Hypoglycemic effect of camel milk powder in type 2 diabetic patients: A randomized, double‐blind, placebo‐controlled trial

Zheng, Yinhe; Wu, Fang; Zhang, Ming; Fang, Bing; Zhao, Liang; Dong, Lijie; Zhou, Xiaojuan; Ge, Shaoyang

doi:10.1002/fsn3.2420

Cited by 15 publications

(23 citation statements)

References 53 publications

(97 reference statements)

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“…Supporting our data, administration of camel milk to diabetic patients didn’t affect their appetite, food intake, or serum levels of appetite hormones, including ghrelin, PYY, glucagon-like peptide 1 (GLP-1), and pancreatic polypeptide (PP) (Zheng et al. 2021 ).…”

Section: Discussionsupporting

confidence: 71%

Camel milk protein hydrosylate alleviates hepatic steatosis and hypertension in high fructose-fed rats

Alshuniaber

Alshammari

Eleawa

et al. 2022

Pharmaceutical Biology

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Context Camel milk is used in traditional medicine to treat diabetes mellitus hypertension and other metabolic disorders. Objective This study evaluated the antisteatotic and antihypertensive effects of camel milk protein hydrolysate (CMH) in high fructose (HF)-fed rats and compared it with the effects afforded by the intact camel milk protein extract (ICM). Materials and methods Adult male Wistar rats were divided into 6 groups ( n = 8 each) as 1) control, 2) ICM (1000 mg/kg), 3) CMH (1000 mg/kg), 4) HF (15% in drinking water), 5) HF (15%) + ICM (1000 mg/kg), and 6) HF (15%) + CMH (1000 mg/kg). All treatments were given orally for 21 weeks, daily. Results Both ICM and CMH reduced fasting glucose and insulin levels, serum and hepatic levels of cholesterol and triglycerides, and serum levels of ALT and AST, angiotensin II, ACE, endothelin-1, and uric acid in HF-fed rats. In addition, both ICM and CMH reduced hepatic fat deposition in the hepatocytes and reduced hepatocyte damage. This was associated with an increase in the hepatic activity of AMPK, higher PPARα mRNA, reduced expression of fructokinase C, SREBP1, SREBP2, fatty acid synthase, and HMG-CoA-reductase. Both treatments lowered systolic and diastolic blood pressure. However, the effects of CMH on all these parameters were greater as compared to ICM. Discussion and conclusions The findings of this study encourage the use of CMH in a large-scale population and clinical studies to treat metabolic steatosis and hypertension.

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Section: Discussionsupporting

confidence: 71%

Camel milk protein hydrosylate alleviates hepatic steatosis and hypertension in high fructose-fed rats

Alshuniaber

Alshammari

Eleawa

et al. 2022

Pharmaceutical Biology

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“…In addition, these clinical trials reported that the dose of insulin required to the normalize glucose levels in blood was reduced in diabetic patients who received CM. Zheng et al recently reported an elegant clinical study on 14 type-2 diabetic patients supplemented with CM powder and showing CM decreased fasting blood glucose, serum cholesterol ( 14 ). By contrast, CM increased in serum content of the glucagon-like peptide 1 (GLP-1), known as a key regulator of insulin secretion by the pancreas ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

“…Zheng et al recently reported an elegant clinical study on 14 type-2 diabetic patients supplemented with CM powder and showing CM decreased fasting blood glucose, serum cholesterol ( 14 ). By contrast, CM increased in serum content of the glucagon-like peptide 1 (GLP-1), known as a key regulator of insulin secretion by the pancreas ( 14 ). Moreover, a comprehensive and a comparative study on one tribe of camel breeders in India who frequently consume CM showed a lower incidence risk of diabetes compared to other communities; plausibly due to consumption of CM ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, it is now accepted that CM has beneficial effects in human health with potential applications in various diseases and disorders including diabetes, cancer, inflammation, hypertension, infection (6)(7)(8)(9)(10). The antidiabetic properties of CM constitute the most studied aspect of CM using in vitro approaches as well as in vivo studies on animal models and diabetic patients (10)(11)(12)(13)(14). In these studies, various aspects related to diabetes such as glycemia, lipid profile, insulin secretion and resistance were studied and were found to be significantly improved by CM.…”

Section: Introductionmentioning

confidence: 99%

“…In these studies, various aspects related to diabetes such as glycemia, lipid profile, insulin secretion and resistance were studied and were found to be significantly improved by CM. In humans, the beneficial effects of CM in diabetes and its related disorders were even examined in many randomized clinical studies (9,(14)(15)(16)(17)(18)(19)(20). Mirmiran et al, have provided a comprehensive compilation of various animal and clinical studies highlighting the role of CM against diabetic complications (19).…”

Section: Introductionmentioning

confidence: 99%

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Camel Milk Targeting Insulin Receptor—Toward Understanding the Antidiabetic Effects of Camel Milk

et al. 2022

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Camel milk (CM) is known for its beneficial virtues in the human diet and health. This includes its antidiabetic properties demonstrated in many in vitro and in vivo studies. Nevertheless, the scientific rationale behind the molecular and cellular basis of such beneficial effects and the exact antidiabetic agent(s)/mechanism(s) are still elusive. In this review, we focused on the recent advances supporting the targeting of insulin receptor (IR) by CM components. Indeed, our recent work reported that CM proteins and derived peptides pharmacologically target IR in vitro leading to its activation and potentiation of insulin-mediated responses. The review describes the experimental approaches used to investigate the effects of CM on IR in vitro based on the fractionation of CM whey proteins to purify functional proteins and their hydrolysis by gastric proteases to generate bioactive peptides. In addition, we illustrated our cellular and molecular model consisting of studying the functional activity of CM fractions on IR and its downstream signaling pathways in the hepatocarcinoma (HepG2) and the human embryonic kidney (HEK293) cells using the bioluminescence resonance energy transfer (BRET), phosphorylation, and glucose uptake assays. Overall, our work demonstrated for the first time that CM lactoferrin and CM-derived bioactive peptides positively modulate IR and its related signaling pathways in HepG2 and HEK293 cells. As a conclusion, the pharmacological targeting of IR by CM sheds more light on the antidiabetic properties of CM by providing its molecular basis that may constitute a solid rationale for the development of new generation of antidiabetic tools from CM-derived proteins and peptides and the utilization of CM in the management of diabetes. The sequencing and the synthesis of the potent bioactive CM peptides may open promising perspectives for their application as antidiabetic agents.

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Long-range linkage disequilibrium events on the genome of dromedary camels as a signal of epistatic and directional positive selection

Bahbahani

2024

Heliyon

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Hypoglycemic effect of camel milk powder in type 2 diabetic patients: A randomized, double‐blind, placebo‐controlled trial

Cited by 15 publications

References 53 publications

Camel milk protein hydrosylate alleviates hepatic steatosis and hypertension in high fructose-fed rats

Camel milk protein hydrosylate alleviates hepatic steatosis and hypertension in high fructose-fed rats

Camel Milk Targeting Insulin Receptor—Toward Understanding the Antidiabetic Effects of Camel Milk

Long-range linkage disequilibrium events on the genome of dromedary camels as a signal of epistatic and directional positive selection

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