Hyponatremia during hospitalization and in-hospital mortality in patients hospitalized from heart failure

Saepudin, Saepudin; Ball, Patrick; Morrissey, Hana

doi:10.1186/s12872-015-0082-5

Cited by 24 publications

(21 citation statements)

References 40 publications

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“…In our study, the prevalence of hyponatremia in patients admitted for AECOPD is 10.8% higher than that of patients with community-acquired pneumonia as reported by Cuesta et al [1], but lower than that of patients hospitalized for different causes, including AECOPD [2][3][4]23,24]. In addition to the low prevalence of hyponatremia, the absence of moderate and severe cases also seems noteworthy, despite the high percentage of patients with risk factors to develop it (heart failure, chronic kidney disease, cancer, and certain treatments).…”

Section: Discussioncontrasting

confidence: 57%

Impact of Hyponatremia on COPD Exacerbation Prognosis

García-Sanz¹,

Martínez-Gestoso²,

Calvo-Álvarez

et al. 2020

JCM

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The most common electrolyte disorder among hospitalized patients, hyponatremia is a predictor of poor prognosis in various diseases. The aim of this study was to establish the prevalence of hyponatremia in patients admitted for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), as well as its association with poor clinical progress. Prospective observational study carried out from 1 October 2016 to 1 October 2018 in the following hospitals: Salnés in Vilagarcía de Arousa, Arquitecto Marcide in Ferrol, and the University Hospital Complex of Santiago de Compostela, Galicia, Spain, on patients admitted for AECOPD. Patient baseline treatment was identified, including hyponatremia-inducing drugs. Poor progress was defined as follows: prolonged stay, death during hospitalization, or readmission within one month after the index episode discharge. 602 patients were enrolled, 65 cases of hyponatremia (10.8%) were recorded, all of a mild nature (mean 131.6; SD 2.67). Of all the patients, 362 (60%) showed poor progress: 18 (3%) died at admission; 327 (54.3%) had a prolonged stay; and 91 (15.1%) were readmitted within one month after discharge. Patients with hyponatremia had a more frequent history of atrial fibrillation (AF) (p 0.005), pleural effusion (p 0.01), and prolonged stay (p 0.01). The factors independently associated with poor progress were hyponatremia, pneumonia, and not receiving home O2 treatment prior to admission. Hyponatremia is relatively frequent in patients admitted for AECOPD, and it has important prognostic implications, even when mild in nature.

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Section: Discussioncontrasting

confidence: 57%

Impact of Hyponatremia on COPD Exacerbation Prognosis

García-Sanz¹,

Martínez-Gestoso²,

Calvo-Álvarez

et al. 2020

JCM

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“…[39][40][41] A report from the HARVEST registry also revealed that hyponatremia and worsening sodium levels were associated with mortality in patients hospitalized for AHF. 42) In our results, serum sodium is considered to be an independent mortality predictor which was in relation to a 12.0% increase in mortality risk for each 1U decrease (HR 0.880, 95%CI 0.822-0.943).…”

Section: Discussionmentioning

confidence: 99%

Predictors of Long-Term Mortality in Patients With Acute Heart Failure

et al. 2017

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SummaryTo investigate parameters which were related with long-term mortality in patients hospitalized for acute heart failure (AHF).A total of 287 patients with AHF presenting to the First Affiliated Hospital of Nanjing Medical University were enrolled into the registry from April 2012 to January 2015. The primary endpoint was all-cause mortality within 1 year; the association between variables and prognosis was assessed after 1 year.Among the 287 patients, 17 did not continue follow-up and 47 (17.4%) passed away. Baseline NT-proBNP and sST2 concentrations were higher amongst deceased than among survivors (P < 0.001). Serum sodium concentrations of patients who died were lower (P < 0.001). In receiver operator characteristics (ROC) analyses, the area under the curve (AUC) values for NT-proBNP, sST2, and serum sodium to predict 1-year mortality were 0.699 (95%CI 0.639-0.755), 0.692, (95%CI 0.634-0.747), and 0.694 (95%CI 0.634-0.750), respectively. The optimal cut-off points for NT-proBNP, sST2, and serum sodium were 2137.0 ng/L, 35.711 ng/mL, and 136.6 mmol/L, respectively. In Cox regression analysis, ln-transformed NT-proBNP (HR 1.546, P = 0.039), ln-transformed sST2 (HR1.542, P = 0.049), and serum sodium (HR 0.880, P = 0.000) values reliably predicted long-term mortality after multivariable adjustment.In patients with acute heart failure, NT-proBNP, sST2 and serum sodium are potential predictors of 1-year mortality. (Int Heart J 2017; 58: 409-415)

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“…Hyponatremia is the most common disorder of body fluid and electrolyte balance in hospitalized patients [ 1 ]. The presence of hyponatremia is hazardous since it is associated with increased risk of mortality in hospitalized patients [ 2 ], including those with heart [ 3 ] and liver [ 4 ] diseases, stroke [ 5 ], and chronic kidney disease (CKD) [ 6 , 7 ]. According to recent meta-analysis, hyponatremic subjects showed a 2.6 times higher risk of death than non-hyponatremic subjects, even when the decrease in the serum sodium level was moderate [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Pre-Existing Hyponatremia and Subsequent-Developing Acute Kidney Injury on In-Hospital Mortality: A Retrospective Cohort Study

et al. 2016

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Background and ObjectivesBoth hyponatremia and acute kidney injury (AKI) are common and harmful in hospitalized patients. However, their combined effects on patient mortality have been little studied.MethodsWe retrospectively enrolled 19191 adult patients who were admitted for 1 year. Pre-existing hyponatremia was defined as a serum sodium level < 135 mmol/L on the first measurement of their admission. AKI was defined as a rise in serum creatinine by ≥ 26.5 μmol/L or ≥ 1.5 times of the baseline value of creatinine during the hospital stay.ResultsThe prevalence of pre-existing hyponatremia was 8.2%. During a median 6.0 days of hospital stay, the incidence rates of AKI and in-hospital patient mortality were 5.1% and 0.9%, respectively. Pre-existing hyponatremia independently predicted AKI development and in-hospital mortality (adjusted hazard ratio [HR] 1.300, P = 0.004; HR 2.481, P = 0.002, respectively). Pre-existing hyponatremia and subsequent development of AKI increased in-hospital mortality by 85 times, compared to the patients with normonatremia and no AKI. In subgroup analysis, the AKI group showed higher rates of de novo hypernatremia than the non-AKI group during the admission. De novo hypernatremia, which might be associated with over-correction of hyponatremia, increased in-hospital mortality (HR 3.297, P <0.001), and patients with AKI showed significantly higher rates of de novo hypernatremia than patients without AKI (16.2% vs. 1.4%, P < 0.001, respectively).ConclusionPre-existing hyponatremia may be associated with the development of AKI in hospitalized patients, and both hyponatremia and hospital-acquired AKI could have a detrimental effect on short term patient mortality, which might be related to the inappropriate correction of hyponatremia in AKI patients.

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Hyponatremia during hospitalization and in-hospital mortality in patients hospitalized from heart failure

Cited by 24 publications

References 40 publications

Impact of Hyponatremia on COPD Exacerbation Prognosis

Impact of Hyponatremia on COPD Exacerbation Prognosis

Predictors of Long-Term Mortality in Patients With Acute Heart Failure

The Effects of Pre-Existing Hyponatremia and Subsequent-Developing Acute Kidney Injury on In-Hospital Mortality: A Retrospective Cohort Study

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