Hypoglycemic Potential of Benzimidazole Derivatives

Spasov, A. A.; Lenskaya, K. V.; Vasil’ev, P. M.

doi:10.1007/s11094-015-1313-x

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…In previous papers we have described our efforts to discover and develop novel antidiabetic agents [3][4][5]. Azolo annelated [1,2,4]triazines can be considered as isosteres of purine bases.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1‐c][1,2,4]‐triazines and Pyrazolo[5,1‐c][1,2,4]triazines as Potential Antidiabetic Agents

Русинов

Сапожникова

Bliznik

et al. 2017

Archiv der Pharmazie

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Inhibition of the dipeptidyl peptidase-4 (DPP4) enzyme activity and prevention of advanced glycation end (AGE) products formation represents a reliable approach to achieve control over hyperglycemia and the associated pathogenesis of diabetic vascular complications. In the frames of this research study, several triazolo- and pyrazolotriazines were synthesized and evaluated as inhibitors of AGE products formation, DPP4, glycogen phosphorylase and α-glucosidase activities, as well as AGE cross-link breakers. From the two considered classes of heterocyclic compounds, the pyrazolotriazines showed the highest potency as antiglycating agents and DPP4 inhibitors. Structure-activity relationships (SAR) for these compounds, which can be considered as potential drugs for the treatment of type 2 diabetes, were evaluated.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1‐c][1,2,4]‐triazines and Pyrazolo[5,1‐c][1,2,4]triazines as Potential Antidiabetic Agents

Русинов

Сапожникова

Bliznik

et al. 2017

Archiv der Pharmazie

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“…Benzimidazole is an important structural moiety which is present in many natural and synthetic compounds with a variety of interesting biological activities [1], such as anticancer [2], antiarrhythmic [3], antihistaminic [4], antiulcerative [5], antihypertensives, antiviral, antitumor [1], antibacterial, antifungals [6], anti-inflammatory [7], anticonvulsant, antidiabetic properties [8], and antidepressant [9]. The first benzimidazole was described by Hobrecker in 1872, who obtained 2,5 (or 2,6)-dimethylbenzimidazole by the reduction of 2-nitro-4-methylacetanilide [10].…”

Section: Introductionmentioning

confidence: 99%

Copper-incorporated fluorapatite encapsulated iron oxide nanocatalyst for synthesis of benzimidazoles

2017

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c-Fe 2 O 3 @CuFAp nanocatalyst was synthesized and characterized by several methods including XRD, SEM, TEM, ICP, and FT-IR analyses. The c-Fe 2 O 3 @-CuFAp has been used as an efficient recyclable magnetic catalyst for synthesis of benzimidazoles. The c-Fe 2 O 3 @-CuFAp was conveniently separated from the reaction mixture by an external magnet, and could be reused at least 12 times without any considerable change in catalytic activity. Graphical abstract

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Recent Trends in the Synthesis of Benzimidazoles From o‐Phenylenediamine via Nanoparticles and Green Strategies Using Transition Metal Catalysts

Singhal

Khanna

Panda

et al. 2019

Journal of Heterocyclic Chem

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Benzimidazole is a heterocyclic moiety of immense importance as it acts as a primary “biolinker” in diverse synthetic routes to obtain bioactive compounds. Substituted benzimidazoles are known to possess a varied range of pharmacological applications, namely, anti‐cancer, anti‐diabetic, anti‐inflammatory, and antiviral like anti‐HIV and anti‐fungal. A number of reviews covering the important aspects of benzimidazoles such as pharmacological activities, SAR studies, and well‐known methods of synthesis have appeared in the literature. However, green synthetic methods particularly using transition metal (TM) catalysts and their nanoparticles, although being more viable and extensively applied by researchers in the present scenario, have not been exclusively and expansively reviewed. Besides this, the vital precursors required for knitting the skeleton of benzimidazole are mainly o‐aryldiamines. The conventional synthesis generally involved the condensation of these diamines with carbonyl/carboxylic acid derivatives either via high temperature heating or via adding strong acids, mostly resulting in poor yields or mixtures. However, recent trends are replacing these conditions by mild and green conditions through TM catalysts. Therefore, the current review emphasizes on the recent trends adopted in the synthesis of benzimidazoles using condensation reaction of o‐phenylenediamines and various aldehydes/ester/amide/alcohols with TM in a catalytic role in nanoform and under environmentally benign green conditions.

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Hypoglycemic Potential of Benzimidazole Derivatives

Cited by 8 publications

References 29 publications

Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1‐c][1,2,4]‐triazines and Pyrazolo[5,1‐c][1,2,4]triazines as Potential Antidiabetic Agents

Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1‐c][1,2,4]‐triazines and Pyrazolo[5,1‐c][1,2,4]triazines as Potential Antidiabetic Agents

Copper-incorporated fluorapatite encapsulated iron oxide nanocatalyst for synthesis of benzimidazoles

Recent Trends in the Synthesis of Benzimidazoles From o‐Phenylenediamine via Nanoparticles and Green Strategies Using Transition Metal Catalysts

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