Hypophosphataemic osteomalacia associated with a malignant tumour of the tibia: report of a case.

Abstract

A case of vitamin D resistant hypophosphataemic osteomalacia with glycosuria and aminoaciduria is reported. The course of the disease was dramatically altered by the removal of a bone sarcoma which probably had been growing slowly since the onset of the patient's symptoms five years previously. The histology and electron microscopy of the tumour are described. Three years after the operation the patient remains free of symptoms.

Successful Treatment of Tumor-Induced Osteomalacia due to an Intracranial Tumor by Fractionated Stereotactic Radiotherapy

“…TIO is typically, but not universally, caused by benign mesenchymal tumors (2)(3)(4)(5)(6). These tumors are usually small and are sometimes difficult to localize (2).…”

Tumour-induced Osteomalacia Secondary to a Sarcoma

“…There have been, however, reported cases of malignant tumours such as adenocarcinoma of the colon, 7 prostate cancer, metastatic tumours, as well as oseteosarcoma. 8 – 12 …”

Oncogenic Osteomalacia

“…been reported, three of which were osteosarcoma. [13][14][15][16][17][18] Tumors responsible for the metabolic abnormalities arise equally in bone and soft tissue and favor the extremities and craniofacial region. The neoplasms may range in size from 1 to 7 cm at the time of diagnosis.…”