Hypopituitarism—needs modern individualized treatment

Olsson, Daniel S; Bengtsson, Bengt‐Åke

doi:10.1007/s12020-016-1211-3

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…Another study of Van Bunderen et al 35 noted an increased mortality rate in treated growth hormone–deficient adults when compared to the general population, but only in women. Olsson and Bengtsson 36 stated that these differences might be due to the notion that women with hypopituitarism are treated less optimal than men, such as a 15% higher replacement dose of glucocorticoids per kg. Treatment imperfections regarding women have been known for other chronic illnesses.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Impaired neuropsychological functioning in patients with hypopituitarism

Slagboom

Deijen

Bunderen

et al. 2020

Endocrino Diabet & Metabol

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Background Treatment of pituitary pathology mostly does not result in complete recovery of impairment in cognitive functioning. The primary aim of the current study was to assess cognitive impairment in patients with stable replacement therapy for hypopituitarism during the last 6 months prior to inclusion. It was expected that patients showed subjective and objective subnormal scores on neuropsychological functioning. Methods Forty‐two patients (40% men, 49 ± 15 years) treated for hypopituitarism conducted a neuropsychological test battery, including the Cognitive Failures Questionnaire (CFQ), 15‐Word test (15‐WT), Cambridge Neuropsychological Test Automated Battery (CANTAB) Motor Screening Task (MOT), Spatial Working Memory (SWM) and Affective Go/No‐go (AGN). Results were compared to reference values of healthy norm groups. Results Male and female participants scored significantly worse on the CFQ (P < .01, d = 0.91‐4.09) and AGN mean correct latency (P < .01, d = 1.66 and 1.29, respectively). Female participants scored significantly worse on 15‐WT direct recall (P = .01, d = 0.66), 15‐WT delayed recall (P = .01, d = 0.79), SWM total errors (P = .05, d = 0.41), SWM strategy (P = .04, d = 0.43), AGN errors of commission (P = .02, d = 0.56) and omission (P = .04, d = 0.41). Conclusion This study shows that subjective cognitive functioning is worse in patients treated for hypopituitarism compared to reference data. Also, female participants treated for hypopituitarism score worse on objective aspects of memory and executive functioning compared to reference data. Besides worse focus attention, this objective cognitive impairment was not found in male participants. It is recommended to conduct additional research, which focuses on the design and evaluation of a cognitive remediation therapy, aimed at compensation of impairments in different aspects of memory and executive functioning.

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Section: Discussion/conclusionmentioning

confidence: 99%

Impaired neuropsychological functioning in patients with hypopituitarism

Slagboom

Deijen

Bunderen

et al. 2020

Endocrino Diabet & Metabol

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“…[ 7 ] Previous studies have suggested that diabetes can promote both tumorigenesis and tumor progression. [ 9 – 11 ] It is well known that diabetes is a risk factor of cancer. A large number of epidemiological studies have shown the predictive role of diabetes in the prognosis of many types of cancers, such as breast cancer, ovarian cancer, and colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

The association between diabetes/hyperglycemia and the prognosis of cervical cancer patients

et al. 2017

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“…Treatment and management of hypopituitarism currently focuses on normalization of hormonal disturbances, rather than functional outcomes such as well-being, mental impairment and QoL [ 67 , 68 ]. As a consequence, discrepancies may arise between patients expected versus actual well-being.…”

Section: Discussionmentioning

confidence: 99%

Psychological well-being and illness perceptions in patients with hypopituitarism

et al. 2021

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Objective The primary aim of the current study was to objectify a spectrum of persisting subjective psychological complaints in patients with hypopituitarism, at least six months after normalizing of the hormonal disturbances. Also, gender differences on these outcomes were investigated. The secondary aim was to identify illness perceptions and causal attributions within this patient group. Methods A total of 42 adult participants (60% females) with treated hypopituitarism once filled out a number of psychological questionnaires. The Profile of Mood States (POMS) and the Hospital Anxiety and Depression Scale (HADS) assessed mood and the Symptom Checklist-90 (SCL-90) and the Work and Social Adjustment Scale (WSAS) assessed well-being. Illness perceptions were identified using the Illness Perceptions Questionnaire-Brief Dutch Language Version (IPQ-B DLV) and causal attributions by using the Causal Attribution List (CAL). Patient outcomes were compared to reference values of healthy norm groups. Results Participants scored significantly worse on the POMS depression, anger, fatigue and tension subscales, the SCL-90 psychoneuroticism, depression, inadequacy of thinking and acting and sleeping problems subscales and all subscales of the WSAS when compared to reference data. Women also scored worse on depression (HADS) and somatic symptoms (SCL-90). Compared to other illnesses, patients with hypopituitarism have more negative and realistic illness perceptions on consequences, timeline, identity and emotions. Participants attributed their complaints more to physical causes than psychological causes. Conclusion Despite normalization of hormonal disturbances, patients with hypopituitarism in general can still experience problems during daily living, such as negative mood states and a decreased psychological well-being.

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Hypopituitarism—needs modern individualized treatment

Cited by 4 publications

References 19 publications

Impaired neuropsychological functioning in patients with hypopituitarism

Impaired neuropsychological functioning in patients with hypopituitarism

The association between diabetes/hyperglycemia and the prognosis of cervical cancer patients

Psychological well-being and illness perceptions in patients with hypopituitarism

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