Hypokalemic periodic paralysis and renal tubular acidosis in a patient with hypothyroid and autoimmune disease

Permatasari, Cynthia Ayu; Zahraini, Harida; Marpaung, Ferdy Royland; Aryati,

doi:10.1016/j.amsu.2022.103389

Cited by 6 publications

(4 citation statements)

References 19 publications

(26 reference statements)

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“…Hypokalemia can produce paralysis for a variety of reasons in a variety of disorders. Excessive excretion of potassium, or redistribution into cells, can cause hypokalemic paralysis [ 13 ]. Wasting of potassium through kidneys and accompanying paralysis has been observed in various conditions, including nephrotic syndrome, Fanconi syndrome, primary aldosteronism, and RTA [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Late-Onset Hypokalemic Periodic Paralysis in an Adult Female With Type 2 Renal Tubular Acidosis: A Case Report

Chukwuedozie¹,

Garg²,

Chaudhry³

et al. 2022

Cureus

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Proximal renal tubular acidosis (type 2 RTA) is a metabolic disorder characterized by an inability of the proximal renal tubules to reabsorb bicarbonate, resulting in excessive urinary loss of bicarbonate. In return, this causes a standard anion gap metabolic acidosis with aberrant renal acidification, culminating in excessive urinary potassium loss and hyperchloremic metabolic acidosis. Several sources can induce potassium deficiency, ranging from slight abnormalities in potassium homeostasis to catastrophic and occasionally lethal circumstances. Hypokalemic periodic paralysis (HPP) manifests with broad muscle weakness and the absence of deep tendon reflexes, with the facial, bulbar, and respiratory muscles spared, and it subsequently requires the administration of intravenous potassium chloride to address the potassium imbalance. Some patients suffering from chronic potassium shortage may have periods of weakness. The clinical symptoms of distal RTA are identical to those of attacks induced by familial hypokalemic periodic paralysis (FPP). Muscle weakness may begin slowly and worsen over 24-48 hours to flaccid quadriplegia. RTA and FPP typically spare speech, swallowing, and ocular and respiratory muscles. As a result, families with RTA children must be aware of this risk. We present a case of HPP in a female caused by type 2 RTA.

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Section: Discussionmentioning

confidence: 99%

Late-Onset Hypokalemic Periodic Paralysis in an Adult Female With Type 2 Renal Tubular Acidosis: A Case Report

Chukwuedozie¹,

Garg²,

Chaudhry³

et al. 2022

Cureus

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“…In individuals susceptible to Sjogren's syndrome, activation of B cells can promote autoantibody production in germinal center (GC) like structures. Epithelial cells release ribonucleoprotein autoantigens Ro/SSA and La/SSB which participate in the formation of immune complexes and in the continuous activation of the immune system and cause tissue damage (Endaryanto & Nugraha, 2021;Hertanto et al, 2021;Huldani et al, 2022;Kristanti et al, 2021;Nocturne & Mariette, 2013;Parisis et al, 2020;Permatasari et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Suspect recurrent transient ischemic attack ec Sjogren’s Syndrome

Mandrakitty

Tjandrawati

2022

ijhs

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Sjogren's Syndrome is a chronic systemic autoimmune disorder that is usually accompanied by dry eyes and mouth due to inflammation and abnormalities in the lacrimal and salivary glands. This disease can cause a decrease in the production of secretions in other organs that need moisture, such as the nose, throat, respiratory tract, and skin. The prevalence in the general population is not yet known, but the prevalence in the Americas is 0.05-4.8% of the population. Sixty percent of Sjogren's Syndrome patients have disease secondary to accompanying autoimmune disorders such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or systemic sclerosis.

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“…Matter Hamdy.matter@gmail.com fatigue, and cognitive symptoms, [8] Idiopathic pulmonary and hepatic fibrosis, [9] female sexual dysfunction, [10] schizophrenia, [11] and autoimmune diseases. [12] Furthermore, thyroid abnormalities increase the risk of compounded adverse outcomes for COVID-19 and affect the patient's age. Having a thyroid disorder or hypothyroidism, but not hyperthyroidism, has a poor outcome for COVID-19, [13] Levothyroxine.…”

Section: Introductionmentioning

confidence: 99%

A Prevalence of Thyroid Disorders at Al-Wahat Region of Libya During 2022

Matter,

Ayad,

Nofal

et al. 2023

sjuob

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About 1272 cases of thyroid hormones were examined. The study was conducted during the year 2022 in the Al-Wahat region / Libya, it was found that 10.5% suffer from a disorder in their hormones, 40% of these cases suffer from a deficiency in their hormones, and 60% of them suffer from an excess. The number of women who suffer from a disorder in their hormones was 81%, while the number of men was 19%, 48% of women with high, and those with low was 33%. In addition, 13% of the males with high and those with low was 6%. It was found that the high and low % increase as the normal distribution from the age of 30 to 70 for all cases of thyroid gland disorder with a mean of 44 years and a standard deviation S = 17.5 for high values, and 18.9 for low values. The variation coefficient of 39.7 and 42.9, and the most common age was (The mode) for the high is 40 years and for the low is 30 years. In other words, the high is greater than the low for them, and the mean in both cases is the age of 40. The most common values for the high are at 42 in general, while in low they have about 37 years, and the median in high is about 45 years, while in low is about 30 years. The high is higher for males than the low and the mean for high is 49 years, while for low is 60 years, and S = 20.2 for high and S = 27.7 for low, and there is no correlation between high or low between men and women as indicated by the measurement of Pearson's correlation coefficient.

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Hypokalemic periodic paralysis and renal tubular acidosis in a patient with hypothyroid and autoimmune disease

Cited by 6 publications

References 19 publications

Late-Onset Hypokalemic Periodic Paralysis in an Adult Female With Type 2 Renal Tubular Acidosis: A Case Report

Late-Onset Hypokalemic Periodic Paralysis in an Adult Female With Type 2 Renal Tubular Acidosis: A Case Report

Suspect recurrent transient ischemic attack ec Sjogren’s Syndrome

A Prevalence of Thyroid Disorders at Al-Wahat Region of Libya During 2022

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