Hypomagnesemic Seizures: Case Report and Presumed Pathophysiology

Abstract

Hypomagnesemia has previously been recognized as an uncommon cause of seizures. The electrolyte abnormality is caused by poor gastrointestinal absorption or excessive renal wasting, both from a variety of causes. We report on a 5-week-old patient who developed hypomagnesemic seizures as a consequence of renal magnesium wasting. Although the exact pathophysiology of hypomagnesemic seizures remains uncertain, currently available information suggests that it is related to disinhibition of the N-methyl-D-aspartate-type glutamate receptor-sodium channel complex.

Gitelman Syndrome in a School Boy Who Presented with Generalized Convulsion and Had a R642H/R642W Mutation in theSLC12A3Gene

“…For this reason, he was tentatively diagnosed with epilepsy. While seizures are not common in GS, convulsions due to severe metabolic alkalosis or hypomagnesemia can occur [4, 10], and in such cases, the serum Mg levels are extremely reduced (<1.0 mg/dL) [11, 12]. However, the serum Mg levels of our case were in the range of 1.4–1.8 mg/dL; thus it remains unclear whether hypomagnesemia played a role for the development of the seizure in this patient.…”

Myoclonus and Metabolic Alkalosis from Licorice in Antacid

“…Therefore, it is also possible that hypomagnesemia induced myoclonus. Although the pathophysiology of hypomagnesemic seizures remains unclear, hypomagnesemia has been reported as an uncommon cause of seizures especially in infants and neonates (12). In this case the laboratory data on admission showed increased leukocyte counts and elevated serum CPK and CRP levels.…”

Epilepsy in women with gynecologic malignancies

“…Seizures often appear when serum levels of Mg 2+ are below 1.0 mg/dl. However, there are also reports of seizures occurring when serum levels of Mg 2+ are as high as 1.4 mg/dl [85]. For personal use only.…”

“…Nishida et al [94] conducted a clinical series, where 14 patients with gynecological adenocarcinoma were treated with ifosfamide, adriamycin and cisplatin combined chemotherapy. Of these patients, 85.7% showed grade 4 leucopenia and maximal anti-infection treatment was required. This indicates that cancer patients are at a high risk of CNS infections.…”