Hyponatremia in COPD: A Little Known Complication

Guerra, Javier Miguel Martín; Asenjo, Miguel Martín; Muñoz, Luis Ángel Sánchez; Gutiérrez, Carlos

doi:10.1016/j.arbr.2018.05.003

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several lung diseases, including lung infections, asthma, COPD, lung tumors, cystic fibrosis, and acute respiratory failure, have been associated with SIAD and, subsequently, hyponatremia [128]. Furthermore, hypercapnia reduces renal blood flow either by means of direct renal vasoconstriction or indirectly through noradrenaline secretion [129].…”

Section: Comorbidities Of Hf Associated With Hyponatremiamentioning

confidence: 99%

Hyponatremia in Patients with Heart Failure beyond the Neurohormonal Activation Associated with Reduced Cardiac Output: A Holistic Approach

et al. 2022

View full text Add to dashboard Cite

Background: Heart failure (HF)is considered an epidemic disease with considerable morbidity, mortality and immense healthcare costs. Electrolyte abnormalities are often encountered in patients with HF posing a diagnostic and therapeutic challenge for clinicians. Hyponatremia affects up to one third of HF patients and represents an unfavorable prognostic factor. Summary: Low sodium levels in HF are mainly attributed to the neurohormonal activation secondary to decreased effective circulating volume. However, patients with HF often have several co-morbidities which may cause or exacerbate the pre-existing hyponatremia. Factors that provoke HF, such as alcohol overconsumption, may also be involved in hyponatremia development. Furthermore, drugs which are frequently prescribed to HF patients, especially diuretics, are potential culprits of hyponatremia and should always be addressed, since their withdrawal may reverse hyponatremia. Despite the great prevalence and the deleterious effects hyponatremia in these patients, it is often overlooked and consequently undertreated. In this review we present the mechanisms involved in the development of hyponatremia focusing on those besides neurohormonal activation. We also discuss the proper management of this electrolyte disorder which is frequently complex in patients with HF. Key Messages: Hyponatremia in patients with HF is not only the result of neurohormonal activation; several co-morbidities and frequently used drugs should also be addressed. Hence, a holistic approach is required both for the diagnosis and optimal treatment.

show abstract

Section: Comorbidities Of Hf Associated With Hyponatremiamentioning

confidence: 99%