Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model

Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice

“…Due to insufficient insulin secretion or resistance, blood glucose rises abnormally. 33 As shown in Fig. 1B, the FBG value of HSHF-diet and STZ-induced mice (HFD, MH, SVM-L, and SVM-H group) was significantly ( p < 0.05) higher than that of NFD group mice at the 0 th week.…”

Structural changes and molecular mechanism study on the inhibitory activity of epigallocatechin against α-glucosidase and α-amylase

“…Additionally, EGC has the advantages of being safe and having smaller side effects. It is more suitable for long-term blood sugar drugs ( 5 , 8 ) and long-term control of blood glucose. These results suggest that EGC is a potent alternative α-glucosidase and α-amylase inhibitor with potential value in the production of hypoglycemic drugs and functional foods.…”

“…Although these drugs can effectively control PBG increases, their long-term use causes a series of side effects, such as nausea, vomiting, flatulence, diarrhea, and gradually increased drug resistance (6). Increasing evidence shows that many tea extracts inhibit α-glucosidase and α-amylase, thereby showing hypoglycemic activity (7)(8)(9). Therefore, finding safe and effective α-glucosidase or α-amylase inhibitors from natural plant resources is a key task in the fields of food, biology, and medicine.…”

Synergistic effects of l-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation

“…Then, western blotting was performed as previously reported. 22 The following antibodies were used: Lyn (60211-1-Ig, Proteintech, 1 : 1000, 56 kDa), p-Lyn (ab278639, Abcam, 0.01 μg mL −1 , 59 kDa), Syk (14858-1-AP, Proteintech, 1 : 1000, 65–72 kDa), p-Syk (ab278675, Abcam, 1 μg mL −1 , 60–80 kDa), AKT (10176-2-AP, Proteintech, 1 : 2000, 56–62 kDa), p-AKT (66444-1-Ig, Proteintech, 1 : 5000, 60–62 kDa), PI3K (20584-1-AP, Proteintech, 1 : 500, 110–130 kDa), p-PI3K (20890-1-Ig), PLC-γ (ab302940, Abcam, 1 : 1000, 150 kDa), p-PLC-γ (ab109501, Abcam, 1 : 1000, 149 kDa), Btk (ab208937, Abcam, 1 : 1000, 76 kDa), and p-Btk (ab40770, Abcam, 1 : 2000, 74 kDa), β-actin (66009-1-Ig, Proteintech, 1 : 5000, 42 kDa).…”