Hypolipidemic Drugs Can Change the Composition of Rat Brain Lipids

Vecka, Marek; Tvrzická, E; Staňková, Barbora; Novák, František; Nováková, Olga; Žák, Aleš

doi:10.1620/tjem.204.299

Cited by 15 publications

(16 citation statements)

References 47 publications

(44 reference statements)

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“…Effects of fluvastatin in the rat brain were shown by Vecka et al (2004). Another study reported that lovastatin and simvastatin strongly reduced the levels of free cholesterol in synaptozomal plazma membranes and lovastatin and pravastatin significantly reduced cholesterol levels in the exofacial membrane leaflet.…”

Section: Discussionmentioning

confidence: 97%

“…The effects of several statins on lipid composition of the brain in rats, including fluvastatin, were observed by Vecka et al (2004), in which fluvastatin, an important member of the statin family, was shown to increase sphingomyelin and to decrease diphosphatidylglycerol contents in rat brains. Yet, the most important changes in the fatty acid profile being in the ceramide monohexosides, lead to a decrease in the content of saturated fatty acids and an increase in the content of polyunsaturated fatty acids.…”

mentioning

confidence: 99%

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Fluvastatin Alters Psychomotor Performance and Daily Activity but not the Spatial Memory in Rats

Baytan

Alkanat

Özeren

et al. 2006

Tohoku J. Exp. Med.

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BAYTAN, S.H., ALKANAT, M., OZEREN, M., EKINCI, M. and AKGUN, A. Fluvastatin Alters Psychomotor Performance and Daily Activity but not the Spatial Memory in Rats.Tohoku J. Exp. Med., 2006, 209 (4), 311-320 Statins, inhibitors of cholesterol synthesis for treating dyslipidemia and preventing cardiovascular complications, have been shown to alter central nervous system functions. Our aim was to investigate the effects of the fluvastatin, a member of statin family, on psychomotor performance, daily activity and spatial memory. Sprague-Dawley rats were treated with fluvastatin (n = 8) or placebo as a control (n = 11) regardless of sex. Fluvastatin (7.5 mg/kg) was administered orally once a day for four weeks, while the control group was administered only placebo. Psychomotor performance was measured by rotarod tests. No significant difference was observed in the fluvastatin group over the course of weeks, but the control group preferred to stay on the device shorter times ( p < 0.05). For the first three weeks of the drug administration there was a statistical difference between the groups, however no difference was found after the 4th week. There was no difference in the Barnes maze spatial memory test between the groups and also within the groups over the course of time. Daily activity tests revealed that stereotypical and vertical movements of the fluvastatin group were significantly less than the control group in all four weeks. Ambulatory movements and the distances taken by the fluvastatin group were decreased significantly over the course of time ( p < 0.005 and p < 0.001, respectively), but the control group did not reveal any significant change. Our results suggest that fluvastatin altered psychomotor performance and daily activity in rats, but it did not affect the spatial memory. These behavioral changes might be associated with alterations in the composition of the brain lipids caused by fluvastatin. statin; fluvastatin; behavior; Barnes maze; psychomotor

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Fluvastatin Alters Psychomotor Performance and Daily Activity but not the Spatial Memory in Rats

Baytan

Alkanat

Özeren

et al. 2006

Tohoku J. Exp. Med.

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show abstract

“…Cholesterol is a principal component of myelin, a fatty sheath that serves an essential role in cellular signaling and blood-brain barrier integrity [7]. Statins, regardless of their lipophilicity and ability to penetrate the blood-brain barrier, alter the composition of brain lipids in rat models [8]. Additionally, reduced serum cholesterol may also enhance blood-barrier permeability, exposing the CNS to normally barred toxins [9].…”

Section: Why It Is Biologically Plausible Thatmentioning

confidence: 99%

PCSK9 Inhibitors and Neurocognitive Adverse Events: Exploring the FDA Directive and a Proposal for N-of-1 Trials

Swiger¹,

Martin²

2015

Drug Saf

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“…Glial cells use HMG-CoAR as the rate limiting enzyme in the synthesis of cholesterol (Snipes and Suter 1997). Vecka et al (2004) reported that fenofibrate, fluvastatin, lovastatin and pravastatin alter the brain lipid composition in rats. Simvastatin has also been shown to reduce brain cholesterol synthesis in guinea pigs (Lutjohann et al 2004).…”

Section: Daily Activity Testmentioning

confidence: 99%

Simvastatin Impairs Spatial Memory in Rats at a Specific Dose Level

Baytan

Alkanat

Okuyan

et al. 2008

Tohoku J. Exp. Med.

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Statins, inhibitors of cholesterol synthesis, are used to prevent cardiovascular complications. Moreover, statins have been shown to influence some cognitive functions. The modulating effects of simvastatin, one member of the statin family, on memory-related neurotransmitters and neuronal structures have also been reported. We aimed to investigate the behavioral effects of long-term simvastatin application on daily activity, psychomotor performance and spatial memory using Sprague-Dawley rats. Simvastatin (10 or 30 mg/kg/day) was administered orally to rats, in parallel with a vehicle-treated group. Daily activity test results of both simvastatin groups were found similar to the vehicle group after five weeks of simvastatin or vehicle application. Psychomotor performance was measured with the rotarod test. After 6 weeks of simvastatin or vehicle application, the vehicle-treated group stayed on the rotarod device for a shorter time compared with both simvastatintreated groups. Spatial memory was evaluated by the Barnes maze test. Four weeks of 10 mg/kg/day simvastatin application led to poorer scores on spatial memory compared to the vehicle group, but surprisingly, this effect was not seen in the 30 mg/kg/day group. Our results revealed that simvastatin administration had no significant effect on daily activity. Psychomotor performance test results suggested that simvastatin alters psychomotor behavior at higher nervous system levels. Spatial memory test results indicate that longterm simvastatin usage impairs spatial memory only at 10 mg/kg/day dose. Barnes maze; behavior; statins; brain; locomotor.Tohoku

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Hypolipidemic Drugs Can Change the Composition of Rat Brain Lipids

Cited by 15 publications

References 47 publications

Fluvastatin Alters Psychomotor Performance and Daily Activity but not the Spatial Memory in Rats

Fluvastatin Alters Psychomotor Performance and Daily Activity but not the Spatial Memory in Rats

PCSK9 Inhibitors and Neurocognitive Adverse Events: Exploring the FDA Directive and a Proposal for N-of-1 Trials

Simvastatin Impairs Spatial Memory in Rats at a Specific Dose Level

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