Hypoglycemic Effect of Padina arborescens Extract in Streptozotocin-induced Diabetic Mice

Abstract

This study investigated the hypoglycemic effect of the Padina arborescens extract in STZ-induced diabetic mice. Freeze-dried Padina arborescens were extracted with 80% methanol and concentrated for use in this study. The hypoglycemic effect was determined by inhibitory activities against α-glucosidase and α-amylase as well as the alleviation of postprandial blood glucose level. Padina arborescens extracts showed higher inhibitory activities than acarbose, a positive control against α-glucosidase and α-amylase. The IC50 values of Padina arborescens extracts against α-glucosidase and α-amylase were 0.26 and 0.23 mg/mL, respectively, which evidenced as more effective than observed with acarbose. The increase of postprandial blood glucose levels were significantly suppressed in the Padina arborescens extract administered group than the control group in the streptozotocin induced diabetic mice. Furthermore, the area under the curve (AUC) was significantly lowered via Padina arborescens extract administration in diabetic mice (p < 0.05). These results indicated that the Padina arborescens extract might be used as an inhibitor of α-glucosidase and α-amylase and delay absorption of dietary carbohydrates.

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“…There was an improvement in S. asperum extract and glipizide treated rats on liver protein levels, which might be due to the marked changes in circulating amino acid level, hepatic amino acid uptake and muscle output of amino acid concentrations 19 . The increased hepatic glucose output in diabetes may be derived from glucogenesis 20,21 .…”

“…Normalization of increased blood glucose by S. asperum extract suggests that it may enhance glucose transport across the cell membranes and stimulate glycogen synthesis or enhance glycolysis. Similarly, anti-hyperglycemic effects have been observed by the restoration of blood glucose level to normal in diabetic rats through different solvent extracts of brown alga Cystoseira moniliformis, 16 Padina arborescens 19 and Lobophora variegata 13 .…”

Effect of Antihipoglycemic Sechium edule Jacq. Swartz. Etanol Extract on Histopathologic Changes in Hyperglycemic Mus musculus L.

“…KGD male white mouse called DM in this study was ≥250 mg/ dl. Studyers used STZ at a dose of 60 mg/ kgBW, administered intraperitoneally (Park and Han, 2012) on day 4 of the KGD measurements shown in Table 2. Description: U1 (Repeat 1), U2 (Repeat 2) U3 (Repeat 3), U4 (Repeat 4), U5 (Repeat 5) U6 (Repeat 6), U7 (Repeat 7).…”

Padina arborescensextract protects high glucose-induced apoptosis in pancreatic β cells by reducing oxidative stress

“…In previous studies, we evaluated the antioxidant properties of Padina arborescens extract (PAE) [ 8 ]. We also evaluated the effects of PAE on postprandial hyperglycemia by in vivo tests and showed the prominent effect of PAE in both streptozotocin-induced diabetic mice and normal mice [ 9 ]. However, there is currently no evidence of a direct involvement of PAE on pancreatic β cell functions and diabetes-related survival.…”