Hypoglycemic response of blood to live Escherichia coli organisms and endotoxin

Hinshaw, Lerner B.; Beller, B. K.; Archer, L. T.; Benjamin, Bruce

doi:10.1016/0022-4804(76)90150-5

Cited by 21 publications

(9 citation statements)

References 8 publications

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“…Circulating endotoxin in the absence of bacteria or circulating endotoxin liberated from growing or antibiotic-killed bacteria has been measured in association with sepsis (5,15,55,65). Consequently, putative modulators of the sepsis syndrome are often evaluated for their ability to attenuate the effects of LPS administration to animals (3,28). Following the assessment of a modulator's effect after endotoxin administration, it often is next tested for its ability to alter the course of sepsis following the administration of live bacteria to the animals.…”

Section: Introductionmentioning

confidence: 99%

Choice of bacteria in animal models of sepsis

et al. 1993

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Section: Introductionmentioning

confidence: 99%

Choice of bacteria in animal models of sepsis

et al. 1993

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“…Compared to the more commonly used models where septic shock is induced by intravenous administration of bacteria or en dotoxin [e.g. 4,5], the present models may more closely mimic the clinical situation as we may find it postoperalively or postlraumatically. In the intraperitoneal E. coli injec tion model a standardized challenge is pre sented to the animal which makes it possible to predict the survival rate according to the number of bacteria injected.…”

Section: Discussionmentioning

confidence: 99%

“…To provide better understanding of the pathophysiologi cal mechanisms involved in the genesis of septic shock states, studies using different laboratory animal models have been suggest ed. Most often intravenous administration of endotoxin or live bacteria have been utilized as the shock-inducing agent [3][4][5][6][7], Recently, models have been proposed in which septic shock is induced by peritonitis [1,2,[8][9][10]. This study was performed to standardize such septic shock models and to compare septic shock induced by intraperitoneal injec tion of bacteria as suggested by Short et al [9] …”

mentioning

confidence: 99%

Peritonitis and Septic Shock – An Evaluation of Two Experimental Models in the Rat

Martinell¹,

Falk²,

Haglund³

et al. 1985

Eur Surg Res

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Two different experimental models for inducing septic shock have been characterized. In one, septic shock was induced by intraperitoneal injection of live Escherichia coli bacteria. This resulted in a dose-dependent mortality. Those animals surviving the first 24 h are considered as permanent survivors. In the other models, septic shock and peritonitis was induced by ligation and needle punctures of the cecum. This resulted in a slower development of shock which was almost invariably lethal within 96 h. Arterial blood pressure remained within the normal range in both models for up to 3 h after inducing peritonitis. Then a rapid deterioration was noticed in animals injected with live E. coli. White blood cells and platelets in arterial blood were reduced compared to controls in both groups. This reduction was more pronounced in animals injected with live E. coli. Both models are considered as useful tools in further studies of the pathophysiology of peritonitis and septic shock.

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“…Preparation of a sepsis model (Hinshaw et al 1968) : Escherichia coil strain 5 X 109 CFU/ml/kg was intravenously infused over a 1-hr period to 22 mongrel puppies weighing 1.8-3.2 kg. They were divided into the following four groups :…”

Section: Methodsmentioning

confidence: 99%