Hypoglycemic Effect of Ethanolic Extract of Musa sapientum on Alloxan-Induced Diabetes Mellitus in Rats and Its Relation with Antioxidant Potential

Dhanabal, S P; Sureshkumar, Muthusamy; Ramanathan, Meena; Suresh, Bhorjraj

doi:10.1300/j157v05n02_02

Cited by 16 publications

(22 citation statements)

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“…However, there was a significant difference in body weight gain between negative control and positive control groups. Dhanabal et al (2005) proved that banana peels supplemented diet caused varying percentage weight gains in all groups, which were not statistically significant when compared to the control. However the percentage weight gain reduced after the induction of hepatotoxicity.…”

Section: Chemical Analysismentioning

confidence: 86%

The effect of banana peels supplemented diet on acute liver failure rats

Mosa

Khalil

2015

Annals of Agricultural Sciences

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Peel of vegetables and fruits are of the most important part that helps in protecting the body from diseases, getting rid of the free radicals, as they contain vitamins and minerals which are antioxidant, in addition to phenols. Previous studies have proved the existence of vitamin C, E, and B6 in banana peels, especially vitamin C that can act as an antioxidant.The present study was performed to examine the effect of fresh and dried banana peels consumption on liver function (albumin, GPT, GOT, LDH, GGT and ALP) and lipid profiles cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) on acute liver failure rats induced by carbon tetrachloride. The chemical constituents, vitamins, minerals and fiber were determined for the tested fresh and dried banana peels.This work was carried out on 40 adult male white albino rats randomly classified into eight groups (each of 5 rats). The first group was fed on basal diet as a ''negative control". The other seven groups were injected by carbon tetrachloride to induce liver failure. The second group fed on basal diet as acute liver failure rat's untreated ''positive control", the third into five groups fed on basal diet containing 5%, 10% and 15% fresh banana peels while the six into eight groups fed on basal diet containing of 5%, 10% and 15% dried banana peels for a period of four consecutive weeks.Results revealed that all acute liver failure groups administrated with different levels of fresh banana peels (5%, 10% and 15%) had significant decrease in liver function, total cholesterol, triglycerides, LDL-c and VLDL-c cholesterol comparing with the positive control group. On the other hand, significant increase in HDL-c was recorded in all acute liver failure groups administrated with dried banana peels 5% and 10% comparing with control positive group. It was suggested that, consumption of fresh and dried banana peels may modify the risk of acute liver failure patients. Ó 2015 Production and hosting by Elsevier B.V. on behalf of Faculty of Agriculture, Ain Shams University.

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Section: Chemical Analysismentioning

confidence: 86%

The effect of banana peels supplemented diet on acute liver failure rats

Mosa

Khalil

2015

Annals of Agricultural Sciences

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“…Common banana Musaceae Flower Antioxidant [139][140][141] Psidium guajava L. Guava Myrtaceae Fruit Antioxidant [142,143] Capsicum frutescens L. Bird chili Solanaceae Fruit Antioxidant, LDLr [99,100,104,107,112] modulation effects and vasorelaxation properties Lycium chinense Mill.…”

Section: Sesbania Grandifoliamentioning

confidence: 99%

Antioxidant Research in Asia in the Period from 2000-2008

Hafidh¹,

Abdulamir²,

Bakar³

et al. 2009

American J. of Pharmacology and Toxicology

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Problem statement: Plant antioxidants are natural plant products that inhibit the adverse effects of the Reactive Oxygen Species (ROS) produced in plants. Thus, antioxidants enable plants to survive. Depending on this principle, human beings started using some plants' parts to cure from diseases many centuries ago, even before the discovery of microbes or disclosing the etiology of many human diseases. Shed light on the importance of diet and natural products that have proved of great health impact on human traditionally and scientifically, disclosing the central role of natural antioxidants in this matter. Moreover, this review tried to give an overview on the research has so far done in Asian countries particularly in the field of natural antioxidants during the period 2000-2008. Therefore, the aim of this review is to present a comprehensive index for the antioxidant property of herbs and plants that have been traditionally used as well as experimentally proved beneficial in these countries. Approach: We had compared Asian and other nation's diet in the popularity of the traditional medicine and the type of daily meal in respect to their antioxidants contents and valuable health promoting effects. Many literatures had been collected using online search engines and the main library of University Putra Malaysia. The gathered data had been arranged alphabetically in a table depending on the plant's scientific name, common name, the used part(s) and the family name. Results: The research had shown that there were seventy-six plants with proved antioxidant activity which had been well studied by Asian scientists in the chosen period of time. Conclusion: The antioxidant components of the natural products constitute the major source of human health promotion and maintenance. The nature is still the perfect source for health promotion and for the supplementation of safe drugs. Great attention is mandatory from all the scientists around the world to explore many underestimated plants with highly effective antioxidant activity.

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“…48 h after the injection, blood glucose concentration in all the surviving rats were estimated. Rats that were exhibiting plasma glucose concentration of 250 -350 mg/dl were considered to be diabetic and were used for the experiment (Dhanabal et al, 2005). Rats were divided into four groups (n = 6) and fasted for 18 h before the experiment.…”

Section: Effect Of Mesm On Alloxan Induced Diabetic Ratsmentioning

confidence: 99%

Effect of Swietenia macrophylla seeds on normal and alloxan-induced diabetic rats

Maiti¹,

Dewanjee²,

Sc³

2007

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe methanol extract of the seed of Swietenia macrophylla (Meliaceae) seeds were investigated for its hypoglycaemic activity in normal and alloxan induced diabetic rats. Seed extract suspended in aqueous Tween 80 solution, the graded doses were administered to normal and experimental diabetic rats for 10 days. Fasting blood glucose levels, serum lipid profiles and changes in body weight were evaluated in normal rats while the hepatic marker enzymes and liver glycogen levels were evaluated additionally in diabetic rats. The diabetic groups treated with the seed extract were compared with standard drug glibenclamide. The findings showed the significant antidiabetic potential of the extract in ameliorating the diabetic conditions in diabetic rats. The extract also has hypoglycaemic action in normal rats. A toxicity study has been performed for the extract, which revealed that the extract is safe to use even at the doses of 3.2 mg/kg of body weight orally. The result from the present investigation indicates good correlation between the folk use and scientific investigation.

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Hypoglycemic Effect of Ethanolic Extract of Musa sapientum on Alloxan-Induced Diabetes Mellitus in Rats and Its Relation with Antioxidant Potential

Cited by 16 publications

References 0 publications

The effect of banana peels supplemented diet on acute liver failure rats

The effect of banana peels supplemented diet on acute liver failure rats

Antioxidant Research in Asia in the Period from 2000-2008

Effect of Swietenia macrophylla seeds on normal and alloxan-induced diabetic rats

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