Hypoplasia of the maxillary, sphenoid and frontal sinus in the patient with nasopharyngeal branchial cyst: Case Repor

Ghazizade, Matin; Asadi, Mahboobe; Darbani, Pouyan

doi:10.5455/jrmds.2016446

J Res Med Den Sci

2016

DOI: 10.5455/jrmds.2016446

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Hypoplasia of the maxillary, sphenoid and frontal sinus in the patient with nasopharyngeal branchial cyst: Case Repor

Matin Ghazizade¹,

Mahboobe Asadi²,

Pouyan Darbani³

Abstract: Cystic lesions of the nasopharynx are typically benign and often found incidentally. The authors report a case of nasopharyngeal branchial cyst in a patient with hypoplastic maxillary, sphenoid and frontal sinuses. The patient underwent transnasal endoscopic resection of the cyst.Results showed that in the management of nasopharyngeal branchial cyst it is important to clarify the anatomic details of the paranasal sinuses with Computed tomography (CT) scan respect to correct diagnosis and appropriate surgical p… Show more

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Effect of Areca Nut Consumption on Hypoxia-inducible Factor-1 Alfa Expression in Patients with Oral Squamous Cell Carcinoma

Agarwal¹,

Chauhan²,

Prasad³

et al. 2017

Indian Journal of Medical Biochemistry

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prognosis. This calls for widespread awareness programs regarding the deleterious effects of areca nut chewing among the general population.Keywords: Arecoline, Hypoxia-inducible factor-1 alfa, Oral squamous cell carcinoma.How to cite this article: Prasad J, Goswami B, Agarwal K, Mehra P, Kumar S, Pahuja BK, Chauhan A, Ahirwar AK. Effect of Areca Nut Consumption on Hypoxia-inducible Factor-1 Alfa Expression in Patients with Oral Squamous Cell Carcinoma. Indian J Med Biochem 2017;21(2):81-85. Source of support: Nil Conflict of interest: None INTRODUCTIONOral squamous cell carcinoma is a common malignancy affecting Asians.1 Among the various known risk factors for OSCC, areca nut chewing is a common occurrence in countries, such as India. 2 The increasing incidence of consumption of areca nut has nullified the awareness programs that have only targeted tobacco as a major risk factor. The primary constituent of areca nut-alkaloid arecoline-has been identified as a group I carcinogen. Arecoline has genotoxic, cytotoxic, and mutagenic effect on various cells. 3 Studies have implicated areca nut chewing as a cause for submucous fibrosis, oral cancer, hepatocellular carcinoma, carcinoma of cervix, lung, and stomach. 4 Areca nut is either consumed in isolation or taken in the form of betel quid along with tobacco, catechu, lime, and sweeteners. This augments the carcinogenicity due to the effect of lime and betel leaf component-safrole. Hypoxia-inducible factor-1 alfa is a key transcription factor induced by hypoxia and activates a transcription program that promotes the survival of cells in a hypoxic state. Studies have indicated a plausible role of arecoline in HIF expression through reactive oxygen species (ROS) pathway. 6The present study was planned to evaluate the effect of areca nut consumption on HIF-1α levels. Our hypothesis is that arecoline leads to stabilization of HIF-1α even under normoxic conditions, thereby leading to more aggressive tumors in areca nut chewers. ABSTRACTIntroduction: Oral squamous cell carcinoma (OSCC) is a major health problem in Southeast Asia, including India. Areca nut chewing is a major health hazard in India, which has been implicated in the etiology of OSCC. Hypoxia-inducible factor-1 (HIF-1) is a major transcription factor involved in adaptation under hypoxic condition, a common finding in solid tumors. The present study was conducted to evaluate the effect of different habits including areca nut chewing on HIF-1 expression in patients with OSCC.

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Effect of Areca Nut Consumption on Hypoxia-inducible Factor-1 Alfa Expression in Patients with Oral Squamous Cell Carcinoma

Agarwal¹,

Chauhan²,

Prasad³

et al. 2017

Indian Journal of Medical Biochemistry

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Hypoplasia of the maxillary, sphenoid and frontal sinus in the patient with nasopharyngeal branchial cyst: Case Repor

Cited by 1 publication

References 7 publications

Effect of Areca Nut Consumption on Hypoxia-inducible Factor-1 Alfa Expression in Patients with Oral Squamous Cell Carcinoma

Effect of Areca Nut Consumption on Hypoxia-inducible Factor-1 Alfa Expression in Patients with Oral Squamous Cell Carcinoma

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