Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats

Wang, Yanwen; Campbell, T. G.; Perry, Ben D.; Beaurepaire, Cécile; Qin, Ling

doi:10.1016/j.metabol.2010.02.005

Cited by 121 publications

(90 citation statements)

References 54 publications

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“…The present study demonstrated that type 2 DM was characterized by significant increase in body weight, fasting blood sugar, serum TC, TGs, LDL with significant decrease in animal survival and serum HDL. Previous studies reported similar findings such as Wang et al [25], Khanra et al [26] and Srimaroeng et al [27]. Activation of hormone sensitive lipase in DM (normally inhibited by insulin) which increases the mobilization of free fatty acids from the peripheral fat deposits to blood stream might explain hyperlipidemia demonstrated in the present study.…”

Section: Discussionsupporting

confidence: 90%

Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats

Mousalamy¹,

Al-Shatri²

2016

Biochemistry & Physiology: Open Access

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Objective: The present study examined the effects of aqueous and methanolic extracts of palm dates (fruits and seeds) on diabetic nephropathy in a rat model of type 2 DM.Methods: Sixty male albino rats subdivided into a) normal control (NC) group, b) diabetic control (DM) group, c) aqueous fruit extract (AFE) group, d) methanolic fruit extract (MFE) group, e) aqueous seed extract (ASE) group and f) methanolic seed extract (ASE) group. Treatment with both extracts done for 15 weeks after induction of type 2 DM. by the end of experiment fasting blood glucose, serum lipid profile, creatinine, urea, uric acid, urinary albumin excretion, kidney tissue MDA, catalase, SOD, GSH were measured and kidney histopathological examination was done.Results: Diabetic untreated rats showed significant hyperglycemia and hyperlipidemia and deterioration in kidney functions and morphology with enhanced oxidative stress in kidney tissues. On other hand, rats treated with either aqueous or methanolic fruit or seed extracts showed significant improvement in all studied parameters compared to DM group (p<0.05). However, the effects of fruit extracts especially aqueous extract were more powerful than seed extracts. Conclusion:Aqueous and methanolic fruit and seed extracts of palm date protect kidneys from diabetic nephropathy in rats which might be due to their antioxidant properties.Citation: El-Mousalamy AMD, Hussein AAM, Mahmoud SA, Abdelaziz A, Shaker G (2016) Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats. Biochem Physiol 5: 205.

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Section: Discussionsupporting

confidence: 90%

Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats

Mousalamy¹,

Al-Shatri²

2016

Biochemistry & Physiology: Open Access

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“…Intragastric administration of berberine at a dose of 100 mg/kg/d for 2 weeks or 250 mg/kg/d (orally) for 4 weeks, decreased the level of FBG in mice (Tang et al, 2006;Wang et al, 2010;Zhang et al, 2008). In this study, the DM type 2 mice that received berberine daily at a dose of 100 mg/kg/d for 2 weeks had the AUC level of FBG comparable with the glibenclamide-treated DM type 2 with the lowered of those than the non-treated DM type 2.…”

Section: Discussionmentioning

confidence: 97%

Improvement of superoxide dismutase and catalase in streptozotocin–nicotinamide-induced type 2-diabetes in mice by berberine and glibenclamide

Chatuphonprasert

Lao-ong

Jarukamjorn

2013

Pharmaceutical Biology

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Context: Diabetes mellitus (DM) type 2 is a chronic disease characterized by hyperglycemia and insulin resistance. Oxidative stress participates in development and progression of DM, in which changes of superoxide dismutase (SOD) and catalase (CAT) were noted in DM mice. Berberine has been widely used as an alternative medicine and proved to be effective for the treatment of DM and dyslipidemia. Objective: Impacts of berberine on transcriptional regulation of SOD and CAT and their enzyme activities, including the level of malondialdehyde (MDA) formation, were examined in the DM type 2-induced mice to clarify its antioxidation potential, compared with a common hypoglycemic drug, glibenclamide. Materials and methods: Noninsulin-dependent diabetes was induced in mice by a single intraperitoneal streptozotocin-nicotinamide injection. Diabetic mice were treated daily with glibenclamide (10 mg/kg/d) and/or berberine (100 mg/kg/d) for 2 weeks. The fasting blood glucose and the MDA levels in the mouse liver, brain and kidneys were monitored using Glucometer Õ (Accu-Check Õ Advantage II Performa kits, Roche Diagnostics, Germany) and thiobarbituric acid substance assay, respectively. The expression of SOD and CAT mRNA were determined in the mouse liver and the activities of SOD and CAT enzymes were determined in mouse liver, brain and kidneys, respectively. Results: Berberine exhibited similar hypoglycemic potential as glibenclamide to lower area under the curve of the fasting blood glucose. In DM type 2 mice, berberine increased the hepatic CuZn-SOD mRNA expression and the kidney SOD and CAT activities to normal levels. Moreover, DM-induced lipid peroxidation by increasing of MDA levels in both the liver and brain and lipid peroxidation status was restored by berberine. Conclusion: Berberine possessed hypoglycemic properties and strong potential to improve the oxidant-antioxidant balance, though the combination treatment of berberine and glibenclamide did not show additional benefit over the treatment with berberine alone.

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“…Some alkaloids are known hypoglycemic agents. For instance berberine, a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids has been used successfully in experimental models of diabetes mellitus, berberine was shown to possess insulin sensitizing effect (Wang et al, 2010). Also, flavonoids, being polyphenolics, are known to be hypoglycemic.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antihyperglycemic, antiradical and acute oral toxicity activities of aqueous leaves extract of Moringa oleifera Lam (Moringaceae) from Benin in normal rats

Fernand¹,

Bertrand²,

Pascal³

et al. 2017

Afr. J. Biotechnol.

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Moringa oleifera is a commonly cultivated plant in the world. It has a high economic impact owing to its medicinal and nutritional values. Leaves of M. oleifera also contain various constituents that are useful for therapeutic purposes. The aim of this study is (i) to perform phytochemical screening, and to check antiradical and antihyperglycaemic activities of M. oleifera aqueous leaves extract (ii) to control the impact of this aqueous extract on the liver parameters of wistar rats. The analysis was carried out on a few large families of bioactive molecules such as triterpenoids, alkaloids, anthraquinones, coumarins, flavonoids, saponins, tannins, anthocyanes, leucoanthocyanes, reducing sugar, mucilage and cyanogenic. With a concentration of 2.47 ± 0.26 mmol EAA/mg, the plant has a good antioxidant activity. Antihyperglycemic capacity was evaluated by using oral glucose tolerance test. The α,α-diphenyl-β-picrylhydrazyl (DPPH) method was used to show antiradical activity. The impact of aqueous leaves extract of M. oleifera on some biochemical parameters of Wistar rats (150 to 200 g) was shown. The contents of total phenolic, flavonoids and condensed tannins were respectively 46.242±2.44 (mmolEAA/mg of extract); 10.80±0.64 (mg Eq of rutine/mg of extract); 2.85±1.018 (mg Eq of catechine/mg of extract). The results of the acute oral toxicity test showed that the dose of 2000 mg/kg was non-toxic to the rats. The haematological and blood parameters did not change after administration of the plant aqueous extract. Glycemia reduction was observed with the dose of 500 mg/kg. The important results obtained in this study explain the abundant use of this plant by the populations in the treatment of diabetes. However, it would be necessary to confirm the non-toxicity of the plant by histological studies of the liver and kidneys.

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Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats

Cited by 121 publications

References 54 publications

Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats

Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats

Improvement of superoxide dismutase and catalase in streptozotocin–nicotinamide-induced type 2-diabetes in mice by berberine and glibenclamide

Evaluation of antihyperglycemic, antiradical and acute oral toxicity activities of aqueous leaves extract of Moringa oleifera Lam (Moringaceae) from Benin in normal rats

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