Hyponatremia in sickle cell disease

Radel, Eva; Kochen, Joseph; Finberg, Laurence

doi:10.1016/s0022-3476(76)81118-3

Cited by 30 publications

(16 citation statements)

References 12 publications

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“…Loss of concentrating capacity may occur quite early in life [2,3] and is transiently reversible in young children by transfusion of normal blood [2,4]. Clinical implications include nocturia, enuresis [5] and a tendency toward dehydration, the latter perhaps predisposing to vaso-occlusive episodes [6]. …”

Section: Introductionmentioning

confidence: 99%

Urine concentrating ability in infants with sickle cell disease: Baseline data from the phase III trial of hydroxyurea (BABY HUG)

Miller

Wang

Iyer

et al. 2009

Pediatric Blood & Cancer

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Background A urine concentrating defect is quite common in sickle cell anemia, has its onset in early childhood, and may be reversible with transfusion. The Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) is a double-blind, placebo-controlled trial to assess efficacy of hydroxyurea in preventing organ damage in young children with sickle cell anemia. Procedures Enrolled infants were subjected to parent-supervised fluid deprivation and urine and serum osmolality were determined. Results Of 185 infants age 7.5 – 17.9 months (mean 13.0+/-2.7) and fluid-deprived 7.4+/-2.4 hours (range 4-13), 178 had concurrent determinations of urine and serum osmolality. Mean serum osmolality was 286+/-6 mOsm/kg H2O (range 275-312) and independent of age, height, weight, or duration of fluid deprivation. Urine osmolality (mean 407+/-151, range 58-794 mOsm/ kg H2O) was greater than serum (p<0.0001) and correlated with duration of fluid deprivation (p=0.001). Of 142 (77.2%) who concentrated urine, 54 (29.4%) had urine osmolality > 500 mOsm/kg H2O. Urine osmolality correlated with 99mTc-DTPA clearance (p=0.02) and serum urea nitrogen (p<0.0001), but not with serum osmolality, gender, age, height, weight or serum creatinine. Infants able to produce urine with osmolality > 500 mOsm/kg H2O had higher mean fetal hemoglobin concentrations than did those who could not (p=0.014). Conclusions Even with often limited fluid deprivation, 77.2 percent of young infants with sickle cell anemia were able to concentrate urine. Preservation of concentrating ability was associated with higher fetal hemoglobin concentration. Assessment will be repeated after two years of hydroxyurea or placebo treatment. (ClinicalTrials.gov number, NCT00006400.)

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Section: Introductionmentioning

confidence: 99%

Urine concentrating ability in infants with sickle cell disease: Baseline data from the phase III trial of hydroxyurea (BABY HUG)

Miller

Wang

Iyer

et al. 2009

Pediatric Blood & Cancer

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“…Loss of concentrating capacity may occur quite early in life 2, 3 and is transiently reversible in young children by transfusion of normal blood 2, 4. Clinical implications include nocturia, enuresis 5, and a tendency toward dehydration, perhaps predisposing to vaso‐occlusive episodes 6.…”

Section: Introductionmentioning

confidence: 99%

Relief of severe immediate postoperative superior vena cava stenosis with covered stent: Case report with midterm follow up

F¹,

Mânica²

2009

Cathet Cardio Intervent

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Sinus venous atrial septal defects are commonly associated with abnormal pulmonary venous connection. Numerous surgical techniques have been proposed with excellent short- and long-term outcomes. Pulmonary and superior vena cava obstructions, as well as rhythm disturbances, are the most common problems seen during follow up. However, acute postoperative superior vena cava obstruction with successful percutaneous covered-stent implantation has not been reported in the literature. The objective of this study is to report a unique case of acute obstruction of the superior vena cava on the first postoperative day after sinus venous atrial septal defect repair in an infant who was successfully relieved by a percutaneous angioplasty with covered-stent implantation, and the midterm follow up after this intervention.

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“…The relationship between SCS and BP first drew attention, and the BP in SCS was first found to be lower by Johnson and Giorgio [1] in 1981, and then several studies were performed following each other in this area [1][2][3][4][5][6][7][8][9][10][11]. Authors have tried to explain this difference by the defect in renal tubular sodium and water retention [1,6], decreased total peripheral resistance [4,7], overproduction of renal prostaglandins [3], and lower weights in these patients per se [5].In our study, we tried to establish BP differences, the probable different incidence of hypertension, and the differences in renal, cardiac, and autonomic nervous system functions between control subjects (CS) and patients with SCS. Furthermore we aimed at pointing out the differences in different age groups (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54), and 55 years and over) and divided some subjects into subtypes of SCS (sickle cell anemia, sickle cell trait, and sickle cell thalassemia).…”

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confidence: 99%

Low Blood Pressure, Decreased Incidence of Hypertension, and Renal Cardiac, and Autonomic Nervous System Functions in Patients with Sickle Cell Syndromes

Karayaylalı

Önal

Yildizer

et al. 2002

Nephron

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Hyponatremia in sickle cell disease

Cited by 30 publications

References 12 publications

Urine concentrating ability in infants with sickle cell disease: Baseline data from the phase III trial of hydroxyurea (BABY HUG)

Urine concentrating ability in infants with sickle cell disease: Baseline data from the phase III trial of hydroxyurea (BABY HUG)

Relief of severe immediate postoperative superior vena cava stenosis with covered stent: Case report with midterm follow up

Low Blood Pressure, Decreased Incidence of Hypertension, and Renal Cardiac, and Autonomic Nervous System Functions in Patients with Sickle Cell Syndromes

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