Hypopharyngeal squamous cell carcinoma metastatic to skin

Schultz, Barry M.; Schwartz, Robert A.

doi:10.1016/s0190-9622(85)80009-8

Cited by 14 publications

(7 citation statements)

References 8 publications

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“…Common sites of cutaneous metastases are the scalp, neck, chest, trunk, forearm, thigh, and penis. 379,380 These metastatic lesions usually present as painless solitary or multiple subcutaneous nodules, although rarely they may also mimic an inflammatory process, 371 a necrotizing vasculitis, 381 or an infective process. 377,378 Histopathologically, cutaneous metastases from NPC show a diffuse pattern of dermal involvement by solid aggregates of neoplastic cells.…”

Section: Cutaneous Metastases From Nasopharynx and Hypopharynx Cancersmentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

218

104

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Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

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Section: Cutaneous Metastases From Nasopharynx and Hypopharynx Cancersmentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

218

104

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“…A comprehensive review of the literature revealed one reported case of a lesion from the hypopharynx with metastases to the skin. 3 However, a careful review of this report revealed that the primary had actually arisen from the epiglottis and not from the hypopharynx. Kmucha et al 5 described two cases with dermal metastases, the posterior pharyngeal wall being the site of the primary in one case and the piriform fossa in the other.…”

Section: Discussionmentioning

confidence: 76%

“…11 Immunohistochemical stains for cytokeratins can be used to determine the origin of poorly differentiated carcinomas. 3 Skin metastases from malignancies of the upper aerodigestive tract usually present within months of the initial diagnosis. In a large cohort of 2491 patients it was noted that the median time to occurrence was 6 months, and that skin metastases usually preceded distant metastases (occurrence of which had a median interval of 15.3 months from diagnosis).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous metastases from a hypopharyngeal malignancy

et al. 2005

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We present an unusual case of carcinoma of the piriform fossa, presenting with cutaneous metastases. These metastases are very rare, present in the late stages of disease, and are usually associated with distant metastases and poor prognosis. They often suggest aggressive disease. We believe that cutaneous metastases from a malignancy in the piriform fossa are more unusual than those from other sites of the head and neck.

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“…There are very few reports in the literature about skin metastasis from HNSCC. Schultz and Schwartz[ 6 ] had reported a rare presentation of cutaneous metastasis from carcinoma of the hypopharynx way back in 1985. Veraldi et al .,[ 7 ] noted rarity of skin metastasis from laryngeal cancers and showed only 12 reported cases in literature.…”

Section: Discussionmentioning

confidence: 99%