Hypolipidemia: a study evaluating magnitude and underlying etiologies of the entity

Abstract

Background: Hyperlipidemia is a common and well-known entity as it is one of the risk factors of various noncommunicable diseases. Hypolipidemia is an entity which is very less known among health care givers. Currently available data about this entity is insufficient and nonconclusive.Methods: This study was a prospective observational study. Lipid profile reports at the central lab of the institute was observed and among them hypolipidemia reports and related patients were identified. Patients were further evaluated and classified into 10 etiological categories.Results: Total 450 lipid profile reports were observed out of which 36 (8%) reports had hypolipidemia. Most patients had hypolipidemia were having chronic illness (41.7%) or critical illness (33.3%) followed by malnutrition (11.1%), idiopathic etiology (11.1%), moderate to severe anemia (8.3%), chronic liver disease (8.3%), cancer (5.5%), statin use for more than 3 months (2.8%), malabsorption (2.8%), hyperthyroidism (0%).Conclusions: Awareness about hypolipidemia among health care givers is needed to look out for underline diseases with consequences and to have active participation to unsolved the mystery of this entity. Overuse of antihyperlipidemic drugs should be avoided. This study highlighted causes and consequences of hypolipidemia.

Microplastics exposure altered hematological and lipid profiles as well as liver and kidney function parameters in albino rats (Rattus norvegicus)

“…The increase in the lipid profile is termed hyperlipidemia, possibly caused by a dietary disorder [ 48 ] or renal failure or physical inactivity [ 49 ] induced by microplastics. The decrease observed in the lipid profile of rats dosed with 10% microplastic solution is termed hypolipidemia, possibly caused by liver dysfunction or chronic inflammation or malabsorption or malnutrition [ 50 , 51 ] induced by microplastics ingestion. Feeding habits, in particular, have been demonstrated by Cole et al [ 52 ] to alter in Coldwater copepod following microplastic exposure, resulting in an altered lipid profile.…”

A case of suspicious fatty liver and seven non-fatty liver cases with hypobetalipoproteinemia, experienced in a community cohort

“…Apo B was lower than the reference value, and AST/ALT was 0.55, suspecting fatty liver laboratory findings. There were no symptoms or findings of small intestinal mala�sorption, malnutrition, malignant disease, or hyperthyroidism [3][4][5], which are thought to �e secondary causes of �ypocholesterolemia. Though the patient had only mild hypertension and no history of hepatitis, we attri�uted the elevated AST and A�T levels and decreased AST/A�T ratio to fatty liver.…”

Cholesterol Level in Covid-19 Patients Related to Severity and Mortality: A Case Series and Literature Review

“…Several other studies used the median or cut-off obtained in their research. 9,13 There are three causes of primary hypolipidemia that rarely occur abetalipoproteinemia, hypobetalipoproteinemia, and chylomicron retention disease. Secondary hypolipidemia occurs more often and may be caused by acute or chronic infection, malabsorption, malnutrition, anemia, critical illness, chronic inflammation, malignancy, hyperthyroidism, chronic liver disease, and the effect of therapy with statin.…”

“…Secondary hypolipidemia occurs more often and may be caused by acute or chronic infection, malabsorption, malnutrition, anemia, critical illness, chronic inflammation, malignancy, hyperthyroidism, chronic liver disease, and the effect of therapy with statin. 13,14 In acute or chronic bacterial infection, viral infection and parasite infection may cause hypolipidemia/ hypocholesterolemia because of the pro-inflammatory cytokine effect on lipoprotein metabolism. 15 In 2012,…”