Hypolipidaemic activity of orally administered diphenyl diselenide in Triton WR-1339-induced hyperlipidaemia in mice

Rocha, Juliana Trevisan da; Sperança, Adriane; Nogueira, Cristina Wayne; Zeni, Gilson

doi:10.1211/jpp.61.12.0013

Cited by 32 publications

(26 citation statements)

References 52 publications

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“…To screen the hypolipidemic effect of natural or chemical drugs, Triton WR-1339 (Sigma-Aldrich, St. Louis, MO, U.S.A.) has been widely used to induce acute hyperlipidemia in animal models in doses ranging from 200 to 400 mg/kg. 15) In this study a dose of 300 mg/kg of Triton WR-1339 dissolved in water was given intraperitoneally to the rats. 16) Pharmacological Experimental Design Overnight forty-eight fasted rats were randomly divided into six groups each consisting of eight animals.…”

Section: Induction Of Hyperlipidemia By Triton Wr-1339mentioning

confidence: 99%

Synthesis and <i>in Vivo</i> Lipid-Lowering Activity of Novel Imidazoles-5-carboxamide Derivatives in Triton-WR-1339-Induced Hyperlipidemic Wistar Rats

Jasim

Sheikha

Abuzaid

et al. 2018

CHEMICAL & PHARMACEUTICAL BULLETIN

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A new series of imidazole-5-carboxamide derivatives were prepared and tested for their anti-hyperlipidemic activity in Triton-WR-1339-induced hyperlipidemic Wistar rats. The purpose of this research was to improve benzophenone carboxamides water solubility maintaining at the same time the antihyperlipidemic activity. Compounds 4, 6, 10, and 11 were synthesized through a coupling reaction between imidazoles-5-carbonyl chloride and amino benzophenones. The tested animals (n 48) were divided into six groups: the first group (hyperlipidemic control group; HCG) received an intraperitoneal injection (i.p.) of (300 mg/kg) Triton WR-1339. The second group received i.p. injection of Triton WR-1339 followed by an intra-gastric administration of bezafibrate (100 mg/kg) (bezafibrate; BF). The third, fourth, fifth, and sixth groups received i.p. injection of Triton WR-1339 followed by an intra-gastric administration of (30 mg/kg) of compounds 4, 6, 10, and 11, respectively. At a dose of 30 mg/kg body weight compounds 4, 6, 10, and 11 significantly (p<0.0001) decreased the plasma level of triglyceride (TG), low-density lipoprotein (LDL) and total cholesterol (TC) levels after 18 h of treatment. Additionally, compounds 4, 6, 11 and bezafibrate (100 mg/kg) significantly (p<0.0001) increased the plasma level of high-density lipoprotein (HDL) levels, which is known for its preventive role against atherogenesis. These results demonstrate the possibility of pharmacokinetic properties improvement maintaining the biological and pharmacological profile of these compounds.

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Section: Induction Of Hyperlipidemia By Triton Wr-1339mentioning

confidence: 99%

Synthesis and <i>in Vivo</i> Lipid-Lowering Activity of Novel Imidazoles-5-carboxamide Derivatives in Triton-WR-1339-Induced Hyperlipidemic Wistar Rats

Jasim

Sheikha

Abuzaid

et al. 2018

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…In fact, the effects of (PhSe) 2 on lipid profile is dependent of the experimental model used. For example, we observed that (PhSe) 2 was able to decrease the plasma cholesterol levels in rabbits fed with cholesterol diet as the oral treatment with (PhSe) 2 had a hypolipidaemic effect in Triton WR‐1339‐induced hyperlipidemia in mice . On the other hand, in this hypercholesterolemic mice model, we did not observe any changes in lipid profile after (PhSe) 2 treatment; then we can suppose that the anti‐atherogenic effect of this compound can be related to its effective antioxidant property.…”

Section: Discussionmentioning

confidence: 77%

Diphenyl diselenide differently modulates cardiovascular redox responses in young adult and middle-aged low-density lipoprotein receptor knockout hypercholesterolemic mice

Mancini

Oliveira

Hort

et al. 2013

Journal of Pharmacy and Pharmacology

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“…Several reviews from our laboratory have focused on this topic [159-161]. Briefly, organoselenium compounds have been shown to possess glutathione peroxidase-mimetic activity [162-166], lipid peroxidation/radical-scavenging/peroxynitrite-scavenging activity [167-171], thioredoxin reductase-like activity [172-176], antiinflammatory and antinociceptive activity [177-181], antinociceptive activity [182-186], hepatoprotective activity [187-191], gastroprotective activity [192-196], nephroprotective activity [197-201], cardioprotective activity [202-206], insulin-mimetic activity [207-211], and neuro-protective activity [212-218] (Scheme 3 ).…”

Section: Future Directionsmentioning

confidence: 99%

Association of Oxidative Stress to the Genesis of Anxiety: Implications for Possible Therapeutic Interventions

Hassan¹,

Silva²,

Mohammadzai³

et al. 2014

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Oxidative stress caused by reactive species, including reactive oxygen species, reactive nitrogen species, and unbound, adventitious metal ions (e.g., iron [Fe] and copper [Cu]), is an underlying cause of various neurodegenerative diseases. These reactive species are an inevitable by-product of cellular respiration or other metabolic processes that may cause the oxidation of lipids, nucleic acids, and proteins. Oxidative stress has recently been implicated in depression and anxiety-related disorders. Furthermore, the manifestation of anxiety in numerous psychiatric disorders, such as generalized anxiety disorder, depressive disorder, panic disorder, phobia, obsessive-compulsive disorder, and posttraumatic stress disorder, highlights the importance of studying the underlying biology of these disorders to gain a better understanding of the disease and to identify common biomarkers for these disorders. Most recently, the expression of glutathione reductase 1 and glyoxalase 1, which are genes involved in antioxidative metabolism, were reported to be correlated with anxiety-related phenotypes. This review focuses on direct and indirect evidence of the potential involvement of oxidative stress in the genesis of anxiety and discusses different opinions that exist in this field. Antioxidant therapeutic strategies are also discussed, highlighting the importance of oxidative stress in the etiology, incidence, progression, and prevention of psychiatric disorders.

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Hypolipidaemic activity of orally administered diphenyl diselenide in Triton WR-1339-induced hyperlipidaemia in mice

Abstract: These findings indicated that (PhSe)(2) was able to lower plasma lipid concentrations. Further studies are needed to elucidate the exact mechanism by which (PhSe)(2) exerted its hypolipidaemic effect in the management of hyperlipidaemia and atherosclerosis.

Cited by 32 publications

References 52 publications

Synthesis and <i>in Vivo</i> Lipid-Lowering Activity of Novel Imidazoles-5-carboxamide Derivatives in Triton-WR-1339-Induced Hyperlipidemic Wistar Rats

Synthesis and <i>in Vivo</i> Lipid-Lowering Activity of Novel Imidazoles-5-carboxamide Derivatives in Triton-WR-1339-Induced Hyperlipidemic Wistar Rats

Diphenyl diselenide differently modulates cardiovascular redox responses in young adult and middle-aged low-density lipoprotein receptor knockout hypercholesterolemic mice

Association of Oxidative Stress to the Genesis of Anxiety: Implications for Possible Therapeutic Interventions

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