Hypopigmentation After Triamcinolone Injection for de Quervain Tenosynovitis

Liang, Jing; McElroy, Kevin

doi:10.1097/phm.0b013e318269ebdc

Cited by 24 publications

(19 citation statements)

References 1 publication

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“…However, to the best of our knowledge, development of the hypopigmented linear streak apart from the original site of application has rarely been reported. Only a limited number of reports for linear atrophy and hypopigmentation after intradermal or intra‐articular injections with high concentrations of triamcinolone have been reported in the literature . As possible mechanisms for hypopigmentation at the primarily applied site, corticosteroid may alter melanocyte function by inhibiting prostaglandin or cytokine production in various epidermal cells, and significant decreases of melanin pigment in our case support these perspectives.…”

supporting

confidence: 72%

Linear extensions of hypopigmentation as a side effect of topical corticosteroid application

Kwon

Suh

2016

Int J Dermatology

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supporting

confidence: 72%

Linear extensions of hypopigmentation as a side effect of topical corticosteroid application

Kwon

Suh

2016

Int J Dermatology

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“…Hence for lesions close to the skin surface, especially in hyperpigmented patient triamcinolone should be avoided, instead TS with smaller particles and less tendency to aggregate should be preferred. [10] Various side effects of topical steroids are depicted in Figures 1–18.…”

Section: Suppression Of the Hypothalamic-pituitary-adrenal Axismentioning

confidence: 99%

Side-effects of topical steroids: A long overdue revisit

Coondoo

Phiske

Verma

et al. 2014

Indian Dermatol Online J

278

193

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The introduction of topical steroids (TS) of varying potency have rendered the therapy of inflammatory cutaneous disorders more effective and less time-consuming. However the usefulness of these has become a double edged sword with constantly rising instances of abuse and misuse leading to serious local, systemic and psychological side effects. These side effects occur more with TS of higher potency and on particular areas of the body like face and genitalia. The article reviews the side effects of TS with special mention about peadiatric age group, also includes the measures for preventing the side effects.

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“…Skin changes may occur after injection of different steroids . However, depigmentation was more likely with triamcinolone acetonide compared with other steroids . The less soluble (longer‐acting) preparations have a more detrimental effect on surrounding soft tissues, with triamcinolone acetonide being the least soluble injectable steroid preparation and having the longest‐lasting effect.…”

Section: Discussionmentioning

confidence: 99%

Reflectance confocal microscopy and histological features of depigmentation after local corticosteroid injection

Zhang

Liu

et al. 2019

Skin Res Technol

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Background Clinically, depigmentation after local corticosteroid injection is not rare. But there are less articles about its reflectance confocal microscopy (RCM) and histological features. This study aimed to define the RCM features and histopathologic findings of hypopigmentation after local corticosteroid injection and to analyze the correlations between the above two methods. Methods Forty cases with hypopigmentation after local corticosteroid injection were used to analyze the clinical and RCM features. Subsequently, for 20 of 40, an excision biopsy of the same imaged areas for histopathologic examination was executed. Results Our results showed that all 40 cases had round or ellipse hypopigmented macules with obscure boundary and 26 of 40 lesions’ long diameter went along limbs. The RCM features and the histological findings revealed all patients had variable degrees of epidermal thinning, flattening rete ridges, reduced melanin, and no inflammatory cell infiltration. MART‐1 analysis revealed the number of melanocytes was normal but with no or less melanin by Fontana‐Masson staining. Conclusions Depigmentation after local corticosteroid injection was a kind of disease with intact melanocytes, whose function was impaired. RCM features offer a high consistency with histopathologic findings. It thus constitutes a promising adjuvant tool for its diagnosis and for therapeutic follow‐up.

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Hypopigmentation After Triamcinolone Injection for de Quervain Tenosynovitis

Cited by 24 publications

References 1 publication

Linear extensions of hypopigmentation as a side effect of topical corticosteroid application

Linear extensions of hypopigmentation as a side effect of topical corticosteroid application

Side-effects of topical steroids: A long overdue revisit

Reflectance confocal microscopy and histological features of depigmentation after local corticosteroid injection

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