Hypolipidemic Activity of Olive Oil (Olea europaea) against High Fat Diet-Induced Nonalcoholic Fatty Liver Disease (NAFLD) in Mice

Wani, Farooq Ahmed; Albahrawy, Abdalla Z.; Rahiman, Shaik

doi:10.4236/ojpathology.2015.53011

Cited by 13 publications

(11 citation statements)

References 41 publications

(41 reference statements)

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“…Our results are also similar with Necib et al (2013) who reported significant (P<0.01) decreased in the serum ALT activities after treating the rats with olive oil 2 ml. The variable effects of olive oil supplementation on biochemical constituents of Teddy buck and other animals or bird might be due to variation in enzymatic differences in the digestive process Our results shown that serum triglyceride significantly decrease (P<0.05) as compared to untreated group which are in line with Wani et al (2015) who reported the consequence of olive oil in contradiction of high fat diet in mice. The significant (P<0.05) reduction in triglycerides level in olive oil groups linked to assembly treated with high fat diet.…”

Section: Table 1 Serum Biochemical Metabolites and Hormonal Profile supporting

confidence: 89%

Effects of feed supplementation with olive oil on serum testosterone, triiodothyronine, thyroxine and some biochemical metabolites in Teddy goat bucks

Farooq¹,

Ali²,

Jamil³

et al. 2017

EJEA

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Teddy is highly proliferative goat breed, as female of this breed are famous for high twining rates. Feed supplementation of olive oil has been shown to improve semen quality of goat bucks. In this study, the effect of feed supplementation with olive oil on serum testosterone, triiodothyronine (T3), thyroxine (T4) and some biochemical metabolites in teddy goat bucks were investigated. For this purpose, 9 adult male goats, with clinically normal reproductive tract, were randomly separated into by three equal assemblies A, B and C. Animals in Cluster A were fed control ration (control group), whereas goats in group B and C were nourished with complemented 15 and 30 ml Olive oil, respectively, in morning daily for 8 weeks. Blood was collected weekly from each experimental animal and analyzed for serum testosterone, T3 and T4 concentration through ELISA. Similarly, serum alanine aminotransferase (ALT), Aspartate aminotransferase (AST), total cholesterol, triglycerides and glucose were determined using commercially available kits. Results revealed that serum concentrations of testosterone, T3 and T4 were higher (P<0.05) in bucks of groups B and C compared to those of control group. However, differences in concentration of these hormones between bucks of the former two groups were non-significant. Among biochemical metabolites, serum ALT, total cholesterol and triglycerides differed significantly (P<0.05) among three groups, with highest in control group and lowest in group C. Serum AST activity was also lower in bucks of assembly B and C than control, but, changes between groups B and C were non-significant. Similarly, the treatment had no effect on serum glucose concentrations. Based on results of the present studies, it was concluded that feed supplementation of olive oil improves semen quality and libido of Teddy goat bucks. However, its effects on health biomarkers and fertility rates of buck may be investigated before making any recommendation.

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Section: Table 1 Serum Biochemical Metabolites and Hormonal Profile supporting

confidence: 89%

Effects of feed supplementation with olive oil on serum testosterone, triiodothyronine, thyroxine and some biochemical metabolites in Teddy goat bucks

Farooq¹,

Ali²,

Jamil³

et al. 2017

EJEA

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“…In the present study, PO lowered serum TG levels without affecting serum TC levels. According to a previous report, OO has hypolipidemic activity [ 21 ]. In the present study, compared with HFD, HOO group showed reduced TG levels, however TC level was not significantly different.…”

Section: Discussionmentioning

confidence: 99%

Effect of vegetable oils with different fatty acid composition on high-fat diet-induced obesity and colon inflammation

2020

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BACKGROUND/OBJECTIVES: Different fatty acids exert different health benefits. This study investigated the potential protective effects of perilla, olive, and safflower oils on high-fat diet-induced obesity and colon inflammation. MATERIALS/METHODS: Five-week old, C57BL/6J mice were assigned to 5 groups: low-fat diet (LFD), high-fat diet (HFD) and high-fat diet supplemented with-perilla oil (HPO), olive oil (HOO), and safflower oil (HSO). After 16 weeks of the experimental period, the mice were sacrificed, and blood and tissues were collected. The serum was analyzed for obesity-and inflammation-related biomarkers. Gene expression of the biomarkers in the liver, adipose tissue, and colon tissue was analyzed. Micro-computed tomography (CT) analysis was performed one week before sacrifice. RESULTS: Treatment with all the three oils significantly improved obesity-induced increases in body weight, liver weight, and epididymal fat weight as well as serum triglyceride and leptin levels. Treatment with perilla oil (PO) and safflower oil (SO) increased adiponectin levels. The micro-CT analysis revealed that PO and SO reduced abdominal fat volume considerably. The mRNA expression of lipogenic genes was reduced in all the three oilsupplemented groups and PO upregulated lipid oxidation in the liver. Supplementation of oils improved macroscopic score, increased colon length, and decreased serum endotoxin and proinflammatory cytokine levels in the colon. The abundance of Bifidobacteria was increased and that of Enterobacteriaceae was reduced in the PO-supplemented group. All three oils reduced proinflammatory cytokine levels, as indicated by the mRNA expression. In addition, PO increased the expression of tight junction proteins. CONCLUSIONS: Taken together, our data indicate that the three oils exert similar anti-obesity effects. Interestingly, compared with olive oil and SO, PO provides better protection against high-fat diet-induced colon inflammation, suggesting that PO consumption helps manage inflammation-related diseases and provides omega-3 fatty acids needed by the body.

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“…Our results using olive oil are comparable to previous studies using different animal models [ 40 – 43 ]. For example, Wani et al [ 42 ] induced hepatic steatosis in mice using a high fat diet (42 % of energy as fat; over 16 weeks). Administration of olive oil with the high fat diet decreased weight gain, serum triglycerides, normalized liver enzyme levels, and decreased hepatic steatosis.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of the modulation of fructose/sucrose-induced hepatic steatosis by mixed lipid formulations varying in unsaturated fatty acid content

Siddiqui

Harvey

et al. 2015

Nutr Metab (Lond)

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BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries. NAFLD encompasses a spectrum of diseases, ranging from hepatic steatosis to non-alcoholic steatohepatitis (NASH), cirrhosis, and liver failure. The etiology of NAFLD remains unclear but is thought to relate to increased fatty acid flux within the liver that results in toxic fatty acid metabolite production. One source of increased fatty acid flux is fructose/sucrose-induced hepatic lipogenesis. Current treatment for NAFLD encompasses dietary modifications. However, little scientific evidence exists on which to base many dietary recommendations, especially the intake of different types of carbohydrates and fats. We hypothesized that lipid mixtures of unsaturated fatty acids would inhibit lipogenesis and subsequent hepatic steatosis induced by high carbohydrate diets. The aim of this study was to examine the effects of different complex mixtures of fatty acids upon the development of fructose/sucrose-induced hepatic steatosis.MethodsC57BL/6 mice were randomized to normocaloric chow-based diets that varied in the type of carbohydrate (starch, sucrose, fructose). Animals in each carbohydrate group were further randomized to diets that varied in lipid type (no additional lipid, soybean oil, fish oil, olive/soybean oil, macadamia nut oil). These oils were chosen based upon their content of omega-6 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, omega-9 monounsaturated fatty acids, or omega-7 monounsaturated fatty acids. Fatty acid flux in the liver was determine by assessing hepatic lipid content (steatosis). We also assessed fatty acid levels in the plasma and liver of the animals, hepatic lipogenesis activity, hepatic stearoyl-CoA-1 desaturase activity, and hepatic elongase activity.ResultsAnimals consumed similar amounts of the diets and maintained normal body weights throughout the study. Both sucrose and fructose induced hepatic lipogenesis and steatosis, with fructose being more potent. All mixed lipids similarly inhibited steatosis, limiting lipid content to levels found in the control (starch) animals. Lipogenesis and stearoyl-CoA-1 desaturase activity were increased in the sucrose and fructose groups. Levels of these enzymatic processes remained at baseline in all of the lipid groups.ConclusionThis is the first study to compare various complex lipid mixtures, based upon dietary oils with different types of long-chain fatty acids, upon development of sucrose/fructose-induced steatosis. Both carbohydrate source and lipid content appear important for the modulation of steatosis. Moderate intake of complex lipids with high unsaturated to saturated fatty acid ratios inhibited both lipogenesis and steatosis.

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Hypolipidemic Activity of Olive Oil (Olea europaea) against High Fat Diet-Induced Nonalcoholic Fatty Liver Disease (NAFLD) in Mice

Cited by 13 publications

References 41 publications

Effects of feed supplementation with olive oil on serum testosterone, triiodothyronine, thyroxine and some biochemical metabolites in Teddy goat bucks

Effects of feed supplementation with olive oil on serum testosterone, triiodothyronine, thyroxine and some biochemical metabolites in Teddy goat bucks

Effect of vegetable oils with different fatty acid composition on high-fat diet-induced obesity and colon inflammation

Comparative study of the modulation of fructose/sucrose-induced hepatic steatosis by mixed lipid formulations varying in unsaturated fatty acid content

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