Hypoglycemic episodes are associated with inflammatory status in patients with type 1 diabetes mellitus

Impaired awareness of hypoglycaemia: A new risk factor for adverse pregnancy outcomes in type 1 diabetes

“…Chronic inflammation induces a decrease in HDL‐c and, in parallel, increases the synthesis and accumulation of triglyceride‐rich lipoproteins typical of the insulin‐resistance syndrome . In a non‐pregnant population, repeated hypoglycaemic events in patients with T1D have been associated with increased inflammatory and endothelial dysfunction markers regardless of HbA 1c . Although no differences have been reported in the conventional lipid profile in non‐pregnant patients with T1D and repeated hypoglycaemia in previous studies, advanced lipoprotein subclasses analysis might be able to determine possible differences, as has been noted in the improvement of metabolic control in the Diabetes Control and Complications Trial .…”

“…20 In a non-pregnant population, repeated hypoglycaemic events in patients with T1D have been associated with increased inflammatory and endothelial dysfunction markers regardless of HbA 1c . 4,10,21 Although no differences have been reported in the conventional lipid profile in non-pregnant patients with T1D and repeated hypoglycaemia in previous studies, advanced lipoprotein subclasses analysis might be able to determine possible differences, as has been noted in the improvement of metabolic control in the Diabetes Control and Complications Trial. 22 Furthermore, mild inflammation in women with IAH could trigger greater insulin resistance during pregnancy, thereby enhancing alterations in lipid profile.…”

“…Repeated non‐SH and impaired awareness of hypoglycaemia (IAH) in patients with T1D have been associated with chronic inflammation regardless of good metabolic control . The effect of this mild inflammation during pregnancy in a high‐risk population has not yet been studied.…”

“…[7][8][9] Repeated non-SH and impaired awareness of hypoglycaemia (IAH) in patients with T1D have been associated with chronic inflammation regardless of good metabolic control. 4,10 The effect of this mild inflammation during pregnancy in a high-risk population has not yet been studied. Against this background, the aims of our study were to evaluate if IAH in pregnant women with T1D worsens metabolic control and to study its impact on maternal and neonatal outcomes.…”

IL-6 and type 1 diabetes mellitus: T cell responses and increase in IL-6 receptor surface expression

“…Kiec-Wilk et al (16) in a multiple linear regression analysis observed that the number of hypoglycemic episodes per 7 days was an independent predictor of high levels of IL-6. In another study, Gogitidze Joy et al (17) evaluated T1D patients during either a 2-h hyperinsulinemic euglycemic or hypoglycemic clamp, where it was observed that IL-6 plasma levels were significantly increased during the 2 h of hyperinsulinemic hypoglycemia as compared with euglycemia subjects.…”