Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus

Kim, Kwanghee; Kim, Hyunyul; Kwon, Jeunghak; Lee, Sung-Won; Kong, Hyunseok; Im, Sun A.; Lee, Young Hee; Lee, Young Ran; Oh, Sun Tack; Jo, Tae Hyung; Park, Young In; Lee, Chong Kil; Kim, Kyungjae

doi:10.1016/j.phymed.2009.02.014

Cited by 137 publications

(101 citation statements)

References 27 publications

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“…The MBBP can effectively reduce liver tissue damage and protect the liver function. Further, lipid metabolism in diabetic mice was abnormal, but after treatment with MBBP, TG, CHOL, and LDL-C significantly decreased and HDL-C increased, which is consistent with the results described by Kim et al [29]. MBBP can effectively improve dyslipidemia and regulate lipid metabolism in diabetic mice.…”

Section: Discussionsupporting

confidence: 90%

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Yin

Liu

Zhang

2017

Food & Nutrition Research

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This experiment, based on the previous study on R. mori, introduces whole mulberry branch powder into the diet to treat diabetic mice. Mulberry branch bark powder (MBBP) was administered orally to streptozotocin (STZ)-induced type II diabetic (T2D) mice to investigate hypoglycemic effects. After a 4-week period of diet consumption containing 5%, 10% and 20% MBBP, the fasting blood glucose, body weight and the related western blotting were measured, pathologic and immunohistochemical were observed. The 20% MBBP group showed a significant reduction in hyperglycemia and hyperinsulinemia; fasting blood glucose and insulin decreased from 25.0 to 14.8 mmol/L and 26.5 to 16.0 mU/L, respectively. Pathologic and immunohistochemical observation showed that MBBP administration lead to the repair of pancreas cells and restoration of insulin secretion. Dietary MBBP was associated with the decrease in the contents of 3, 4-methylenedioxeamphetamine, 8-OHdG, aspartate aminotransferase, and alanine aminotransferase, and the increase in antioxidative ability and glucose tolerance. Western blotting (WB) analysis suggested that MBBP decreased the TNF-α levels, thus relieving inflammation and improving liver function. It also led to the downregulation of apoptosis factor expression. WB also confirmed that MBBP enhanced the gene expression of the key enzymes: insulin receptor, insulin receptor substrate, p-AKT, GSK3β, glycogen synthase, G6Pase and phosphoenolpyruvate carboxykinase, which are related to glucose metabolism in the liver, and increase the expression of the genes PDX-1, GLUT2, MafA, and glucokinase, related to insulin secretion. Thus, oral administration of MBBP regulated insulin secretion and effectively maintained normal levels of glucose metabolism in mice, which may be done by improving the antioxidant capacity and activating insulin signaling with T2D..

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Section: Discussionsupporting

confidence: 90%

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Yin

Liu

Zhang

2017

Food & Nutrition Research

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“…We previously demonstrated that PAG improved the insulin resistance in DIO mice (Kim et al, 2009b). These findings led to the assumption that an aloe formula showing high hypoglycemia and hypolipidemia activities would be beneficial for the improvement of insulin resistance in a T2D model.…”

Section: Discussionmentioning

confidence: 95%

Down-Regulation of Adipogenesis and Hyperglycemia in Diet-Induced Obesity Mouse Model by Aloe QDM

Kong¹,

Lee²,

Shin³

et al. 2010

Biomolecules and Therapeutics

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-Obesity-induced disorders contribute to the development of metabolic diseases such as insulin resistance, fatty liver diseases, and type 2 diabetes (T2D). In this study, we evaluated the hypoglycemic and hypolipidemic effects of aloe formula in high fat diet (HFD)-fed C57BL/6N mice. Male mice fed HFD for 28 weeks received a supplement of aloe formula, PAG, ALS, Aloe QDM, and an Aloe QDM complex for a further 8 weeks and were then compared with regular diet fed mice. After the experimental period, the blood glucose levels of the Aloe QDM complex-and PGZ-supplemented mice were significantly lower than those of the HFD-fed mice. Aloe formula, especially the Aloe QDM complex, and the PGZ treatment group profoundly affected the IPGTT and HOMA-IR. Immunochemistry was done for the morphological observation and the resulting sizes of adipocytes around the epididymis were significantly decreased when comparing the aloe formula-treated and HFD-fed groups. Further, aloe formula decreased mRNA expression of fatty acid synthesis enzymes and led to reduced hepatic steatosis in both liver and WAT. These results suggest that supplementation of Aloe QDM complex in the HFD-fed mice improved insulin resistance by lowering blood glucose levels and reducing adipocytes. Our data suggest that dietary aloe formula reduces obesity-induced glucose tolerance by suppressing fatty acid synthesis in the WAT and liver, both of which are important peripheral tissues affecting insulin resistance. The Aloe QDM complex could be used as a nutritional intervention against T2D.

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“…Many authors have found blood glucose lowering, hypolipidimic effect in Rats and Mice. [8][9][10] Other authors found Aloe vera to be having wound healing activity and anti-psoriatic property. [11][12][13] Using Pubmed and Google scholar as search engines, we found that there are many studies with ethanolic extract of Aloe vera but a few only with water soluble extract of Aloe vera.…”

Section: Discussionmentioning

confidence: 99%

Assessment of oral hypoglycaemic activity of water soluble extract of aloe vera and its interaction with glipizide in alloxan induced diabetic Wistar Rats

Tiwari

Gudsurkar

2017

Int J Basic Clin Pharmacol

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Background: Assessment of oral hypoglycaemic activity of water soluble extract of Aloe vera and its interaction with Glipizide in Alloxan induced diabetic Wistar rats.Methods: Under standard condition of testing, alloxan induced diabetic rats were kept in fasting state of 8 hours and then glucose in dose of 1gm/kg was given PO by feeding tube. There after water soluble extract of aloe vera in dose of 200mg/kg BW dissolves in 1ml of Distilled water (DW) to test group 1, Glipizide in dose of 2.5mg/kg BW dissolved in 1ml DW was given to standard group. Test group 2 received combination of Aloe vera 200mg/kg BW and Glipizide in dose of 2.5mg/kg BW dissolved in 1ml Dw. Control group received 1ml of Distilled water. Blood sugars levels of all Rats in each group were checked with Glucometer.Results: Clinically and statistically significant glucose lowering effect was observed in groups administered with Aloe vera and better results were observed in group receiving Aloe vera and Glipizide combination.Conclusions: Water soluble extract of aloe vera has significant hypoglycaemic activity and the results showed that co-administration of Aloe vera and Glipizide has superior hypoglycaemic activity compared to Aloe vera and Glipizide given Individually.

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Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus

Cited by 137 publications

References 27 publications

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Down-Regulation of Adipogenesis and Hyperglycemia in Diet-Induced Obesity Mouse Model by Aloe QDM

Assessment of oral hypoglycaemic activity of water soluble extract of aloe vera and its interaction with glipizide in alloxan induced diabetic Wistar Rats

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