Hyponatremia in hospitalised patients with heart failure in internal medicine: Analysis of the Spanish national minimum basic data set (MBDS) (2005–2011)

Méndez‐Bailón, Manuel; Barba, Raquel; Miguel‐Yanes, José M. de; Zapatero-Gaviria, Antonio; Calvo-Porqueras, Beatriz; Osuna, Mariam Farid-Zahran; Nuñez-Fernández, Carla; Muñoz‐Rivas, Nuria; Canteli, S. Plaza; Marco-Martínez, Javier

doi:10.1016/j.ejim.2015.06.009

Cited by 4 publications

(2 citation statements)

References 32 publications

(23 reference statements)

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“…Hyponatremia has been reported as a predictor of adverse outcomes in patients with ischemic stroke, myocardial infarction, heart failure, and cirrhosis [8][9][10][11][12][13]. Activation of the renin-angiotensin-aldosterone system, excessive antidiuretic hormone secretion, higher norepinephrine levels, and decreased renal flow in these patients are the main causes of hyponatremia [14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Association between hyponatremia, inflammation, and mortality in patients undergoing peritoneal dialysis: A nationwide observations

Erdogan,

Ata,

Caglayan

et al. 2023

Ther Apher Dial

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IntroductionHyponatremia is the most common electrolyte disorder often present in peritoneal dialysis (PD) patients. The aim of this retrospective study was to investigate the effect of hyponatremia on mortality in patients undergoing PD.MethodsThe health records of adult individuals with an inserted PD catheter identified via the centralized national e‐health database were used.ResultsThe mean age of the 846 patients included in the study was 52.48 years (±14.6). The mean sodium level was 136.51 mEq/L. Sodium levels <137 mEq/L were associated with higher death risk independent of comorbidities. There was a 0.821 times less reduction in mortality for each mEq /L increase in serum sodium.ConclusionOur study provides evidence that monitoring and adjusting serum sodium levels is crucial in managing PD patients with hyponatremia, as low serum sodium level was found to be a significant and independent predictor of mortality.

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Section: Discussionmentioning

confidence: 99%

Association between hyponatremia, inflammation, and mortality in patients undergoing peritoneal dialysis: A nationwide observations

Erdogan,

Ata,

Caglayan

et al. 2023

Ther Apher Dial

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“…[11–13] In addition, there are very few studies in all-Hispanic populations. [14, 15] However, there are no multi-racial cohort studies on this topic that have consisted of a large percentage of Hispanic patients.…”

Section: Introductionmentioning

confidence: 99%

Racial differences and mortality risk in patients with heart failure and hyponatremia

et al. 2019

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Background Hyponatremia is a well-established poor prognostic marker in patients with heart failure. Whether the mortality risk is comparable among different races of patients with heart failure and hyponatremia is unknown. Materials and methods Consecutive patients admitted with acute decompensated heart failure and an admission sodium level<135 mEq/L from 1/1/2001 through 12/31/10 were identified. Patients were divided into four groups based on self-reported race: white, African American, Hispanic and other. African Americans were used as the reference group for statistical analysis. The primary outcome was all-cause mortality. Results We included 4,343 patients, from which 1,356 (31%) identified as white, 1,248 (29%) as African American, 780 (18%) as Hispanic and 959 (22%) as other. During a median follow-up of 23 months, a total of 2,384 patients died: 678 were African American, 820 were white, 298 were Hispanic and 588 were other. After adjusting for baseline demographics, comorbidities and medication use, Hispanic patients had a 45% less risk of death as compared to African Americans (HR .55, CI .48-.64, p<0.05). There was no difference in mortality between white and African American patients (HR 1.04, CI .92–1.2, p = 0.79). Conclusion Hispanic patients admitted for heart failure and who were hyponatremic on admission had an independent lower risk of mortality compared to other groups. These findings may be due to the disparate activity of the renin-angiotensin-aldosterone system among various racial groups. This observational study is hypothesis generating and suggests that treatment of patients with heart failure and hyponatremia should perhaps be focused more on renin-angiotensin-aldosterone system reduction in certain racial groups, yet less in others.

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Impact of hyponatremia on mortality and morbidity in patients with COPD exacerbations

Chalela

González-García

Chillarón

et al. 2016

Respiratory Medicine

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Hyponatremia is the most common electrolyte disorder in hospitalized patients, being associated with increased morbidity and mortality in different clinical conditions. However, the prevalence and impact of this electrolytic disorder in patients hospitalized for an exacerbation of COPD still remains unknown. The aim of the present study was to clarify these points. A total of 424 patients hospitalized due to a COPD exacerbation were consecutively included, showing a frequency of hyponatremia of 15.8% (hyposmolar in most cases). Even though patients with and without hyponatremia showed a similar age, comorbidities, lung function impairment, presence of previous exacerbations, hospitalizations, most of the comorbidities and the overall severity index (APACHE II), their clinical outcomes were worse. Indeed, their hospitalization length, mechanical ventilation requirements and deaths (both during admission and within the months following discharge) were higher than those of non-hyponatremic patients. A sodium threshold lower than 129.7 mEq/L exhibited the better discriminatory power for death prediction. We conclude that hyponatremia (especially if severe) is a predictive marker for a bad clinical course in COPD exacerbations and therefore, patients with this electrolyte abnormality should be carefully monitored.

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Hyponatremia in hospitalised patients with heart failure in internal medicine: Analysis of the Spanish national minimum basic data set (MBDS) (2005–2011)

Cited by 4 publications

References 32 publications

Association between hyponatremia, inflammation, and mortality in patients undergoing peritoneal dialysis: A nationwide observations

Association between hyponatremia, inflammation, and mortality in patients undergoing peritoneal dialysis: A nationwide observations

Racial differences and mortality risk in patients with heart failure and hyponatremia

Impact of hyponatremia on mortality and morbidity in patients with COPD exacerbations

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