Hypomineralisation or hypoplasia?

Patel, Alpa; Aghababaie, Sahar; Parekh, Susan

doi:10.1038/s41415-019-0782-9

Cited by 38 publications

(39 citation statements)

References 7 publications

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“…Gelişimsel Mine Kusurlarında Minimal İnvaziv Tedavi Seçenekleri. Patel et al, 2019;Willmott et al, 2008) 1. Koruyucu ve Önleyici Tedaviler 3-6 ayda bir uygulanan topikal florür preparatları (Nötral Sodyum Florid jel, Florid vernik), florürlü diş macunu (5000 ppm), florürlü gargara (225 ppm), kazein fosfopeptid -amorf kalsiyum fosfat (CCP-ACP) içerikli ajanlar, reçine veya cam iyonomer esaslı fissür örtücülerin uygulanması.…”

Section: Minimal İnvaziv Tedavi Seçenekleriunclassified

“…Defektin tespiti ile birlikte hastalara ılık su ve yumuşak kıllı diş fırçası ile fırçalama, hassasiyet giderici diş macunu kullanımı ve gargaraların kullanımı önerilmesi ile hassasiyet şikayetinin azaltılması, hastanın oral hijyen alışkanlıklarının normalize edilmesi ve periodontal sağlığının yerine getirilmesi çürük insidansının azaltılması açısından önem teşkil etmektedir. Topikal florid uygulamaları, kalsiyum ve fosfat rezervuarı görevi gören CPP -ACP gibi remineralizasyon ajanları, hipomineralize alanların ve başlangıç çürüklerinin remineralizasyonunu sağlayarak ve bakteri adezyonunu önleyerek başlangıç çürüklerinin ve doku kayıplarının ilerlemesinin engellenmesine yardımcı olmaktadır (Seow,2014;Weerheijm, 2004;Patel et al, 2019). Lokalize veya generalize hipoplazi vakalarında, özellikle genç hastalarda, en iyi restorasyon seçeneği direkt kompozitlerdir 8).…”

Section: İndirekt Tedavilerunclassified

“…Sürme sonrası yıkıma uğramamış semptomsuz büyük azı dişlerinde hassasiyetin ve çürüklerin önlenmesi için topikal florür uygulaması, düşük viskositeli cam iyonomer fissür örtücü ve CCP-ACP gibi remineralizasyon uygulamaları önerilmektedir (Aldred et al, 2013). Ön grup dişlerde renkleşmeler mikroabrazyon ve beyazlatma uygulamaları ile giderilebilmekte, opak lezyonlar ise reçine infiltrasyon yöntemiyle onarılabilmektedir (Patel et al, 2019). Orta şiddetli lezyonlar cam iyonomer veya kompozit restorasyonlar ile tedavi edilebilmektedir.…”

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Developmental Defects of Enamel Tissue from Etiology to Minimally Invasive Treatment Procedures

Berkman¹,

Tuncer²,

Karabay³

et al. 2020

JSTR

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The development process of tissue and organs in the living body is managed by genetic components and is affected by systemic diseases or environmental factors such as trauma, chemicals and radiation. Depending on the development phase that these factors occur, conditions such as deviations from normal growth and development, and the disruptions of tissue quantity and quality may occur. Disruption of the normal functioning of the amelogenesis steps for various reasons causes defections of enamel matrix formation, resorption, and subsequent calcification process. Clinically, this situation appears as defects characterized by features ranging from diffuse opacities to the complete absence of tooth enamel. Developmental enamel defects, the prevalence of which varies between 10% and 80%, cause problems that negatively affect individuals' quality of life, such as aesthetic problems, hypersensitivity, rapidly progressing caries, and tooth tissue loss. The aim of this study was to investigate the developmental enamel defects, their relationship with the development stages of the enamel, the etiological factors, in the light of current information. Clinical management of these defects and rehabilitation with minimally invasive approaches were evaluated with exemplary cases.

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Section: Minimal İnvaziv Tedavi Seçenekleriunclassified

Section: İndirekt Tedavilerunclassified

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Developmental Defects of Enamel Tissue from Etiology to Minimally Invasive Treatment Procedures

Berkman¹,

Tuncer²,

Karabay³

et al. 2020

JSTR

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“…7,8 Although the etiology of GEH is not clearly understood, it may occur as a result of systemic, environmental and genetic factors. 1,2,7,14,15 Up to date, specific causes underlying the occurrence of particular types of enamel hypoplasia have not been identified. 3 However, those with unknown etiology that occur independently of heredity and teratogenic factors are called idiopathic GEH (IGEH).…”

Section: Introductionmentioning

confidence: 99%

Ghrelin hormone might have a potential role in amelogenesis

2021

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Aims: Amelogenesis imperfecta and generalised enamel hypoplasia are developmental dental anomalies that affect dental enamel. While amelogenesis imperfecta results from various gene mutations, the exact underlying mechanisms of the etiopathogenesis of both remain unclear. This study aims to evaluate Ghrelin hormone levels in children with generalised enamel hypoplasia to establish whether Ghrelin might have a potential role in enamel hypoplasia's etiology. The second purpose is to determine the correlations among the blood levels of Ghrelin, growth hormone (GH), insulin-like growth factor-1 (IGF-1), bone alkaline phosphatase (BALP) and osteocalcin (OC) that are vital in dental development. Material and methods:Study was designed with two study groups, AI (hypoplastic amelogenesis imperfecta) (n = 15; mean-age 10.36 ± 1.90) and GEH (idiopathic generalised enamel hypoplasia) (n = 15; mean-age 10.42 ± 1.84), and a healthy control (n = 15; mean-age 10.39 ± 1.91) group. After fasting for 10-12 hours, simultaneous blood samples were collected; then, after centrifugation, serum and plasma were stored at −80°C until the day of analysis. Total Ghrelin levels of plasma and serum levels of GH, IGF-1, BALP and OC were measured using commercial ELISA kits.Results: Ghrelin levels of AI and GEH groups were significantly lower (P < .01) than the control group. Conclusion:This is the first study to reveal the decreased levels of Ghrelin in plasma of children with generalised enamel hypoplasia, suggesting a potential role for Ghrelin in amelogenesis. In order to determine its function in enamel formation, further studies should be carried out. The result of the present study suggests that paediatricians refer children with abnormal Ghrelin levels to a paediatric dentist to contribute to appropriate prophylactic and therapeutic interventions. Generalised enamel hypoplasia may also indicate possible abnormalities in Ghrelin levels for paediatricians.How to cite this article: Zorlu S, Aren G, Balci Ekmekci O.Ghrelin hormone might have a potential role in amelogenesis.

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“…Entretanto sabe-se que a AI, é uma doença familiar hereditária rara e complexa, que causa defeitos quantitativos no esmalte (Sales et al, 2016;Kim et al, 2019). Assim como também a hipoplasia que é oriunda de alterações que acometem o esmalte durante o estágio de formação da matriz resultando na redução da espessura ou da quantidade de esmalte (Scheidt et al, 2016;Martinhão et al, 2015;Patel et al, 2019).…”

Section: Introductionunclassified

Prevalência de defeitos de esmalte em crianças atendidas em uma clínica de odontopediatria

Silva

Alencar

Barbosa

et al. 2020

RSD

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The objective of this article was to evaluate the prevalence of enamel development defects (EDD) in children attended in the discipline of Children's Clinic II of the Dentistry course of the Universidade Federal de Campina Grande (UFCG), in Patos, Paraíba, Brazil. This study was cross-sectional, observational and retrospective using clinical records, from which information was learned about the type of EDD, number of teeth affected, clinical complaint and demographic variables. The data obtained were analyzed with of IBM SPSS Statistics software, worked by descriptive statistics and submitted to fisher's Chi-square and Exact statistical test considered significant at the level of 5% (p<0.05). 273 medical records were evaluated, of these 36 reported some enamel defect in patients, with an average of 3.16 teeth affected per child. Defects were present in children aged 3-12 years with a mean of 8.28 years (± 2.35), mostly female (61.1%) and resident of the city of Patos, Paraíba (88.9%). Its main complaints were, mainly, toothache (36.1%) and the search for treatment (25%). Defects found were incisor-molar hypomineralization (IMH), isolated hypomineralizations, hypoplasia and dental fluorosis. The present study points to a prevalence of EDD of 13.1%, and a higher frequency of hypoplasia (55.6%) and dental fluorosis (30.6%).

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Hypomineralisation or hypoplasia?

Cited by 38 publications

References 7 publications

Developmental Defects of Enamel Tissue from Etiology to Minimally Invasive Treatment Procedures

Developmental Defects of Enamel Tissue from Etiology to Minimally Invasive Treatment Procedures

Ghrelin hormone might have a potential role in amelogenesis

Prevalência de defeitos de esmalte em crianças atendidas em uma clínica de odontopediatria

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