Hypolipemic Effect of Garcinia cambogia in Obese Women

Abstract

Garcinia cambogia seems to promote weight reduction and improvement on lipid profile by its major compound, hydroxycitric acid (HCA), blocking ATP-citratelyase, potentially inhibiting lipogenesis. Furthermore, it is suggested that its extract is able to change the adipokine levels. Thus, the aim of this study was to analyse the effect of G. cambogia on the lipid profile, endocrine, calorimetric and anthropometric parameters of obese women. The women (BMI > 25 kg/m(2) ; age 25-60 years), divided in treated (n = 30) and control (n = 13) groups, received 2.4 g (800 mg 3×/day) of garcinia extract (50% of HCA) or placebo during 60 days, respectively, as well as dietary control. Weight, BMI, waist-hip ratio and percentage of fat mass, resting metabolic rate, respiratory coefficient, triglycerides (TG), total cholesterol, HDL and LDL, leptin and insulin serum levels were evaluated. TG was significantly reduced in the treated group (p = 0.0002) and the post-treatment variation was different compared to the placebo group (p = 0.04). No significant response was observed on other variables of the lipid profile, or on the anthropometric and calorimetric parameters. Leptin and insulin levels did not change significantly after the treatment. The short-term treatment with G. cambogia demonstrated a hypotriglyceridemic effect, which does not appear to be related to changes in leptinemia.

Suppression of fat deposition in broiler chickens by (-)-hydroxycitric acid supplementation: A proteomics perspective

“…This enzyme catalyzes the cleavage of citrate to oxaloacetate and acetyl-CoA and eventually limits the availability of acetyl-CoA units required for fatty acid synthesis and lipogenesis1020. However, the underlying biochemical mechanisms are not well understood; in particular, there is no detailed information available on the effect of (-)-HCA in broiler chickens.…”

“…Recently, our laboratory also found that Garcinia cambogia extracts could attenuate fat accumulation through regulation of lipolysis gene expression via the adiponectin-AMPK signaling pathway in a rat obesity model induced by a high-fat diet17. Further, previous studies have shown that in animals and humans, (-)-HCA is a potent inhibitor of ATP-citrate lyase1819, which catalyzes the cleavage of citrate to oxaloacetate and acetyl-CoA and eventual limits the availability of the acetyl-CoA units required for fatty acid synthesis and lipogenesis1020. However, the underlying biochemical mechanism is not well understood, especially the effects of (-)-HCA in broiler chickens.…”

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

“…(-)-Hydroxycitric acid (HCA) is widely used as an ingredient for a nutritional supplement to control body weight gain and inhibit fat accumulation in humans [23, 47-49] and animals [25, 50, 51]. (-)-HCA-containing products have been on the market for many years [18, 27].…”

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

“…In addition, some studies have recognized the effectiveness of herbal plants on body fat percent (BF%), fat mass (FM), and fat‐free mass (FFM). Also, significant decrease was seen in FM and BF% by green tea (green tea with dose of 6,000 mg/day and catechins with doses of 458, 468, and 886 mg/day; Tsai et al, , Wang et al, ), I. gabonensis (with dose of 300 mg/day; Ngondi et al, ), H. sabdariffa (with dose of 75 mg/day; Chang et al, ), Phaseolus Vulgaris (with dose of 445 mg/day; Celleno et al, , Perricone, ), G. cambogia (with doses of 2,400 and 3,000 mg/day [equivalent 1,200 and 1,500 mg hydroxycitric acid]; Heymsfield et al, , Vasques et al, ), Ecklonia cava (with doses of 72 and 144 mg/day; Shin, Kim, Park, Lee, & Hwang, ), cumin (with dose of 3,000 mg/day; Zare et al, ), Coleus forskolii (with dose of 250 mg/day; Loftus, Astell, Mathai, & Su, ), Sorghum tea (with dose of 1,000 ml/day) (Yokomichi, ), Gynostemma pentaphyllum (with dose of 450 mg/day; Park et al, ), and cinnamon (with dose of 550 mg/day; Vafa et al, ).…”