Hypolipidemic effects of acute and sub-chronic administration of an aqueous extract of Ajuga iva L. whole plant in normal and diabetic rats

El-Hilaly, Jaouad; Tahraoui, Adel; Israili, Zafar H.; Lyoussi, Badiaâ

doi:10.1016/j.jep.2005.11.023

Cited by 52 publications

(34 citation statements)

References 40 publications

(54 reference statements)

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“…The observed activities could be due to one or more of the compounds found in Ajuga iva L. such as 8-O-acetyl harpagide, ajugarine, apigenin-7-O neohesperidoside, barpagide, caffeine, clorogenes, cyasterone, diglycerides, 14,15-dihydroajugapitin, ecdysones, ecdysterones, flavonoids, iridoides, makisterone A, naringin, neohesperidoside, phenylcarboxylic acids, tannin polyphenols [66]; [67] . It was reported that the Ajuga iva extract decreases plasma cholesterol and triglycerides rats [24] . In addition, no apparent toxicity was observed for this plant [21] .…”

Section: Ferrous Ion Chelating Activitymentioning

confidence: 96%

“…It has been used to treat dysuria and painful joints of the limbs [23] . Ajuga iva extract decreases plasma cholesterol and triglycerides when given as a single or repeated oral doses in normal and STZ-diabetic rats [24] . The current study was undertaken to investigate the inhibitory action on xanthine oxidase and the in vitro antioxidant and radical scavenging effects of the Ajuga iva extracts.…”

Section: Extraction Of Phenolic Compoundsmentioning

confidence: 98%

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Antioxidants, Free Radicals Scavenging and Xanthine Oxidase Inhibitory Potentials of Ajuga iva L. Extracts.

Baghiani

Boumerfeg²,

Adjadj

et al. 2011

Free Radicals and Antioxidants

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Section: Ferrous Ion Chelating Activitymentioning

confidence: 96%

Section: Extraction Of Phenolic Compoundsmentioning

confidence: 98%

Antioxidants, Free Radicals Scavenging and Xanthine Oxidase Inhibitory Potentials of Ajuga iva L. Extracts.

Baghiani

Boumerfeg²,

Adjadj

et al. 2011

Free Radicals and Antioxidants

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“…Insulin therapy is used for management of diabetes mellitus but there are several drawbacks, which include insulin allergy, insulin antibodies, lipodystrophy, autoimmunity and other delayed complications like morphological changes in kidney and severe vascular complications [13][14][15]. Thus, new, relatively non-toxic, therapeutic agents are needed to treat hyperglycemia, which also would correct dyslipidemia to reduce the risk of cardiovascular complications of diabetes [16].…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

Al-Logmani¹,

Zari²

2011

JDM

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The long-term effects of Nigella sativa L. oil on some physiological parameters were investigated in normal and streptozotocin (STZ)-induced diabetic male Wistar rats. STZ-induced diabetic rats showed significant increases in the levels of blood glucose, triglycerides, cholesterol, low density lipoprotein (LDL-cholesterol), uric acid, urea, creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) while high density lipoprotein (HDL-cholesterol) and total protein levels were significantly decreased compared to normal rats. Administration of black seed oil to diabetic rats resulted in a significant decrease in blood glucose, triglycerides, cholesterol, LDL-cholesterol ALT, AST and uric acid while HDL-cholesterol level was markedly increased compared to untreated diabetic rats after seven weeks of treatment. The results of this study indicate that the diet containing the oil of N. sativa improves the examined physiological parameters in STZ-induced diabetic rats especially when it is used for a longer period.

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“…Some Ajuga species, such as A. remota, is traditionally utilized as an herbal remedy for the treatment of fever, infections, malaria as well as tuberculosis (Israili and Lyoussi 2009;Cocquyt et al 2011). Hypoglycaemic, anti-arthritic, antioxidant, antimicrobial, anti-fungal and anti-inflammatory effects of Ajuga species have also been reported in previous studies (Kariba 2001;El-Hilaly and Lyoussi 2002;El-Hilaly et al 2006;Kaithwas et al 2012;Singh et al 2012;Ben Mansour et al 2013;Hsieh et al 2014). The genus Ajuga is represented by 11 species in the flora of Turkey (Davis 1982).…”

Section: Introductionmentioning

confidence: 85%

Evaluation of in vitro antiprotozoal activity of Ajuga laxmannii and its secondary metabolites

Atay

Kırmızıbekmez

Kaiser

et al. 2016

Pharmaceutical Biology

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Context Some Ajuga L. (Lamiaceae) species are traditionally used for the treatment of malaria, as well as fever, which is a common symptom of many parasitic diseases. Objective In the continuation of our studies on the identification of antiprotozoal secondary metabolites of Turkish Lamiaceae species, we have investigated the aerial parts of Ajuga laxmannii. Materials and methods The aerial parts of A. laxmannii were extracted with MeOH. The H 2 O subextract was subjected to polyamide, C 18 -MPLC and SiO 2 CCs to yield eight metabolites. The structures of the isolates were elucidated by NMR spectroscopy and MS analyses. The extract, subextracts as well as the isolates were tested for their in vitro antiprotozoal activities against Plasmodium falciparum, Trypanasoma brucei rhodesiense, T. cruzi and Leishmania donovani at concentrations of 90-0.123 mg/mL. Results Two iridoid glycosides harpagide (1) and 8-O-acetylharpagide (2), three o-coumaric acid derivatives cis-melilotoside (3), trans-melilotoside (4) and dihydromelilotoside (5), two phenylethanoid glycosides verbascoside (6) and galactosylmartynoside (7) and a flavone-C-glycoside, isoorientin (8) were isolated. Many compounds showed moderate to good antiparasitic activity, with isoorientin (8) displaying the most significant antimalarial potential (an IC 50 value of 9.7 mg/mL). Discussion and conclusion This is the first report on the antiprotozoal evaluation of A. laxmannii extracts and isolates. Furthermore, isoorientin and dihydromelilotoside are being reported for the first time from the genus Ajuga.ARTICLE HISTORY

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Hypolipidemic effects of acute and sub-chronic administration of an aqueous extract of Ajuga iva L. whole plant in normal and diabetic rats

Cited by 52 publications

References 40 publications

Antioxidants, Free Radicals Scavenging and Xanthine Oxidase Inhibitory Potentials of Ajuga iva L. Extracts.

Antioxidants, Free Radicals Scavenging and Xanthine Oxidase Inhibitory Potentials of Ajuga iva L. Extracts.

Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

Evaluation of in vitro antiprotozoal activity of Ajuga laxmannii and its secondary metabolites

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