Death Syndrome: A Wide Open Problem

Guidelines for neuropathologic diagnostics of perinatal unexpected loss and sudden infant death syndrome (SIDS)—a technical protocol

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