Hypoglycemic effects of Teucrium polium

Gharaibeh, Munir; Elayan, Hamzeh; Salhab, Abdulazim S.

doi:10.1016/0378-8741(88)90139-0

Cited by 118 publications

(81 citation statements)

References 11 publications

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“…Recently, researchers have shown that herbal remedies can help improve diabetic complications (26). There are several well-known plants with hypoglycemic effects, such as Teucrium polium, Smallanthus sonchifolius (yacon), Psacalium peltatum, and Cucurbita ficifolia (27)(28)(29). Among these plants, Stevia rebaudiana Bertoni is a natural sweetener for individuals with a carbohydrate-controlled diet.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Aquatic Extract of Stevia on the Serum Level of Interleukin-6 in Streptozotocin-Nicotinamide Induced Diabetic Rats

et al. 2017

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Background: Diabetes, as a common chronic disorder, is the seventh leading cause of death in the world. This disorder is classified into two major types: type I and type II diabetes mellitus. Recently, researchers have identified a higher level of inflammatory cytokines in patients with type II diabetes, compared to the normal population. Today, plant-based therapies, given their anti-diabetic properties, have attracted the researchers' attention. One of the medicinal plants with anti-diabetic effects is Stevia rebaudiana Bertoni. Various hypotheses have been proposed to explain how stevioside, as a derivative of Stevia rebaudiana, can cause such a significant decline in blood glucose level. To the best of our knowledge, the exact anti-inflammatory and immunomodulatory effects of the aquatic extract of stevia are not fully understood. Therefore, the current research aimed to evaluate whether stevia can improve the interleukin-6 (IL-6) level in streptozotocin-nicotinamide-induced diabetic rats. Methods:In the present study, a cohort of rats was divided into five groups, each containing 11 rats: (1) normoglycemic group, receiving 1 mL of water; (2) diabetic control group, receiving 1 mL of water; (3) and (4) diabetic groups treated with the aquatic extracts of stevia (400 mg/kg) and metformin (500 mg/kg), respectively; and (5) healthy group treated with the aquatic extract of stevia (400 mg/kg). At the end of the experiment, the rats were sacrificed and blood samples were collected from the heart for evaluating serum IL-6 changes. Statistical analysis was performed, using one-way analysis of variance (ANOVA), followed by the least significant difference (LSD) post-hoc multiple comparison test. Results:The present results showed that IL-6 (P = 0.001) and fasting blood sugar (FBS) (P < 0.001) levels significantly increased in all diabetic groups, compared to healthy rats. Surprisingly, treatment with stevia could significantly reduce FBS (P < 0.001), as well as IL-6 level (P = 0.001) in comparison with the diabetic group.Conclusions: Based on the findings, inflammation can be ameliorated with the whole aquatic extract of stevia, as an anti-diabetic compound. Therefore, by considering IL-6 level as an indicator of insulin resistance, stevia can lead to a decline in IL-6 level and thereby reduce insulin resistance in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Effect of the Aquatic Extract of Stevia on the Serum Level of Interleukin-6 in Streptozotocin-Nicotinamide Induced Diabetic Rats

et al. 2017

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“…Ces espèces ont été utilisées depuis des siècles en médecine traditionnelle comme cholagogues, antispasmodiques, diurétiques, antidiabétiques, antiphlogistiques, antirhumatismales, antiseptiques, anthelminthiques et carminatives (Gharaibeh et al, 1988(Gharaibeh et al, , 1989.…”

Section: Introductionunclassified

Morphologie du trichome desTeucriumdu Liban

Beyrouthy¹,

Arnold²,

Delelis-Dusollier³

et al. 2008

Acta Botanica Gallica

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and T. polium L.) ont été réalisées dans le cadre d'une étude sur le genre Teucrium. Vingt types de poils (treize tecteurs, sept glanduleux) sont dénombrés sur les six taxons étudiés. Treize types caractérisent une seule espèce, alors que trois poils sont cantonnés à deux espèces. Seulement quatre types sont communs à toutes les espèces. Cependant parmi ces vingt trichomes, douze types de poils tecteurs sont caractéristiques d'une ou deux espèces pour seulement quatre poils glanduleux. Les poils tecteurs sont plus importants que les poils glanduleux en ce qui concerne la séparation entre les espèces de Teucrium. Cette étude montre aussi que les corolles ont le plus grand nombre (cinq sur vingt) de types de poils caractéristiques, suivies par les calices, les feuilles avec deux sur vingt et un seul poil est typique à la fois des feuilles et tiges. Davis, T. orientale L. var. orientale and T. polium L.) distributed in Lebanon wascarried out as part of the taxonomical study of the genus Teucrium. Twenty different types of trichome (13 non-glandular, 7 glandular) were found on the six studied species. Thirteen types were characteristic for one species and three types were characteristic of two species. Only four types were found on the six studied species. On the twenty different types of trichome, twelve non-glandular hairs and only four glandular hairs were characteristic of one or two species. Those results indicate that non-glandular hairs are more important than glandular hairs concerning the separation between Teucrium species. This study also show that the corolla have the most important number of typical trichome (5/20) followed by leaves and calyxes (2/20) each and only one trichome is typical to both leaves and stems.

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“…5%-phenyl-95%-dimethylpolysiloxane was purchased from Varian Inc. (USA), while formalin, ethanol, acetic acid, HNO 3 and distilled water were purchased from Kemika (Croatia). All chemicals and reagents were of analytical grade and double distilled water was used throughout the study.…”

Section: Chemicals and Microorganismsmentioning

confidence: 99%

Chemical traits and antimicrobial activity of endemic Teucrium arduini L. from Mt Biokovo (Croatia)

Kremer

Müller²,

Dunkić

et al. 2012

Open Life Sciences

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Chemical composition of the essential oil (analysed by GC-FID and GC-MS), the content of macroelements and trace elements (analysed by ICP-AES), and antimicrobial activities were investigated in Teucrium arduini L. from Mt Biokovo (Croatia). Additionally, a study on the types and distribution of glandular trichomes which produce essential oils was investigated. The oil was characterized by a high concentration of sesquiterpene hydrocarbons (68.5%) of which β-caryophyllene (32.9%) and germacrene D (16.4%) being the major compounds. Among the macroelements, the content of calcium was the highest (9772 mg/kg), while the content of sodium was the smallest (117.74 mg/kg). Among the micronutrients, the most represented element was iron (72.07 mg/kg). The content of each investigated toxic metal (As, Hg, Pb, Cd and Cr) was below permissible levels. The essential oils showed antimicrobial activity against bacterial species tested, with MIC values ranging from 6.25 mg/mL to 37.50 mg/mL. Fungal species were susceptible with MIC values from 7.81 mg/mL and 25.00 mg/mL.

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Hypoglycemic effects of Teucrium polium

Cited by 118 publications

References 11 publications

Effect of the Aquatic Extract of Stevia on the Serum Level of Interleukin-6 in Streptozotocin-Nicotinamide Induced Diabetic Rats

Effect of the Aquatic Extract of Stevia on the Serum Level of Interleukin-6 in Streptozotocin-Nicotinamide Induced Diabetic Rats

Morphologie du trichome desTeucriumdu Liban

Chemical traits and antimicrobial activity of endemic Teucrium arduini L. from Mt Biokovo (Croatia)

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