Hypoglycemic effects of a sesquiterpene glycoside isolated from leaves of loquat (Eriobotrya japonica (Thunb.) Lindl.)

Chen, J.; Li, W.L.; Wu, Julan; Ren, Bingru; Zhang, H.Q.

doi:10.1016/j.phymed.2006.12.014

Cited by 87 publications

(46 citation statements)

References 9 publications

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“…The occurrence of polyphenolic constituents in the leaves and their cytotoxicity against human oral tumor cell lines were also reported (Ito et al, 2000). Current other studies have shown that the sesquiterpene glycoside, nerolidol-3-O-α-lrhamnopyranosyl(1→4)-α-l-rhamnopyranosyl(1→2)-[α-l-rhamnopyranosyl(1→6)]-β-D-glucopyranoside from the leaves of E. japonica produces a signifi cant antihyperglycemic effect when administered orally to alloxan-diabetic mice (Chen et al, 2008). The reported bioactive components of loquat include fl avonoids (Louati et al, 2003), phenolics (Ding et al, 2001), amygdalin (Zhuang, 2002), triterpenic acids (Liang et al, 1990) and carotenoids (Godoy and Amaya, 1995).…”

Section: Introductionmentioning

confidence: 87%

Eriobotrya japonica improves hyperlipidemia and reverses insulin resistance in high‐fat‐fed mice

Shih

Lin

2010

Phytotherapy Research

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The effect of Eriobotrya japonica Lindl. (loquat) on insulin resistance was examined in mice fed a high-fat (HF) diet. First, the mice were divided randomly into two groups: the control (CON) group was fed a low-fat diet, whereas the experimental group was fed with a 45% HF diet for 10 weeks. After 6 weeks of induction, the HF group was subdivided into five groups and was given orally loquat or not for 4 weeks afterward. It was demonstrated that loquat was effective in ameliorating the HF diet-induced hyperglycemia, hyperleptinemia, hyperinsulinemia and hypertriglyceridemia, as well as in decreasing the levels of free fatty acid (FFA), but increasing the adipose PPARγ (peroxisomal proliferator-activated receptor γ) and hepatic PPARα mRNA levels. Loquat significantly decreased the body weight gain, weights of white adipose tissue and visceral fat accompanying the suppressed leptin mRNA levels. Loquat not only suppressed the hepatic mRNA levels of enzymes involved in fatty acid and triacylglycerol synthesis and lowered the sterol regulatory element binding protein-1c (SREBP-1c) mRNA level, but also affected fatty acid oxidation enzyme levels. These regulations may contribute to triacylglycerol accumulation in white adipose tissue. The findings provide a nutritional basis for the use of loquat as a functional food factor that may have benefits for the prevention of hyperlipidemia and diabetes.

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Section: Introductionmentioning

confidence: 87%

Eriobotrya japonica improves hyperlipidemia and reverses insulin resistance in high‐fat‐fed mice

Shih

Lin

2010

Phytotherapy Research

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“…비파 잎에는 다양한 terpenoid (Nazato et al 1984)와 플라보노이드 (Jung et al 1999 (Nazato et al 1994;Jung et al 1994;Taniguchi et al 2002). 이 밖에도 비파 잎, 씨 또는 과육에 다량 함유되어 있는 유용한 화합물들의 항산화효과 (Jung et al 1994;Koba et al 2007;Lee et al 2009), 항 당뇨효과 (Chen et al 2008), 항염증 및 항암효과 Banno et al 2005;Huang et al 2007), 항바이러스효과 (De Tommasi et al 1992 Seedless fruit.…”

Section: 서론unclassified

Effects of Loquat (Eriobotrya japonica Lindl.) Ethanol Extracts of Different Aerial Parts on Antioxidant Activity and Antiproliferation of Human Cancer Cells

Lee¹,

Kim²,

Lee³

et al. 2016

KJCLS

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The current study was carried out to determine the effects of the seed, flesh (seedless fruit), and leaf of loquat (Eriobotrya japonica Lindle.) on antioxidative activity and anti-proliferation in human cancer cells. Total polyphenol contents of loquat seed, flesh, and leaf ethanol extracts were found to be 17.77, 32.32, and 28.08 mg/g, respectively. Also, total flavonoid contents of loquat seed, flesh, and leaf ethanol extracts were found to be 18.77, 28.73, and 21.35 mg/g, respectively. The IC 50 values of DPPH hydroxyl scavenging of loquat seed, flesh, and leaf ethanol extracts were 0.049, 0.063, and 0.042 mg/mL, respectively. Antioxidative indexes of loquat leaf and seed ethanol extracts was highly and it was similar to the BHA and BHT. The antioxidative activities in loquat seed and leaf ethanol extracts were higher in loquat flesh. The antiproliferation effect of loquat seed and leaf ethanol extracts on liver cancer cell line (H460), stomach cancer cell line (AGS) and lung cancer cell line (A549) showed higher values compared with the flesh ethanol extracts. These results indicate that loquat ethanol extracts may play a positive role in antioxidative properties and cancer prevention.

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“…비파 잎의 주요 성분은 sesquiterpene 배당체로 ferulic acid, nerolidol 등을 함유하고 있으며 (Lee et al 2004), triterpene 계열의 화합물로는 ursolic acid, oleanolic acid, maslinic acid, tormentic acid, hyptadienic acid 등을 함유하고 있는 것으로 보고 (Shimizu et al 1996; Taniguchi et al 2002)되었다. 이와 같이 다양한 생리 활성 성분으로 인해 비파 잎은 항당뇨 (Shimizu et al 1986;Chen et al 2008), 항산화 (Jung et al 1999), 항염증 (Huang et al 2007;Matalka et al 2007), 항돌 연변이 및 항암활성 ) 효능이 있는 것으 로 보고되었다. 비파 씨는 열매 속에 둥근 형태로 갈 색을 띄고 있으며 (Yook 1986;Cho et al 1991 …”

Section: 지방세포는 배양 중에 다양한 생리활성물질을 함유unclassified

Effects of Loquat(Eriobotrya japonica Lindl.) Extracts in Different Aerial Components on Differentiation of 3T3-L1 Cells and Pig Preadipocytes

Lee¹,

Lee²

2016

KJCLS

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The current study was undertaken to determine the effects of the ethanol extracts of loquat (Eriobotrya japonica Lindl.) seeds, flesh or leaves on the differentiation of 3T3-L1 cells and male pig preadipocytes. The cell number was measured with the MTT assay after trypsin digestion. The cell differentiation was determined by measuring the glycerol-3-phosphate dehydrogenase (GPDH) activity and triglyceride(TG) content. No cytotoxicity was observed from the loquat flesh and leaf ethanol extracts at concentrations of 5, 10, 25, 50, 100 or 200 μg/mL in 3T3-L1 cells and pig preadipocytes. However, the cell viability of neither cell line were affected by up 50 μg/mL of loquat seed ethanol extract. Treatment with the loquat seed and leaf ethanol extracts significantly suppressed the terminal differentiation of both cell lines in a dose-dependent manner, as confirmed by the decrease in the glycerol-3-phosphate dehydrogenase(GPDH) activity and TG content. Treatment with the loquat seed and leaf ethanol extracts inhibited the GPDH activity and reduced the TG content of both cell types more effectively than that with the loquat flesh ethanol extract. The most potent anti-adipogenic effect was obtained in the case of the ethanol extract of loquat seeds.

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Hypoglycemic effects of a sesquiterpene glycoside isolated from leaves of loquat (Eriobotrya japonica (Thunb.) Lindl.)

Cited by 87 publications

References 9 publications

Eriobotrya japonica improves hyperlipidemia and reverses insulin resistance in high‐fat‐fed mice

Eriobotrya japonica improves hyperlipidemia and reverses insulin resistance in high‐fat‐fed mice

Effects of Loquat (Eriobotrya japonica Lindl.) Ethanol Extracts of Different Aerial Parts on Antioxidant Activity and Antiproliferation of Human Cancer Cells

Effects of Loquat(Eriobotrya japonica Lindl.) Extracts in Different Aerial Components on Differentiation of 3T3-L1 Cells and Pig Preadipocytes

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