Hyponatremia and antidiuresis syndrome

Vantyghem, Marie-Christine; Balavoine, Anne-Sophie; Wémeau, Jean-Louis; Douillard, Claire

doi:10.1016/j.ando.2011.10.001

Cited by 32 publications

(25 citation statements)

References 71 publications

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“…Patients with advanced lung cancer frequently develop metastases to bone and brain, which sometimes cause hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). [13][14][15] Hypercalcemia should be anticipated in patients with bone metastases. Patients may experience nausea/vomiting as a consequence of hypercalcemia and so on or other electrolyte For nausea, the following scoring for response was used: 0 = absence of nausea; 1 = presence of nausea within 3 days after start of oral oxycodone but oxycodone was continued; 2 = presence of nausea within 3 days and oxycodone was discontinued due to nausea.…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors for Nausea or Vomiting in Patients with Cancer Who Receive Oral Oxycodone for the First Time: Is Prophylactic Medication for Prevention of Opioid-Induced Nausea or Vomiting Necessary?

Kanbayashi

Hosokawa

2014

Journal of Palliative Medicine

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Section: Discussionmentioning

confidence: 99%

Predictive Factors for Nausea or Vomiting in Patients with Cancer Who Receive Oral Oxycodone for the First Time: Is Prophylactic Medication for Prevention of Opioid-Induced Nausea or Vomiting Necessary?

Kanbayashi

Hosokawa

2014

Journal of Palliative Medicine

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“…The first involves the hypothalamic magnocellular acting through its peripheral cognate V1a receptor [49,50] , a G-protein-coupled receptor signaling via phospholipase C [51][52] , is largely responsible for regulating water homeostasis and blood pressure [49,53] . The second system consists of parvocellular neurons within the PVN; these neurons produce both AVP and CRH peptide hormones [55] .…”

Section: Arginine Vasopressinmentioning

confidence: 99%

Hypothalamic-pituitary-adrenal axis function during perinatal depression

et al. 2015

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Abnormal function of the hypothalamic-pituitary-adrenal (HPA) axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol proinflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 11β-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby.Keywords: brain; depression; neuroendocrine; pregnancy; stress; glucocorticoids Extensive studies have demonstrated that early life stressors produce changes in behavior and enhance the sensitivity of the stress response systems [1][2][3][4] . Although the genetic background has been implicated in the development of mood-related disorders, and genetic research has identified some chromosomal regions and genes that are involved in susceptibility to mood disorders, the etiology of anxiety and depressive disorders is still not clear in humans, particularly in women with major depressive disorder (MDD) [1] .The pathogenesis of perinatal depression is an emerging field. Although considerable progress has been made in this area in the last few years, there still remain unanswered questions and gaps in our knowledge of the underlying pathogenesis, the long-term impact of perinatal depression on the developing fetus, and the best methods for counseling pregnant women concerning the risks of untreated MDD versus the risks of psychopharmacologic treatment during pregnancy and lactation [5] . Meta-analysis studies have reported that the mean prevalence rate of prenatal depression is ~12% (this varies greatly according to location, mode of assessment, and socioeconomic conditions), and show that a large percentage of pregnant women displaying major depression remain depressed in the postpartum period and/or continuously [6,7] . Anxiety, depressive disorder, and stress during pregnancy are risk Phillipe Leff Gelman, et al. HPA axis in perinatal depression 339 factors for negative outcomes in newborns, like preterm birth or low birth weight; also, insecure attachment and impaired child development could be a consequence of mental disorders during pregnancy [6,[8][9][10] . The mechanisms by which maternal depression impacts fetal and neonatal development are currently under investigation; there is some evidence that depressive symptoms impact the infant's hypothalamic-pituitary-adrenal (HPA) axis, enhancing the ...

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“…30 % des sujets âgés comparés à des sujets jeunes ont ainsi une rénine basse. Cet hyporéninisme hypoaldostéronisme peut devenir symptomatique en dehors de tout diabète, insuffisance rénale ou insuffisance glucocorticoïde (hypotension sensible aux minéralocorticoïdes du sujet âgé, s'accompagnant souvent d'une tendance hyponatrémique [35]. Les dysautonomies sympathiques rencontrées chez les diabé-tiques avec une hypotension orthostatique s'accompagnent fréquemment d'un hyporéninisme hypoaldostéronisme, en particulier chez les sujets âgés (de 65 ans en moyenne), ayant une insuffisance rénale modérée (70 % des cas).…”

Section: Hyporéninisme Hypoaldostéronisme Isoléunclassified