Hypopituitarism in normal-pressure hydrocephalus.

Barber, S G; Garvan, N

doi:10.1136/bmj.1.6170.1039

Cited by 12 publications

(8 citation statements)

References 3 publications

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“…Sellar abnormalities were easily detected by conventional tomography, and obstructive hydrocephalus was shown by computed tomography despite the absence of any neurological and ophthalmological symptom or sign. Although hydrocephalus usually presents with a prominent neuropsychiatric syndrome, endocrine manifestations may occur, including primary or secondary arnenorrhoea, stunted growth, delayed or sometimes precocious puberty; obesity is frequently associated (Kahana et al 1962;Goldzieher & Hardy, 1970;Fiedler & Krieger 1975;Hier & Wiehl 1977;Barber & Garvan, 1979;Dempsey et ul. 1983).…”

Section: Discussionmentioning

confidence: 99%

Hypothalamic disease presenting as amenorrhoea: value of computed tomography

Ferrari¹,

Crosignani²

1985

BJOG

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Five women presenting with amenorrhoea (three with secondary amenorrhoea and galactorrhoea, and two with primary amenorrhoea) were shown to have suprasellar abnormalities by computed tomography. Organic hypothalamic disease was confirmed at surgery (craniopharyngioma in three, intra-and suprasellar Rathke's cleft cyst in one, aqueductal stenosis and suprasellar arachnoid cyst in one). Moderate hyperprolactinaemia was present in the first four, while the last had isolated gonadotrophin deficiency of hypothalamic origin.

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Section: Discussionmentioning

confidence: 99%

Hypothalamic disease presenting as amenorrhoea: value of computed tomography

Ferrari¹,

Crosignani²

1985

BJOG

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“…The most common manifestations of endocrinological disturbances are hypothalamic-hypophyseal-gonadal axis impairment such as pre- cocious or delayed puberty which is often associated with obesity and amenorrhea in girls and young women (11). The precise mechanism of the association of amenorrhea and hydrocephalus is not well-known (3,5,7,(12)(13)(14). Jawadi et al (5) described secondary amenorrhea in a patient with hypothalamic astrocytoma.…”

Section: Discussionmentioning

confidence: 99%

Secondary Amenorrhea Caused by Hydrocephalus Due to Aqueductal Stenosis: Report of Two Cases

Lee

Kim

et al. 2001

J Korean Med Sci

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Amenorrhea is rarely presented as a manifestation of endocrinological disturbances in patients of chronic hydrocephalus. We describe two cases of secondary amenorrhea caused by hydrocephalus due to aqueductal stenosis. Two female patients of age 30 and 20 yr presented with amenorrhea and increasing headache. Magnetic resonance images revealed marked, noncommunicating hydrocephalus without any tumorous lesion. In one patient, emergent extraventricular drainage was necessary because of progressive neurological deterioration. Each patient underwent surgical intervention for the hydrocephalus-ventriculoperitoneal shunt and endoscopic third ventriculostomy. Both resumed normal menstruation continuing so far with further normal menstrual bleeding. These two cases and others reported in the literature indicated that the surgical intervention for hydrocephalus resolves amenorrhea in all the cases of amenorrhea due to hydrocephalus. The suspected role of the surgery is the correction of increased intracranial pressure, which is an important pathogenetic factor in the development of amenorrhea.

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“…The most common manifestations of endocrinological disturbances are hypothalamic-hypophysial-gonadal axis impairments, such as precocious or delayed puberty, often associated with obesity and amenorrhea in girls and young women [12]. The precise mechanism of the association between amenorrhea and hydrocephalus is not well understood [3,4,6,13,14,15]. Jawadi et al [4] described secondary amenorrhea in a patient with hypothalamic astrocytoma.…”

Section: Discussionmentioning

confidence: 99%

“…Other forms of hypopituitarism associated with normal-pressure hydrocephalus have been reported by Barber and Garvan [13] in 1978 and 1979, with no information on pituitary function after neurosurgical treatment.…”

Section: Introductionmentioning

confidence: 99%

Hypopituitarism due to Hydrocephalus: Case Report and Review of the Literature

Pinto

Neto²,

Rocha

et al. 2011

Pediatr Neurosurg

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Introduction: Although rare, chronic hydrocephalus may cause amenorrhea and delayed puberty associated with obesity as the main endocrine manifestations. Since the first operation carried out in 1950 on a patient with amenorrhea and hydrocephalus, fewer than 30 patients with these features have been reported. Case Report: Our patient represents a teenage case of primary amenorrhea, partial adrenal insufficiency and adult growth hormone deficiency caused by hydrocephalus due to aqueductal stenosis. Our English-language literature search for similar well-documented cases yielded less than 30 cases. Our management consisted of endoscopic third ventriculostomy, which resulted in regular menstrual cycles and normalization of somato- and adrenocorticotropic axes. Discussion: This is a rare case of a 20-year-old woman with primary amenorrhea caused by hydrocephalus due to aqueductal stenosis. Neurosurgical treatment produced relief in hypothalamic hydrodynamics tension, allowing recovery of hormonal function and restoring normal menstrual cycles.

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Hypopituitarism in normal-pressure hydrocephalus.

Cited by 12 publications

References 3 publications

Hypothalamic disease presenting as amenorrhoea: value of computed tomography

Hypothalamic disease presenting as amenorrhoea: value of computed tomography

Secondary Amenorrhea Caused by Hydrocephalus Due to Aqueductal Stenosis: Report of Two Cases

Hypopituitarism due to Hydrocephalus: Case Report and Review of the Literature

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