Hypolipidemic and hypocholesterolemic effect of argan oil (Argania spinosa L.) in Meriones shawi rats

Berrougui, Hicham; Ettaib, Abdelkader; González, Macarena Donoso; Sotomayor, Marı́a Álvarez de; Bennani-Kabchi, N.; Hmamouchi, M.

doi:10.1016/s0378-8741(03)00176-4

Cited by 89 publications

(62 citation statements)

References 10 publications

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“…These results are consistent with the study conducted by Derouiche et al [26], who reported that in adult men within a controlled environment, the daily consumption of argane oil has no effect on the anthropometric status [26,27]. Experiments in vivo on animal models showed that nutritional intervention based on dietary argane oil led to a significant decrease of body weight after six weeks, which was accompanied by reduction of blood lipoproteins, total cholesterol, low density lipoprotein (LDL)-cholesterol and triglycerides [28]. The beneficial effect of argane oil on human health was also reported by Ould-Mohamedou et al [29], showing a great impact on lipid profile and LDL susceptibility to lipid peroxidation in both healthy subjects and dyslipidemic patients.…”

Section: Discussionsupporting

confidence: 88%

Impact of Consumption of Olive and Argane Oils on Anthropometric Profile of Postmenopausal Women in Morocco

Labraimi¹,

Mzibri²,

Derouiche³

et al. 2015

JAST-B

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Abstract:Worldwide, large studies have shown that the menopause is mainly associated with substantial changes in body composition that result in an increase in waist circumference, fat accumulation and specially weight gain. This overweight could be exacerbated by fat intake. Thus, this study was planned to evaluate the impact of the consumption of olive and argane oils on anthropometric profile and body composition of postmenopausal women. The nutritional intervention was conducted over a period of eight weeks, involving daily consumption of 25 mL of argane oil or olive oil in 151 postmenopausal women (55.49 ± 6.18 years old). The anthropometric profile (weight, height and body mass index (BMI)) and body composition (fat mass (FM) and lean mass (LM)) were determined at 0 week (baseline), and after the 4th and 8th weeks of nutritional intervention. Results clearly demonstrated that argane oil or olive oil consumption did not affect the anthropometric parameters and the body composition of postmenopausal women. Thus, argane and/or olive oils' regular diet does not lead to weight gain, and postmenopausal women could benefit from their impact on health for a better quality of life and to overcome all menopause associated problems. A longer period of nutritional intervention is required to confirm the trend down that was recorded.

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Section: Discussionsupporting

confidence: 88%

Impact of Consumption of Olive and Argane Oils on Anthropometric Profile of Postmenopausal Women in Morocco

Labraimi¹,

Mzibri²,

Derouiche³

et al. 2015

JAST-B

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“…The effect of OM on high fat diet-induced hypercholesterolemia was studied using the method described by Berroughui et al 13 with slight modifications introduced after pilot studies. Adult SD rats (12-14 weeks old, weighing 140-160 g) were randomly divided into three groups (7-10 in each).…”

Section: Pharmacological Parametersmentioning

confidence: 99%

Antihypertensive, antidyslipidemic and endothelial modulating activities of Orchis mascula

et al. 2009

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The objective of this study was to investigate the possible mode(s) of action for the medicinal use of Orchis mascula (OM) (family Orchidaceae) in hypertension and dyslipidemia. In spontaneously hypertensive rats (SHRs), OM significantly (Po0.05) reduced systolic blood pressure to 174.2±9.63 vs. 203.4±7.13 mm Hg (mean±s.e.m.; n¼7-10) and improved endothelial dysfunction by increasing acetylcholine-induced relaxation. In normotensive anesthetized rats, the crude extract of OM (Om.Cr) at 10 and 30 mg kg À1 caused a dose-dependent attenuation of mean arterial pressure. OM also decreased serum triglycerides to 29.28 ± 6.99 vs. 93.84 ± 5.7 mg per 100 ml (Po0.001), low-density lipoprotein-cholesterol to 5.99 ± 1.27 vs. 21.9 ± 3.5 mg per 100 ml (Po0.05) and atherogenic index to 0.096±0.017 vs. 0.36±0.08 mg per 100 ml (Po0.05). OM significantly reduced lipid levels in tyloxapol and high fat diet-induced hyperlipidemia. In a second model, OM also reduced gain in body weight with a reduction in daily diet consumption. In isolated rabbit aorta, Om.Cr caused concentration-dependent relaxation of both phenylephrine and high K + (80 mM)-induced contractions and a rightward shift of the calcium concentration-response curves similar to the effect seen with verapamil. In conclusion, OM shows antihypertensive and endothelial-modulating effects mediated through multiple pathways that include direct vasodilation by calcium channel blockade and reduction of plasma lipids by inhibition of biosynthesis, absorption and secretion. This study rationalizes the medicinal use of OM in hypertension and dyslipidemia. However, further studies are required to identify the active constituents of this plant.

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“…Le choix de cette dose est basé sur l'étude expérimentale de Berrada et al [6]. Berrougui et al [7][8][9][10][11][12][13][14][15] ont travaillé avec une dose deux fois plus grande. Toutefois, avec la dose de 5 mL/kg/j, nous assurons une augmentation moyenne estimée à 50 % des lipides ingérés chez le groupe traité en comparaison avec le groupe non traité.…”

Section: Discussionunclassified

Effet de l’huile d’argan sur la contractilité de l’aorte : susceptibilité au stress oxydatif

Benajiba

Leiris

Lyan

et al. 2006

OCL

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Hypolipidemic and hypocholesterolemic effect of argan oil (Argania spinosa L.) in Meriones shawi rats

Cited by 89 publications

References 10 publications

Impact of Consumption of Olive and Argane Oils on Anthropometric Profile of Postmenopausal Women in Morocco

Impact of Consumption of Olive and Argane Oils on Anthropometric Profile of Postmenopausal Women in Morocco

Antihypertensive, antidyslipidemic and endothelial modulating activities of Orchis mascula

Effet de l’huile d’argan sur la contractilité de l’aorte : susceptibilité au stress oxydatif

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