Hypoglycemic Bioactivity of Novel Eco-Friendly Carbon Dots Derived from Traditional Chinese Medicine

Sun, Ziwei; Lu, Fang; Cheng, Jinjun; Zhang, Meiling; Zhu, Yafan; Zhang, Yaxue; Kong, Hui; Qu, Huihua; Zhao, Yan

doi:10.1166/jbn.2018.2653

Cited by 31 publications

(23 citation statements)

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“…As a result, they found that CDs existed in many charcoal drugs and structural characteristics, physicochemical properties and biological activities of CDs in different charcoal drugs were different (Sun et al. 2018). By research on CDs in charcoal drugs, such as carbonized Schizonepetae Herba , carbonized Cirsii Herba and carbonized Typhae Pollen , it was found that CDs existed in all charcoal drugs and were characterized by high water-solubility, good biocompatibility and low toxicity.…”

Section: Modern Research On Bleeding Stopping Of Charcoal Drugsmentioning

confidence: 99%

A review on charred traditional Chinese herbs: carbonization to yield a haemostatic effect

Chen

Yang

et al. 2019

Pharmaceutical Biology

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Context: Charcoal of Chinese drugs is a kind of special processing product in Chinese medicine and used for treatment of haemoptysis, hematemesis and haemorrhage in the clinic during ancient times. During carbonizing, significant changes occur in chemical constituents and the efficacy of haemostasis will be enhanced. But the quality control standard of ‘carbonizing retains characteristics’ should be followed. Objective: This review introduces the typical methods of carbonizing, which highlight current research progress on haemostatic substances of charcoal drugs so as to provide a reasonable explanation for the theory of haemostasis treated by charcoal medicine. Methods: English and Chinese literature from 2004 to 2019 was collected from databases including Web of Science, PubMed, Elsevier and CNKI (Chinese). Charcoal drug, chemical constituents, processing, haemostasis and carbon dots were used as the key words. Results: Charcoal drugs mainly play a haemostatic role and the effect can be classified into four types to stop bleeding: removing blood stasis, cooling blood, warming meridians and astringing. Changes in composition lead to changes in pharmacodynamics. Carbonizing methods and basic research on haemostasis material in charcoal drugs have also been summarized. Conclusions: This review summarizes the classification of charcoal drugs and highlights the possible material bases for the haemostatic effect of charcoal drugs in recent years, providing new insights to future research.

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Section: Modern Research On Bleeding Stopping Of Charcoal Drugsmentioning

confidence: 99%

A review on charred traditional Chinese herbs: carbonization to yield a haemostatic effect

Chen

Yang

et al. 2019

Pharmaceutical Biology

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“…[11][12][13][14] We have reported that the carbonisata-derived CDs of drugs such as Junci Medulla, 15 Schizonepetae Spica, 16 Phellodendri Cortex, 13 and Pollen Typhae 17 have promising hemostatic bioactivity. Moreover, our group has identified that other applications of carbon nano-ingredients, for example, mulberry silkworm cocoon-derived carbon dots possess antiinflammatory; 18 Jiaosanxian carbonisata-derived CDs were found to effectively regulate blood sugar; 19 and Puerariae lobatae Radix carbonisata-derived CDs were shown to possess anti-gout activity. 20 Therefore, our follow-up research is more focused on other applications (other than hemostasis) of charcoal-processed drugs.…”

Section: Discussionmentioning

confidence: 99%

<p>Effect of <em>Lonicerae japonicae</em> Flos Carbonisata-Derived Carbon Dots on Rat Models of Fever and Hypothermia Induced by Lipopolysaccharide</p>

Wu¹,

Zhang²,

Cheng³

et al. 2020

IJN

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Introduction: A correlation is established between the efficacy of Chinese herbal medicine and its charcoal drugs. Lonicerae japonicae Flos (LJF) is commonly used to treat fever, carbuncle, and tumors, among others. LJF Carbonisatas (LJFC) is preferred for detoxifying and relieving dysentery and its related symptoms. However, the mechanisms underlying the effects of LJFC remain unknown. Aim: The aim of this study was to explore the effects of LJFC-derived carbon dots (LJFC-CDs) on lipopolysaccharide (LPS)-induced fever and hypothermia rat models. Methods: LJFC-CDs were characterized using transmission electron microscopy, highresolution transmission electron microscopy, Fourier-transform infrared, ultraviolet, fluorescence, X-ray photoelectron spectroscopy, X-ray diffraction and high-performance liquid chromatography. The anti-inflammatory effects of LJFC-CDs were evaluated and confirmed using rat models of LPS-induced fever or hypothermia. Results: The LJFC-CDs ranged from 1.0 to 10.0 nm in diameter, with a yield of 0.5%. LJFC-CDs alleviated LPS-induced inflammation, as demonstrated by the expression of tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 and the recovery of normal body temperature. Conclusion: LJFC-CDs may have an anti-inflammatory effect and a potential to alleviate fever and hypothermia caused by inflammation.

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“…For example, CDs have been used in drug delivery [6,7], bioimaging [8,9], optical imaging, and sensing [10,11]. Of note, an increasing trend has been observed in research on the self-activities of CDs such as haemostatic [12][13][14], hypoglycaemic [15], peroxidase-like [16], and bacteriostatic [17] activities. However, in-depth investigations of CDs may be necessary, especially those used in medical-and technologyrelated fields.…”

Section: Introductionmentioning

confidence: 99%

“…However, the active ingredients and mechanisms of action of carbonised MSCs have always been ambiguous. Inspired by previous studies on the active ingredients of other charcoal drugs [13][14][15], we focussed on CDs, which are produced during charcoal processing, but not on raw herbs.…”

Section: Introductionmentioning

confidence: 99%

Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties

Wang

Zhang

Kong

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Mulberry silkworm cocoon (MSC) carbonisata has been used for the treatment of inflammatory diseases for hundreds of years; however, after years of research efforts, little information is available on its antiinflammatory components and underlying mechanism. We developed novel carbon dots (CDs) derived from MSC carbonisata (MSC-CDs), for the first time, with an average diameter of 2.26-9.35 nm and a quantum yield (QY) of 6.32%. The MSC-CDs were prepared using a modified pyrolysis method, and no further modification and external surface passivation agent was required. With abundant surface groups, MSC-CDs showed distinct solubility and bioactivity. In this study, we innovatively used three classical experimental models of inflammation to evaluate the anti-inflammatory bioactivity of MSC-CDs. The results indicated that MSC-CDs exhibited marked anti-inflammatory bioactivity which was likely mediated by inhibition of the expression of interleukin-6 and tumour necrosis factor-a. These results suggest that MSC-CDs possess a remarkable anti-inflammatory property, which provides evidence to support further investigation of the considerable potential and effective material basis of this traditional Chinese medicine.

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Hypoglycemic Bioactivity of Novel Eco-Friendly Carbon Dots Derived from Traditional Chinese Medicine

Cited by 31 publications

References 0 publications

A review on charred traditional Chinese herbs: carbonization to yield a haemostatic effect

A review on charred traditional Chinese herbs: carbonization to yield a haemostatic effect

<p>Effect of <em>Lonicerae japonicae</em> Flos Carbonisata-Derived Carbon Dots on Rat Models of Fever and Hypothermia Induced by Lipopolysaccharide</p>

Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties

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