Hypoplasia of the Cerebellar Vermis and Cognitive Deficits in Survivors of Childhood Leukemia

Ciesielski, Kristina T.; Yanofsky, Rochelle; Ludwig, R.; Hill, Dina E.; Hart, Blaine L.; Astur, Robert S.; Snyder, T.

doi:10.1001/archneur.1994.00540220031012

Cited by 53 publications

(26 citation statements)

References 57 publications

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“…In contrast to these findings, Piven et al used MRI to examine the cerebella of 36 autistic and 35 control subjects and found no difference in the size of cerebellar lobules I‐V and VI‐VII or in the total cerebellar volume after being adjusted for gender, performance IQ and TBV (Piven et al, ). These findings accord with several previous studies (Ritvo, ; Filipek et al, ; Holttum et al, ; Kleiman et al, ; Piven et al, ; Ciesielski et al, ; Schaefer et al, ). Hashimoto et al reported hypoplasia not only of the neocerebellum but also of lobules I‐V and VIII‐X, the pons, midbrain, and medulla, implying that there is no selective neocerebellar abnormality in autism (Hashimoto et al, ; Hashimoto et al, ).…”

Section: Cerebellumsupporting

confidence: 93%

Neuroanatomical variation in autism spectrum disorder: A comprehensive review

et al. 2016

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Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impairments in socialization, communication, and behavior. Many investigators have described the anatomical abnormalities in autistic brains, in an attempt to correlate them with the manifestations of ASD. Herein, we reviewed all the available literature about the neuroanatomical findings in ASD available via "PubMed" and "Google Scholar." References found in review articles were also searched manually. There was substantial discrepancy throughout the literature regarding the reported presence and significance of neuroanatomical findings in ASD, and this is thoroughly discussed in the present review.

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Section: Cerebellumsupporting

confidence: 93%

Neuroanatomical variation in autism spectrum disorder: A comprehensive review

et al. 2016

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“…23 Similarly, cerebellar damage owing to infratentorial infarcts, radiation, and chemotherapy for leukemia reveals that cognitive assessment in children and young adults is impaired and unlikely to improve. 24,25 Recently, Riva and Giorgi considered the cerebellum as contributing to higher functions during development; the authors described 26 children who had undergone surgery for removal of a cerebellar hemisphere or vermal tumors. 26 Levisohn et al also considered the neuropsychologic consequences of cerebellar tumors in 19 children who did not receive either cranial irradiation or methotrexate chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Epilepsy, Intelligence, and Psychiatric Disorders in Patients With Cerebellar Hypoplasia

et al. 2003

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The cerebellum is involved in motor and cognitive functions and behavior. Its role in controlling epileptic seizures has been demonstrated in the literature. Genetic factors can enhance epilepsy susceptibility when the cerebellum is damaged. We examined the occurrence and features of epilepsy, intelligence, and psychiatric disorders in 28 patients with cerebellar hypoplasia. We compared patients with (10; 35.7%) and without (18; 64.3%) epilepsy. The statistical evaluation showed a significant prevalence of familial antecedents for seizures in patients with epilepsy (P < .01); cerebral associated lesions and type of cerebellar hypoplasia did not influence the occurrence of epilepsy, which was partial in 80% of cases. Profound mental retardation prevailed in patients with epilepsy (P < .05). Both mental retardation (75%) and pervasive developmental disorders (17.8%) prevailed in our cases with respect to the general population (P < .000). Cerebellar hypoplasia in our sample seems to be an important risk factor for the occurrence of epilepsy, mental retardation, and psychiatric disorders.

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“…Magnetic resonance imaging (MRI) or cranial computerised tomography (CT) scans were found diffusely modi ed in proportion ranging from 15% of the subjects (Paakko, Vainionpaa, Table 1 Radiation effects Lanning, Laitinen, & Pyhtinen, 1992) through 51-52% (Hertzberg et al, 1997;Kingma, Mooyaart, Kamps, Nieuwenhuizen, & Wilmink, 1993). Coexistence of cerebellar hypoplasia and visual-motor co-ordination were also found in survivors of ALL (Ciesielski et al, 1994). Yet, CT and MRI techniques only visualise the anatomical sequelae of the brain insult.…”

Section: Global Brain Levelmentioning

confidence: 99%

“…For example, on the WISC-R, they performed poorly on Arithmetic, Digit Span, and Coding subtests included in the distractibility factor ( Paakko et al (1992); Kingma et al (1993); Matsumoto et al (1995); Hertzberg et al (1997) 2. Ciesielski et al (1994) Electroencephalography (EEG) 1. Long-term effects: decreased power in children with CRT and MTX…”

Section: Neuropsychological Impairmentsmentioning

confidence: 99%

A comprehensive model of the development of mental handicap in children treated for acute lymphoblastic leukaemia: A synthesis of the literature

Robaey

Dobkin

Leclerc

et al. 2000

International Journal of Behavioral Development

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Most clinical studies addressing sequelae in children with leukaemia are not theory-driven. Nonetheless, the role of different mediating biological (e.g. cranial irradiation, chemotherapy) and psychosocial variables (e.g. family functioning) has been empirically acknowledged. In these studies, a cause-effect relationship between biological variables and cognitive deficits, sometimes complex due to multiple agents, has been hypothesised. As for the psychosocial consequences, adaptation to the cancer-related stress has been the main focus, at both the individual and family levels. In this paper, we advocate the use of a global model for the development of handicap, derived from the International Classification of Impairments, Disabilities and Handicaps (ICIDH) by the World Health Organisation. This revised model proposes that handicap is the result of complex interactions between the characteristics of a person’s impairment, disabilities, and the characteristics of the environment. At each of these levels, risk/resilience factors are defined. This means that depending on the environmental obstacles they face, persons with an impairment or a disability may or may not experience a situation creating a handicap which is no longer seen as a stable status resulting from a disease to which the individual must adapt. By reviewing animal and clinical studies, current knowledge pertaining to leukaemia sequelae are integrated into the different levels defined by the model: organic impairment, disabilities, environmental obstacles, and handicap situation. Practical implications for research, policies, and individual treatments, and comparisons with existing models, are also outlined.

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Hypoplasia of the Cerebellar Vermis and Cognitive Deficits in Survivors of Childhood Leukemia

Cited by 53 publications

References 57 publications

Neuroanatomical variation in autism spectrum disorder: A comprehensive review

Neuroanatomical variation in autism spectrum disorder: A comprehensive review

Epilepsy, Intelligence, and Psychiatric Disorders in Patients With Cerebellar Hypoplasia

A comprehensive model of the development of mental handicap in children treated for acute lymphoblastic leukaemia: A synthesis of the literature

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