Hypolipidemic and antioxidant effects of buckwheat leaf and flower mixture in hyperlipidemic rats

Brenesel, Maja Đurendić; Popović, Tamara; Pilija, Vladimir; Arsić, Aleksandra; Milic, Miljan; Kojić, Danijela; Jojić, Nikola; Milić, Nataša

doi:10.17305/bjbms.2013.2389

Cited by 24 publications

(22 citation statements)

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“…In our previous supplementation trials on BLF by decreasing the percentage of palmitic acid and total SFA and increasing stearic acid and total PUFA improved FAs profi les in rat plasma, demonstrating an overall hypolipidemic effect in hyperlipidemic rats [10].…”

Section: Discussionmentioning

confidence: 77%

“…These effects were accompanied with improvement of FAs profi les of plasma phospholipids where supplementation with BLF signifi cantly decreased the percentage of palmitic acid and total saturated fatty acids (SFA) and increased the percentage of stearic acid and total PUFA [10]. To our knowledge, no reports are available assessing buckwheat effects on fatty acids in the brain.…”

Section: Introductionmentioning

confidence: 99%

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Effects Of Dietary Supplementation With A Mixture Of Buckwheat Leaf And Flower On Fatty Acid Composition Of Rat Brain Phospholipids

et al. 2015

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The aim of our study was to stablish the possible alternations in fatty acid composition of brain phospholipids in rats on a standard and high-fat diet supplemented with buckwheat leaf and fl ower mixture (BLF) and subsequent possible benefi cial effects of BLF. Four months old male Wistar rats were randomly divided into fi ve experimental groups fed a standard diet, standard diet supplemented with 5% BLF, high-fat diet, high-fat diet with full-period (13 weeks) of 5% BLF supplementation and high-fat diet with partial-period (7 weeks) of 5% BLF supplementation. Gas-liquid chromatography was performed to analyze the fatty acids in hexane lipid extracts of whole rat brains.Supplementation with BLF did not induce signifi cant changes in fatty acid composition of whole brain phospholipids in rats fed the standard diet. In rats on high-fat diet concomitant (full-period) BLF supplementation increased eicosapentaenoic acid (20:5n-3, EPA), total n-6 and n-6/n-3 ratio, and decreased the percentage of oleic acid (18:1n-9) and estimated activity of Δ-9 desaturase. When BLF application was postponed (partial-period) in the case of developed hyperlipidemia, a decrease of stearic acid (18:0) accompanied with an increased estimated Δ-9 desaturase activity was observed. Regardless of BLF supplementation all high-fat diet-fed groups showed an elevated percentage of linoleic acid (18:2n-6, LA) and a reduced estimated Δ-6 desaturase activity.BLF contributes to the maintenance of stable fatty acid composition of brain phospholipids and supports normal brain function in high-fat diet rats, with more positive effects when BLF was applied before hyperlipidemia developed. This could be the mode of buckwheat health benefi cial effects on the brain.

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Effects Of Dietary Supplementation With A Mixture Of Buckwheat Leaf And Flower On Fatty Acid Composition Of Rat Brain Phospholipids

et al. 2015

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“…The reduced levels of C2 GPx and C2 CAT activities were the effect of raised and overwhelming levels of ROS (El-Demerdash et al, 2005;Avti et al, 2006); ROS has inhibitory effect on ROS scavenging enzymes such as CAT and GPx activities (Hassan and Fridovich, 1978;Avti et al, 2006). Consequently, raised levels of cytotoxic ROS engendered membrane lipid peroxidation with the production of associated by-products such as malondialdehyde (MDA) and 4-hydroxyalkenals (4HNE) (Shaker et al, 2010;Al-Dosari, 2011;Đurendić-Brenesel et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that Buckwheat (Fagopyrum esculentum) (Đurendić-Brenesel et al, 2013), Ocimum sanctum L. (Suanarunsawat et al, 2011) and Roselle (Hibiscus sabdariffa Linn) (Ochani and D'Mello, 2009) share similar antioxidant phytochemical profile with A. sativa extract (Ibegbulem and Chikezie, 2013). Accordingly, the presence of phytochemicals such phenolics, tannins and flavonoids in A. sativa extract, coupled with high content of antioxidant elementselenium (http.//www.completeherbal.com/details/garlic.htm; Banerjee and Maulik, 2002) contributed to the antioxidant property ofA.sativa extract.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of Allium sativa extract against carbon tetrachloride- induced hepatic oxidative stress and hyperlipidemia in rats

Chikezie¹,

Amadikwa²

2014

Afr. J. Biotechnol.

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Pathogenesis of several chronic liver diseases has been attributed to overwhelmed antioxidant protective system against reactive oxygen species (ROS). The present study ascertained the capacity of short-term administration of ethanolic extract of Allium sativa to neutralize ROS and ameliorate hyperlipidemia. Hyperlipidemia was induced in rats by single intra-peritoneal injection of CCl 4 (dosage = 2.0 mL/kg), followed by treatment with ethanolic extract of A. sativa (dosage: 200 and 400 mg/kg) at a regular interval of 16 for 64 h. Blood samples were drawn from the rats at t = 0 h and t = 76 h, that is, 12 h after the end of 64 h treatment with CCl 4 /A. sativa extract, to ascertain for hepatic function and serum lipid profile (SLP). In addition, liver post mitochondrial supernatant (PMS) fraction was measured for oxidative stress indicators: lipid peroxidation (LPOx), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and reduced glutathione (GSH). On the average, short-term administration of ethanolic extract of A. sativa caused reduction of SLP in the following magnitude: total cholesterol (TC) = 19.48%, triacylglycerol (TAG) = 48.59%, VLDL-C = 48.57%, LDL-C = 19.49% and increase in HDL-C = 32.43%. Also, improvement in oxidative stress indicators gave SOD = 10.20%, GPx = 30.92%, CAT = 18.18%, LPOx = 35.92% and GSH = 51.09%. Although the administration of A. sativa extract to the rats did not restore full therapeutic benefits within the experimental time (t = 76 h), the capacity of the plant extract to ameliorate oxidative stress and hyperlipidemia in the animals was fairly at par with the standard hepatic drug-hepaticum.

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“…Đurendić‐Brenesel et al examined the effects of buckwheat leaf and flower on plasma lipid status and phospholipid fatty acid composition, histology and parameters of oxidative stress in Wistar rats fed a high‐fat diet . The study showed that buckwheat leaf and flower mixture supplementation significantly reduced weight gain, plasma lipid concentrations and atherogenic index in rats fed a high‐fat diet.…”

Section: Other Buckwheat Productsmentioning

confidence: 99%

Hypolipidemic activity of common (Fagopyrum esculentum Moench) and tartary (Fagopyrum tataricum Gaertn.) buckwheat

2014

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Buckwheat grain has well-balanced nutritional value, whereas its digestibility is relatively low. This review summarizes recent advances in studies on the hypolipidemic activity of buckwheat. The most remarkable function is a powerful hypocholesterolemic activity of buckwheat protein in rats, which is far stronger than that of soy protein. The cholesterol-lowering effect is mediated by mechanisms involving higher excretion of fecal sterols and lower digestibility of buckwheat protein. The insoluble fraction of buckwheat protein associates with cholesterol and reduces micelle cholesterol uptake in caco-2 cells. Furthermore, consumption of buckwheat protein suppresses cholesterol-induced gallstones and body fat in rodents. Buckwheat sprouts also have hypolipidemic activity in rats or type 2 diabetic mice. Tartary buckwheat bran extract reduced the serum level of total cholesterol and triglyceride in hyperlipidemic rats. The consumption of buckwheat seed reduced low-density lipoprotein cholesterol in the pastureland Mongolian population. Taken together, buckwheat may be beneficial for prevention of hyperlipidemia.

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Hypolipidemic and antioxidant effects of buckwheat leaf and flower mixture in hyperlipidemic rats

Cited by 24 publications

References 0 publications

Effects Of Dietary Supplementation With A Mixture Of Buckwheat Leaf And Flower On Fatty Acid Composition Of Rat Brain Phospholipids

Effects Of Dietary Supplementation With A Mixture Of Buckwheat Leaf And Flower On Fatty Acid Composition Of Rat Brain Phospholipids

Protective effect of Allium sativa extract against carbon tetrachloride- induced hepatic oxidative stress and hyperlipidemia in rats

Hypolipidemic activity of common (Fagopyrum esculentum Moench) and tartary (Fagopyrum tataricum Gaertn.) buckwheat

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