Hypomagnetic Field Exposure Affecting Gut Microbiota, Reactive Oxygen Species Levels, and Colonic Cell Proliferation in Mice

Zhan, Aisheng; Luo, Yukai; Qin, Huafeng; Lin, Wei; Tian, Lanxiang

doi:10.1002/bem.22427

Cited by 3 publications

(1 citation statement)

References 71 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in terms of the risks that are posed by radiation on human health, we also have to consider the effects of radiation on the human microbiomes, particularly the gut microbiota. Interestingly, in mice, the gut microbiota is also influenced by hypogravity [ 124 ], therefore, it is likely that there may be interactions between radiation and magnetic fields in alterations to the gut microbiome during space flight.…”

Section: Additional Risks Of Space Flight Into Deep Space and Living ...mentioning

confidence: 99%

Homo sapiens—A Species Not Designed for Space Flight: Health Risks in Low Earth Orbit and Beyond, Including Potential Risks When Traveling beyond the Geomagnetic Field of Earth

Hart

2023

Life

View full text Add to dashboard Cite

Homo sapiens and their predecessors evolved in the context of the boundary conditions of Earth, including a 1 g gravity and a geomagnetic field (GMF). These variables, plus others, led to complex organisms that evolved under a defined set of conditions and define how humans will respond to space flight, a circumstance that could not have been anticipated by evolution. Over the past ~60 years, space flight and living in low Earth orbit (LEO) have revealed that astronauts are impacted to varying degrees by such new environments. In addition, it has been noted that astronauts are quite heterogeneous in their response patterns, indicating that such variation is either silent if one remained on Earth, or the heterogeneity unknowingly contributes to disease development during aging or in response to insults. With the planned mission to deep space, humans will now be exposed to further risks from radiation when traveling beyond the influence of the GMF, as well as other potential risks that are associated with the actual loss of the GMF on the astronauts, their microbiomes, and growing food sources. Experimental studies with model systems have revealed that hypogravity conditions can influence a variety biological and physiological systems, and thus the loss of the GMF may have unanticipated consequences to astronauts’ systems, such as those that are electrical in nature (i.e., the cardiovascular system and central neural systems). As astronauts have been shown to be heterogeneous in their responses to LEO, they may require personalized countermeasures, while others may not be good candidates for deep-space missions if effective countermeasures cannot be developed for long-duration missions. This review will discuss several of the physiological and neural systems that are affected and how the emerging variables may influence astronaut health and functioning.

show abstract

Section: Additional Risks Of Space Flight Into Deep Space and Living ...mentioning

confidence: 99%

Homo sapiens—A Species Not Designed for Space Flight: Health Risks in Low Earth Orbit and Beyond, Including Potential Risks When Traveling beyond the Geomagnetic Field of Earth

Hart

2023

Life

View full text Add to dashboard Cite

show abstract

The Effect of a Magnetic Field on the Generation of Free Radicals in the Interaction of Quaternary Ammonium Compounds with Hydroperoxides

Krugovov,

Gatin,

Potapova

et al. 2024

Russ. J. Phys. Chem. B

View full text Add to dashboard Cite

The Role of Oxidative Stress in Hypomagnetic Field Effects

Tian,

Luo,

Ren

et al. 2024

Antioxidants

View full text Add to dashboard Cite

The geomagnetic field (GMF) is crucial for the survival and evolution of life on Earth. The weakening of the GMF, known as the hypomagnetic field (HMF), significantly affects various aspects of life on Earth. HMF has become a potential health risk for future deep space exploration. Oxidative stress is directly involved in the biological effects of HMF on animals or cells. Oxidative stress occurs when there is an imbalance favoring oxidants over antioxidants, resulting in cellular damage. Oxidative stress is a double-edged sword, depending on the degree of deviation from homeostasis. In this review, we summarize the important experimental findings from animal and cell studies on HMF exposure affecting intracellular reactive oxygen species (ROS), as well as the accompanying many physiological abnormalities, such as cognitive dysfunction, the imbalance of gut microbiota homeostasis, mood disorders, and osteoporosis. We discuss new insights into the molecular mechanisms underlying these HMF effects in the context of the signaling pathways related to ROS. Among them, mitochondria are considered to be the main organelles that respond to HMF-induced stress by regulating metabolism and ROS production in cells. In order to unravel the molecular mechanisms of HMF action, future studies need to consider the upstream and downstream pathways associated with ROS.

show abstract

Hypomagnetic Field Exposure Affecting Gut Microbiota, Reactive Oxygen Species Levels, and Colonic Cell Proliferation in Mice

Cited by 3 publications

References 71 publications

Homo sapiens—A Species Not Designed for Space Flight: Health Risks in Low Earth Orbit and Beyond, Including Potential Risks When Traveling beyond the Geomagnetic Field of Earth

Homo sapiens—A Species Not Designed for Space Flight: Health Risks in Low Earth Orbit and Beyond, Including Potential Risks When Traveling beyond the Geomagnetic Field of Earth

The Effect of a Magnetic Field on the Generation of Free Radicals in the Interaction of Quaternary Ammonium Compounds with Hydroperoxides

The Role of Oxidative Stress in Hypomagnetic Field Effects

Contact Info

Product

Resources

About