Hypoglycemic effect of poly-herbal combination in streptozotocin-induced diabetic rats

Kurian, Gino A.

doi:10.3329/bjp.v11i2.24855

Cited by 3 publications

(1 citation statement)

References 30 publications

(18 reference statements)

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“…The antidiabetic activity of combination of Salacia oblonga, Tinospora cordifolia, Emblica o cinalis, Curcuma longa and Gymnema sylvestre was determined in streptozotocin (55 mg/kg, i.p. )-induced diabetic rats, at a dose of 100 mg/kg [6].…”

Section: Introductionmentioning

confidence: 99%

Biotransformation in Combination of Traditional Medicinal Plants: The Effect of Wickerhamomyces Anomalus on the Antidiabetic Potential and Metabolite Profiling

Gaur¹,

Shanmugam²

2020

Preprint

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Background: Biochemical transformation is a green and efficient strategy that can be of help in case of potentiation of herbal treatments. Diabetes requires daily therapeutic interventions and the use of herbals can be safe and effective alternatives however higher doses of herbs can cause much inconvenience. The potentiation of traditional medicinal plants based polyherbal combinations to reduce the dosage can be an attractive approach. Methods: The present study explored the biochemical transformation of a polyherbal extract derived from Syzygium cumini seed, Mangifera indica seed kernel, Momordica charantia fruit and Gymnema sylvestre leaf using W.anomalus. The polyherbal extract was chromatographed and evaluated for antidiabetic potential, Pre and Post fermentation. Also, the fermentation kinetics was assessed as W. anomalus can produce ethanol which can be self-limiting. Results: The extract produced no behavioral or physical changes in animals, confirming the safety in acute toxic exposure. The chromatographic analysis showed good presence of Hesperidin, Mangiferin and Corilagin in non-fermented extract which was significantly reduced and content of Apigenin, Luteolin, Quercetin, kaempferol and Isorhamnetin were increased after fermentation. Conclusions: The polyherbal extract showed good antidiabetic activity however fermented polyherbal extract showed a similar effect at half the dosage. The effects are also corroborated by histological studies.

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Section: Introductionmentioning

confidence: 99%

Biotransformation in Combination of Traditional Medicinal Plants: The Effect of Wickerhamomyces Anomalus on the Antidiabetic Potential and Metabolite Profiling

Gaur¹,

Shanmugam²

2020

Preprint

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Antidiabetic potential and metabolite profiling of biotransformed polyherbal extract using Wickerhamomyces anomalus strain(MTCC-4133)

Gaur¹,

Kumar²,

Puri³

2021

Process Biochemistry

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Can Polyherbal Medicine be used for the Treatment of Diabetes? - A Review of Historical Classics, Research Evidence and Current Prevention Programs

Brahma

Goyal

Prakash

et al. 2024

CDR

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Diabetes mellitus (DM), a chronic medical condition, has attained a global pandemic status over the last few decades affecting millions of people. Despite a variety of synthetic drugs available in the market, the use of herbal medicines for managing diabetes is gaining importance because of being comparatively safer. This article reviews the result of a substantial literature search on polyherbal formulations (PHFs) developed and evaluated with potential for DM. The accumulated data in the literature allowed us to enlist 83PHFs consisting of different parts of 147 plant species belonging to 58 botanical families. The documented plant species are laden with bioactive components with anti-diabetic properties and thus draw attention. The most favoured ingredient for PHFs was leaves of Gymnema sylvestre and seeds of Trigonellafoenum-graecum used in 29 and 27 formulations, respectively. Apart from herbs, shilajit (exudates from high mountain rocks) formed an important component of 9 PHFs, whereas calcined Mytilus margaritiferus and goat pancreas were used in Dolabi, the most commonly used tablet form of PHF in Indian markets. The healing properties of PHFs against diabetes have been examined in both pre-clinical studies and clinical trials. However, the mechanism(s) of action of PHFs are still unclear and considered the pitfalls inherent in understanding the benefits of PHFs. From the information available based on experimental systems, it could be concluded that plant-derived medicines will have a considerable role to play in the control of diabetes provided the challenges related to their bioavailability, bioefficacy, optimal dose, lack of characterization, ambiguous mechanism of action, and clinical efficiency are addressed.

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Hypoglycemic effect of poly-herbal combination in streptozotocin-induced diabetic rats

Cited by 3 publications

References 30 publications

Biotransformation in Combination of Traditional Medicinal Plants: The Effect of Wickerhamomyces Anomalus on the Antidiabetic Potential and Metabolite Profiling

Biotransformation in Combination of Traditional Medicinal Plants: The Effect of Wickerhamomyces Anomalus on the Antidiabetic Potential and Metabolite Profiling

Antidiabetic potential and metabolite profiling of biotransformed polyherbal extract using Wickerhamomyces anomalus strain(MTCC-4133)

Can Polyherbal Medicine be used for the Treatment of Diabetes? - A Review of Historical Classics, Research Evidence and Current Prevention Programs

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