Hypoparathyroidism and coeliac disease: a potentially dangerous                combination

Köhler, Stefanie; Wass, John

doi:10.1258/jrsm.2009.080401

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…The prevalence of rheumatoid arthritis is not increased in celiac disease [44]. Sjogren's syndrome [45], primary hyperparathyroidism [46], hypoparathyroidism [47], hypopituitarism [48] and systemic lupus erythematosus [49,50] have all been described in association with celiac disease, but usually in a small series or case reports.…”

Section: Other Autoimmune Diseasesmentioning

confidence: 99%

Risk of morbidity in contemporary celiac disease

Lewis

Holmes

2010

Expert Review of Gastroenterology & Hepatology

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Celiac disease is one of the most common chronic diseases encountered in the Western world with a serological prevalence of approximately 1%. Since it is so common, much comorbidity will occur either as associations or simply by chance, or as complications of the disorder. Many of the published studies purporting to establish the frequency of these occurrences have been limited by factors such as the source and number of patients considered, choice of control groups and ascertainment bias. Recent epidemiological studies have attempted to minimize these sources of error and provide more reliable information. Autoimmune diseases constitute clinically important associations, of which Type 1 diabetes mellitus and thyroid disorders are the most important. Several liver disorders, including primary biliary cirrhosis and primary sclerosing cholangitis, are also associated. The frequency of malignant complications of celiac disease is much lower than earlier studies have indicated, with lymphoma increased by approximately fivefold and the absolute number of tumors is small. The increase in fracture risk in celiac disease is only modest. Although neurological and psychiatric conditions affect celiac patients, no disorder specifically associated with celiac disease has been identified. Reproductive problems have been overexaggerated. It is important that these co-morbidities are recognized because if not, symptoms will be falsely attributed to deliberate or inadvertent ingestion of gluten, rather than prompt a search for a second diagnosis. Furthermore, in a patient with an established diagnosis that is considered falsely to account for the whole clinical picture, celiac disease is likely to remain undetected.

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Section: Other Autoimmune Diseasesmentioning

confidence: 99%

Risk of morbidity in contemporary celiac disease

Lewis

Holmes

2010

Expert Review of Gastroenterology & Hepatology

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“…A careful perusal of the previously reported cases (Table ) also showed an improvement in calcium control with a gluten‐free diet in patients with hypoparathyroidism and coeliac disease . In fact, in some cases, hypercalcaemia was noted after the institution of a gluten‐free diet, necessitating a reduction in the daily dose of calcium and vitamin D therapy …”

Section: Discussionmentioning

confidence: 84%

“…11,16,21,23 In fact, in some cases, hypercalcaemia was noted after the institution of a gluten-free diet, necessitating a reduction in the daily dose of calcium and vitamin D therapy. 13,22 The strength of the present study was investigation of a clinically relevant problem related to the prevalence of coeliac disease in a large cohort of patients with IH. In addition, patients with confirmed coeliac disease were followed up for three to 6 months to assess the effect of a gluten-restricted diet on calcaemic control.…”

Section: Discussionmentioning

confidence: 99%

“…9 Information on the association between coeliac disease and IH is scarce and is based on observations in isolated patients. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] In the present study, we systematically assessed a large cohort of patients with IH for the prevalence of coeliac disease-related tissue transglutaminase autoantibodies (anti-tTGAbs) and endomysial autoantibodies (EMAs) and studied the effect of a gluten-free diet in the affected patients on calcaemic control.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of coeliac disease in idiopathic hypoparathyroidism and effect of gluten‐free diet on calcaemic control

Saha

Saini

Makharia

et al. 2015

Clinical Endocrinology

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“…Idiopathic hypoparathyroidism is a rare and possible late complication associated with celiac disease, with only a few cases reported in the literature that could be the result of endomysial antibody molecular cross-reactivity with parathyroid gland cells. 2 It is possible that the length of exposure to these antibodies increases the risk for hypoparathyroidism. 3 Therefore any delay in the diagnosis of celiac disease can be associated with increased mortality, decreased bone mineral density, increased risk of malignancy, recurrent hospitalizations, and impaired quality of life.…”

Section: Diagnosismentioning

confidence: 99%