Hypogonadism induced by surgical stress and brain trauma is reversed by human chorionic gonadotropin in male rats: A potential therapy for surgical and TBI‐induced hypogonadism?

Geddes, Rastafa I.; Kapoor, Amita; Hayashi, Kentaro; Rauh, Ryan; Wehber, Marlyse; Bongers, Quinn; Jansen, Alex D.; Anderson, Icelle M.; Farquhar, Gabrielle; Vadakkadath‐Meethal, Sivan; Ziegler, Toni E.; Atwood, Craig S.

doi:10.1002/edm2.239

Endocrino Diabet & Metabol

2021

DOI: 10.1002/edm2.239

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Hypogonadism induced by surgical stress and brain trauma is reversed by human chorionic gonadotropin in male rats: A potential therapy for surgical and TBI‐induced hypogonadism?

Rastafa I. Geddes

Amita Kapoor

Kentaro Hayashi

et al.

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Cited by 2 publications

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Functional hypogonadism in men: key causes and neuroendocrine mechanisms of its development

Salukhov,

Aisaeva

2024

Medicinskij sovet

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Modern concepts of hypogonadism in men are undergoing significant transformation. The concept of functional hypogonadism, which is gaining increasing support among expert communities today, is based on the reversibility of symptomatic hypotestosteronemia after eliminating the causal factor or disease in men with an intact hypothalamic-pituitary-gonadal system. This makes the diagnosis of functional hypogonadism an exclusion diagnosis of organic hypogonadism, which can be congenital (genetic) or acquired (destructive or structural) irreversible disorder occurring at any level of the hypothalamic-pituitary-gonadal axis. Functional hypogonadism in men is becoming more common, attributed to its association with non-infectious pandemics such as obesity, type 2 diabetes, and other comorbid pathologies. Additionally, age-related hypogonadism meets the criteria of functional hypogonadism, as accumulating age-associated comorbidities have been shown to play a significant role in testosterone decline in aging men. Moreover, excessive physical activity, drastic calorie restriction, high psycho-emotional stress, injuries, surgeries, and the use of certain medications can also be causes of functional hypogonadism. Despite the wide range and heterogeneity of diseases and conditions underlying functional hypogonadism, the mechanisms driving its development are quite similar since in most cases, this androgen deficiency is secondary hypogonadotropic (central). However, in some cases, functional hypogonadism can be primary or mixed. Therefore, understanding the pathogenesis of functional hypogonadism is crucial as it involves a variety of biological pathways depending on the etiological factor or disease, which is detailed through a literature review. The article pays special attention to the evolutionary significance of the phenomenon of functional hypogonadism, an adapted classification of its causes, and describes the achievements of Russian researchers who have studied the impact of acute conditions and extreme influences on the hypothalamic-pituitary-gonadal system in men.

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Functional hypogonadism in men: key causes and neuroendocrine mechanisms of its development

Salukhov,

Aisaeva

2024

Medicinskij sovet

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Brain Trauma, Glucocorticoids and Neuroinflammation: Dangerous Liaisons for the Hippocampus

Komoltsev

Gulyaeva

2022

Biomedicines

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Glucocorticoid-dependent mechanisms of inflammation-mediated distant hippocampal damage are discussed with a focus on the consequences of traumatic brain injury. The effects of glucocorticoids on specific neuronal populations in the hippocampus depend on their concentration, duration of exposure and cell type. Previous stress and elevated level of glucocorticoids prior to pro-inflammatory impact, as well as long-term though moderate elevation of glucocorticoids, may inflate pro-inflammatory effects. Glucocorticoid-mediated long-lasting neuronal circuit changes in the hippocampus after brain trauma are involved in late post-traumatic pathology development, such as epilepsy, depression and cognitive impairment. Complex and diverse actions of the hypothalamic–pituitary–adrenal axis on neuroinflammation may be essential for late post-traumatic pathology. These mechanisms are applicable to remote hippocampal damage occurring after other types of focal brain damage (stroke, epilepsy) or central nervous system diseases without obvious focal injury. Thus, the liaisons of excessive glucocorticoids/dysfunctional hypothalamic–pituitary–adrenal axis with neuroinflammation, dangerous to the hippocampus, may be crucial to distant hippocampal damage in many brain diseases. Taking into account that the hippocampus controls both the cognitive functions and the emotional state, further research on potential links between glucocorticoid signaling and inflammatory processes in the brain and respective mechanisms is vital.

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Hypogonadism induced by surgical stress and brain trauma is reversed by human chorionic gonadotropin in male rats: A potential therapy for surgical and TBI‐induced hypogonadism?

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 2 publications

References 105 publications

Functional hypogonadism in men: key causes and neuroendocrine mechanisms of its development

Functional hypogonadism in men: key causes and neuroendocrine mechanisms of its development

Brain Trauma, Glucocorticoids and Neuroinflammation: Dangerous Liaisons for the Hippocampus

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