Hypokalemic, Hypophosphatemic Thyrotoxic Periodic Paralysis

Nora, Nancy A.; Berns, Arnold S.

doi:10.1016/s0272-6386(89)80060-5

Cited by 27 publications

(14 citation statements)

References 11 publications

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“…Rebound hyperkalemia occurred in 42% of our 24 episodes of hospitalized patients with TPP, with a maximum serum K level of 6.6 mmol/L, and this phenomenon is well described in the literature. 4,6,[8][9][10]14,[23][24][25] Hypophosphatemia during paralysis in patients with TPP has been previously reported 8,16,24,26,27 and may contribute to the muscle weakness 28 along with hypokalemia. In our study, 12 (80%) of 15 episodes had decreased serum levels of P when first seen, and only 4 of the episodes (patients 7, 17, 23, and 24 in Table 1) received replacement therapy with neutra-phos.…”

Section: Commentmentioning

confidence: 99%

See 1 more Smart Citation

Clinical and Metabolic Features of Thyrotoxic Periodic Paralysis in 24 Episodes

Manoukian¹,

Foote²,

Crapo³

1999

Arch Intern Med

217

183

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Section: Commentmentioning

confidence: 99%

“…Mild hyperphosphatemia after paralysis has been previously observed. 24,27 Phosphorus is a major intracellular anion, and its influx Table 1 for definitions of (i) and (max).…”

Section: Commentmentioning

confidence: 99%

Clinical and Metabolic Features of Thyrotoxic Periodic Paralysis in 24 Episodes

Manoukian¹,

Foote²,

Crapo³

1999

Arch Intern Med

217

183

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“…In the United States, most patients with TTP are men of Asian descent, with relatively few reported cases in other ethnic groups including Whites, African-Americans, Hispanics, and American Indians (1)(2)(3)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). We report four cases of TPP in AfricanAmerican males diagnosed in our institution over a 13-year period (1980)(1981)(1982)(1983)(1984)(1985)(1986)(1987)(1988)(1989)(1990)(1991)(1992)(1993).…”

Section: Introductionmentioning

confidence: 99%

Thyrotoxic Hypokalemic Periodic Paralysis: Report of Four Cases in Black American Males1

Kilpatrick

Seiler-Smith²,

Levine³

1994

Thyroid

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Thyrotoxic periodic paralysis (TPP) is an unusual complication of a fairly common disease affecting mostly Asian males. In the United States, there have been several reports of TPP in different ethnic populations and it appears that the incidence is approximately one-tenth of that found in Asian countries. Only six reports of TPP in African-Americans could be found in the literature; however, we are reporting four cases diagnosed within a 13-year period at our institution. We conclude that TPP may occur more often in Blacks than previously suspected and should be considered when patients present with unexplained hypokalemia, muscular weakness and rhabdomyolysis. The epidemiology, clinical manifestations, pathophysiology, and treatment of TPP are reviewed.

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“…In a literature review of articles dealing with TPP, we found that propranolol given alone is reported to normalize serum potassium in an average of 120 min (three cases), whereas potassium therapy given alone takes an average of 393 min (13 cases) (9,16,(27)(28)(29)(30)(31)(32)(33)(34)(35). In addition, propranolol, used alone, does not result in rebound hyperkalemia.…”

Section: Discussionmentioning

confidence: 93%