Hypolipidemic Activity of Methanolic Extract of Terminalia arjuna Leaves in Hyperlipidemic Rat Models

Reddy, Devaraj; Kumar, Pradeep; Bharavi, K; Venkateswa, U.

doi:10.3923/rjmsci.2011.172.175

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…Despite the difference in the distribution and lipoprotein metabolism between humans and laboratory rats, models of hypercholesterolemic Wistar rats are frequently used in lipid research (Kothiyal and Gupta, 2011 ▶ ). Many studies have been made to propose alternative treatment based on plant species (Kothiyal and Gupta, 2011 ▶ ; Reddy et al, 2011 ▶ ; Patel et al, 2012 ▶ ; Sodipo et al, 2012 ▶ , Ghorbani, 2013 ▶ ). In Benin, a vegetable ( S. macrocarpon ), is reported to have cholesterol-lowering properties.…”

Section: Introductionmentioning

confidence: 99%

Treatment of hypercholesterolemia: screening of Solanum macrocarpon Linn (Solanaceae) as a medicinal plant in Benin

Dougnon

Bankolè

Baba-Moussa

et al. 2018

Proceedings for Annual Meeting of the Japanese Pharmacological Society

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Objective: Hypercholesterolemia is the greatest risk factor for cardiovascular diseases. The present study is conducted to evaluate the lipid lowering activity of leaves and fruits of Solanum macrocarpon, a vegetable, on Wistar rats experimentally rendered hypercholesterolemic by Triton X-100. Materials and Methods: The leaves and fruits were administered (p.o.) for 7 days to rats at doses of 400 and 800 mg/kg of body weight. Atorvastatin was used as reference treatment drug. The data were analyzed by the Brown-Forsythe ANOVA, Dunnett’s T3 multiple comparison test, and Dunnett’s t test. All tests were done at the 5% significance level. Results: Administration of S. macrocarpon (fruits as well as leaves) resulted in a statistically significant decrease in total cholesterol, LDL-cholesterol, VLDL-cholesterol, and triglycerides in the treated groups compared with the untreated hypercholesterolemic group, regardless of the administrated doses. A significant increase in HDL-cholesterol was observed in the treated groups. Hepatic disorders due to the Triton have been corrected by S. macrocarpon . Conclusions : This vegetable effectively suppresses experimental hypercholesterolemia in Wistar rats, suggesting a protective role in cardiovascular diseases. Its use by individuals at risk should be promoted.

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Section: Introductionmentioning

confidence: 99%

Treatment of hypercholesterolemia: screening of Solanum macrocarpon Linn (Solanaceae) as a medicinal plant in Benin

Dougnon

Bankolè

Baba-Moussa

et al. 2018

Proceedings for Annual Meeting of the Japanese Pharmacological Society

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“…Use of medicinal plants as a pharmacologic modality in preventing alteration in lipid metabolism has received wide attention from several workers 19 . Rats fed with a diet supplemented with 5 g cholesterol and 5 g deoxycholic acid in butter for 45 days served as the experimental model 10 .…”

Section: Discussionmentioning

confidence: 99%

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2019

IJPSR

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To assess the effect of Perillyl alcohol (POH) on the lipid profile of high-fat-diet-induced hyperlipidemia in white male albino Wistar rats, the hyperlipidemia was induced by feeding cholesterol-rich high-fat diet for 45 days in male albino Wistar rats. The decline in the triglycerides, LDL and VLDL was significant at 100 & 200 mg/kg dose of POH compared to Atorvastatin group. The decrease in total cholesterol was significant at 100 and 200 mg/kg doses compared to hyperlipidemic control. The results demonstrate that POH at a dose of 100 and 200 mg/kg body weight lowers the serum triglyceride, LDL, VLDL, total cholesterol and increase HDL level significantly in high-fat-diet-induced hyperlipidemic rats. Though there was no significant effect on the lipid profile at 50 mg/kg dose. Thus, the results of the present study provide scientific validation for the use of Perillyl alcohol (POH) a terpene as an Antihyperlipidemic agent.

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“…Though many reports are available on the efficacy of T.arjuna bark extract in hyperlipidemic states, presence of the same activity in its leave was not extensively reported. [16] T.arjuna has been known to possess cardiovascular benefits as early as 500 BC and its bark has been used in Indian traditional system of medicine for over three centuries as a cardiotonic. Active constituents of Terminalia bark include tannins, cardenolide, triterpenoid saponins (arjunic acid, arjunolic acid, arjungenin and arjunglycosides), flavonoids (arjunone, arjunolone and luteolin), gallic acid, ellagic acid, oligomericproanthocyanidins, phytosterols and various minerals such as calcium, magnesium, zinc and copper.…”

Section: Modifiable Risk Factorsmentioning

confidence: 99%

To Compare the Effects of Terminalia Arjuna with Rosuvastatin on Total Cholesterol and Low Density Lipoprotein Cholesterol

Prakash

Sehgal

Bajaj

et al. 2016

IJMDS

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Hypolipidemic Activity of Methanolic Extract of Terminalia arjuna Leaves in Hyperlipidemic Rat Models

Cited by 4 publications

References 3 publications

Treatment of hypercholesterolemia: screening of Solanum macrocarpon Linn (Solanaceae) as a medicinal plant in Benin

Treatment of hypercholesterolemia: screening of Solanum macrocarpon Linn (Solanaceae) as a medicinal plant in Benin

Untitled

To Compare the Effects of Terminalia Arjuna with Rosuvastatin on Total Cholesterol and Low Density Lipoprotein Cholesterol

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