Hypophosphatemia in the Alcoholic

Knöchel, James P.

doi:10.1001/archinte.1980.00330170029018

Cited by 44 publications

(12 citation statements)

References 24 publications

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“…The refeeding syndrome is characterised by electrolyte depletion, fluid shifts and glucose derangements that occur in malnourished patients upon reinstitution nutrition orally, enterally, or parentrally (7). An advantage of our study group is that malnutrition was not confounded by coexistence of chronic alcohol consumption, a known risk factor for HP [13]. Chronic alcohol abuse is rare in the Israeli population, and in none of our cases, was excessive alcohol consumption reported [14].…”

Section: Discussionmentioning

confidence: 99%

Hypophosphataemia in old patients is associated with the refeeding syndrome and reduced survival

Kagansky¹,

Levy²,

Koren‐Morag

et al. 2005

Journal of Internal Medicine

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Section: Discussionmentioning

confidence: 99%

Hypophosphataemia in old patients is associated with the refeeding syndrome and reduced survival

Kagansky¹,

Levy²,

Koren‐Morag

et al. 2005

Journal of Internal Medicine

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“…It has been documented that magnesium deficiency can lead to a decrease in the phosphate content of skeletal muscles and an increase in their excretion in urine. Thus, phosphorus deficits play a large role in the etiology of alcohol myopathy and acute rhabdomyolysis [57,58].…”

Section: Phosphorus Deficitmentioning

confidence: 99%

Magnesium, Calcium, Potassium, Sodium, Phosphorus, Selenium, Zinc, and Chromium Levels in Alcohol Use Disorder: A Review

Baj

Flieger

Teresiński

et al. 2020

JCM

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Macronutrients and trace elements are important components of living tissues that have different metabolic properties and functions. Trace elements participate in the regulation of immunity through humoral and cellular mechanisms, nerve conduction, muscle spasms, membrane potential regulation as well as mitochondrial activity and enzymatic reactions. Excessive alcohol consumption disrupts the concentrations of crucial trace elements, also increasing the risk of enhanced oxidative stress and alcohol-related liver diseases. In this review, we present the status of selected macroelements and trace elements in the serum and plasma of people chronically consuming alcohol. Such knowledge helps to understand the mechanisms of chronic alcohol-use disorder and to progress and prevent withdrawal effects, also improving treatment strategies.

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“…Why selective decrease in phosphate reabsorption with phosphate binders would cause severe hypophosphataemia but global nutrient deficiency would not is not entirely understood but may have to do with stimulation of insulin secretion in the former but not in the latter, which would cause phosphate entry into cells, as well as the discrete effect of the phosphate binders specifically on intestinal phosphate transport. Severely malnourished individuals may exhibit profound hypophosphataemia with feeding, the so‐called refeeding syndrome (Knochel, ; Skipper, ).…”

Section: Introductionmentioning

confidence: 99%

Regulation of serum phosphate

Lederer

2014

The Journal of Physiology

123

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The regulation of serum phosphate, an acknowledged risk factor for chronic kidney disease and cardiovascular mortality, is poorly understood. The discovery of fibroblast growth factor 23 (FGF23) as a key regulator of renal phosphate handling and activation of vitamin D has revolutionized our comprehension of phosphate homeostasis. Through as yet undetermined mechanisms, circulating and dietary phosphate appear to have a direct effect on FGF23 release by bone cells that, in turn, causes renal phosphate excretion and decreases intestinal phosphate absorption through a decrease in vitamin D production. Thus, the two major phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitamin D at the nexus of phosphate homeostasis. While our understanding of phosphate homeostasis has advanced, the factors determining regulation of serum phosphate level remain enigmatic. Diet, time of day, season, gender, age and genetics have all been identified as significant contributors to serum phosphate level. The effects of these factors on serum phosphate have major implications for what is understood as 'normal' and for studies of phosphate homeostasis and metabolism. Moreover, other hormonal mediators such as dopamine, insulin-like growth factor, and angiotensin II also affect renal handling of phosphate. How the major hormone effects on phosphate handling are regulated and how the effect of these other factors are integrated to yield the measurable serum phosphate are only now beginning to be studied. AbbreviationsEGFR, epidermal growth factor receptor; FGF23, fibroblast growth factor 23; NHERF1, sodium-hydrogen exchanger regulatory factor isoform 1; PTH, parathyroid hormone; SNP, single nucleotide polymorphism; VDR, vitamin D receptor.

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Hypophosphatemia in the Alcoholic

Cited by 44 publications

References 24 publications

Hypophosphataemia in old patients is associated with the refeeding syndrome and reduced survival

Hypophosphataemia in old patients is associated with the refeeding syndrome and reduced survival

Magnesium, Calcium, Potassium, Sodium, Phosphorus, Selenium, Zinc, and Chromium Levels in Alcohol Use Disorder: A Review

Regulation of serum phosphate

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