Hypoglycemic Coma, Jaundice, and Pure RBC Aplasia Following Chlorpropamide Therapy

Gill, Martin J.; Ratliff, David; Harding, L. K.

doi:10.1001/archinte.1980.00330170130040

Cited by 13 publications

(1 citation statement)

References 11 publications

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“…The relationship between erythropoietic failure and viral diseases was described in 1948. This clinical entity, today recognized as PRCA, is associated with thymoma [1], hemolytic states [2], autoimmune diseases [3], malignant diseases [4,5], and drugs [6]. Since we found our first two patients with AIDS-related PRCA in 1996 [7], a prospective search for this clinical condition in every patient with anemia and refractoriness to regular treatment was started.…”

Section: Introductionmentioning

confidence: 99%

Lamivudine-induced pure red cell aplasia

et al. 2000

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The aim of this report is to describe five patients with lamivudine-induced pure red cell aplasia, an association not previously described. We describe patients with unresponsive anemia in whom a complete study including blood cell counts, reticulocyte counts, hemolysis tests, and bone marrow aspiration was performed. Pure red cell aplasia was considered when anemia was associated with normal leukocyte and platelet counts with a corrected reticulocyte count below 1% and less than 5% bone marrow erythroid progenitors in the absence of positive hemolysis tests. Complete remission was considered when bone marrow erythroid progenitors were at least 16%. Five male patients had pure red cell aplasia with a median age of 32 years (range 29 to 37 years). Before lamivudine, they had hemoglobin >11.8 g/dl without transfusion requirements. After receiving the drug, hemoglobin dropped to 5.2 g/dl (4.3 to 6.1 g/dl) with high transfusion requirements and mean bone marrow erythroid progenitors of 1.84% (0 to 4%). Withdrawal of lamivudine was attempted to confirm the diagnosis. Seven weeks after stopping lamivudine, hemoglobin rose up to 12.8 g/dl (11 .3 to 13.8 g/dl) and bone marrow erythroid progenitors increased up to 25.6% (21 to 40%) without transfusion requirements. Lamivudine-induced pure red cell aplasia may be a cause of anemia unresponsive to conventional treatment in AIDS. Since lamivudine use in Mexico has been relatively short, we expect more cases to appear in the future.

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Section: Introductionmentioning

confidence: 99%

Lamivudine-induced pure red cell aplasia

et al. 2000

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Gastrointestinal Tract Complications of Diabetes Mellitus

Yang¹

1984

Arch Intern Med

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Drug‐Induced Pure Red Cell Aplasia

Thompson,

Gales

1996

Pharmacotherapy

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Pure red cell aplasia (PRCA) is an uncommon hematologic disorder characterized by the absence of erythroblasts in otherwise normal bone marrow. It is commonly an autoimmune disorder sometimes associated with a congenital error. It may also be acquired in association with thymomas, hematologic malignancies, human parvovirus B19 infection, drugs, and other disease states. Thirty drugs have been implicated as causative in PRCA, but most literature reports describe only one or two patients. Data evaluating possible mechanisms of drug‐induced PRCA are extremely limited, with conflicting results from different investigators. The criteria we used were at least five patients reported, reports from at least three separate investigators, and a minimum of one case of probable causality or better using a published assessment scale. With these criteria, phenytoin, azathioprine, and isoniazid had sufficient evidence of causality. All three are documented causes of PRCA and should be considered in any case of selective erythrocyte aplasia.

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Hypoglycemic Coma, Jaundice, and Pure RBC Aplasia Following Chlorpropamide Therapy

Cited by 13 publications

References 11 publications

Lamivudine-induced pure red cell aplasia

Lamivudine-induced pure red cell aplasia

Gastrointestinal Tract Complications of Diabetes Mellitus

Drug‐Induced Pure Red Cell Aplasia

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