Hypoglycemic effect of inulin combined with ganoderma lucidum polysaccharides in T2DM rats

Liu, Yaping; Li, Yumeng; Zhang, Wenlingzi; Sun, Mingzhe; Zhang, Zesheng

doi:10.1016/j.jff.2019.02.036

Cited by 62 publications

(28 citation statements)

References 34 publications

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“…In Table 3, the weight gain of DM mice was significantly reduced compared to the normal mice, which were similar to the symptoms of polyphagia and loss of body weight in diabetic patients (Liu et al., 2019b). After dietary treatment, the emaciation of mice in each dose group was improved compared with that in the DC group, but the difference was not significant, and it could not reach the level of NC group ( P <0.05).…”

Section: Resultssupporting

confidence: 62%

Modification of pea dietary fiber by ultrafine grinding and hypoglycemic effect in diabetes mellitus mice

Wang

Chen

Dong

et al. 2021

Journal of Food Science

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This study was designed to investigate the effects of ultrafine grinding on the physicochemical properties of pea dietary fiber (PDF) and the hypoglycemic effect of ultrafine grinding dietary fiber on diabetes mellitus (DM). So, the PDF was treated by ultrafine grinding technology, and its microstructure and physicochemical properties were determined. Then, the DM model was established, and the 4-week ultrafine grinded pea dietary fiber (UGPDF) diet intervention was conducted by using gavage and feeding. During this period, the blood glucose and body weight of the mice were measured, and an oral glucose tolerance test was measured on the last day. The biochemical blood indexes of the mice were determined, and the pancreas was stained with HE after dissecting. The results showed that after ultrafine grinding, the structure fragmentation, specific surface area increased, and UGPDF showed higher swelling ability as well as water and oil holding capacities. Simultaneously, UGPDF had a significant effect on reducing blood glucose and glycosylated hemoglobin in DM mice, improving the wasting state of mice and increasing the tolerance to glucose. Further, the results of the HE section showed that the pancreatic islet cells gradually returned to normal regular morphology. In biochemical blood indicators, UGPDF reduced TC and TG levels in the blood. This study provided a specific data basis for the following research on the hypoglycemic mechanism, and broadens the application field of PDF.Practical Application: The physicochemical properties of pea dietary fiber were improved by ultrafine grinding technology. Because of this, the application of pea dietary fiber in the field of hypoglycemic had a better effect, laying a foundation for the next research on hypoglycemic mechanism.

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Section: Resultssupporting

confidence: 62%

Modification of pea dietary fiber by ultrafine grinding and hypoglycemic effect in diabetes mellitus mice

Wang

Chen

Dong

et al. 2021

Journal of Food Science

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“…Little data is available on the possible synergistic effects of G. lucidum polysaccharides. Recently research [47] was carried out on rats with type 2 diabetes induced by HFD / STZ. Oral administration of a combination of G. lucidum inulin and polysaccharides significantly improved body weight and normalized food intake by increasing carbohydrate utilization.…”

Section: Polysaccharides Isolated From Ganoderma Speciesmentioning

confidence: 99%

“…A reduction in glycogen content was also observed in diabetic rats, which is important because the amount of glycogen in the liver and skeletal muscle is an indirect reflection of insulin activity. The results obtained suggest that the combination of inulin with G. lucidum polysaccharides may regulate glucose levels by increasing glycogenesis [47].…”

Section: Polysaccharides Isolated From Ganoderma Speciesmentioning

confidence: 99%

“…On the other hand, it can also effectively modulate glycogen synthesis, reducing glycogen synthase kinase 3β (GSK3β) phosphorylation. The combination of G. lucidum polysaccharides with inulin increased gene expression and synthesis of proteins of the PI3K/Akt pathway and increased Akt phosphorylation in diabetic rats compared to the inulin group [47].…”

Section: Polysaccharides Isolated From Ganoderma Speciesmentioning

confidence: 99%

“…Due to the satisfactory effect and medical potential of Ganoderma , they were used in clinical studies for various indications, not only diabetes [6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66].…”

Section: Summarized Treatment Mechanism By Ganodermamentioning

confidence: 99%

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Mushrooms of the Genus Ganoderma Used to Treat Diabetes and Insulin Resistance

et al. 2019

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Pharmacotherapy using natural substances can be currently regarded as a very promising future alternative to conventional therapy of diabetes mellitus, especially in the case of chronic disease when the body is no longer able to produce adequate insulin or when it cannot use the produced insulin effectively. This minireview summarizes the perspectives, recent advances, and major challenges of medicinal mushrooms from Ganoderma genus with reference to their antidiabetic activity. The most active ingredients of those mushrooms are polysaccharides and triterpenoids. We hope this review can offer some theoretical basis and inspiration for the mechanism study of the bioactivity of those compounds.

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Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties

Ahmad

Riaz

Khan

et al. 2021

Phytotherapy Research

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Reishi owes an exceptional value in nutritional, cosmeceutical, and medical treatments; however, none of the studies has provided its future-driven critical assessment. This study documents an up-to-date review (2015-2020, wherever applicable) and provide valuable insights (preclinical and clinical evidence-based) with comprehensive and critical assessments. Various databases 'Google scholar', 'Web of Science', 'ScienceDirect', 'PubMed', 'Springer Link', books, theses

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Hypoglycemic effect of inulin combined with ganoderma lucidum polysaccharides in T2DM rats

Cited by 62 publications

References 34 publications

Modification of pea dietary fiber by ultrafine grinding and hypoglycemic effect in diabetes mellitus mice

Modification of pea dietary fiber by ultrafine grinding and hypoglycemic effect in diabetes mellitus mice

Mushrooms of the Genus Ganoderma Used to Treat Diabetes and Insulin Resistance

Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties

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