Hypoglycemic and hypolipidemic effects of total glycosides of Cistanche tubulosa in diet/streptozotocin-induced diabetic rats

Zhu, Kuiniu; Meng, Zhaoqing; Tian, Yushan; Gu, Rui; Xu, Zhong-Kun; Fang, Hui; Liu, Wenjun; Huang, Wen-Zhe; Ding, Gang; Xiao, Wei

doi:10.1016/j.jep.2021.113991

Cited by 31 publications

(21 citation statements)

References 36 publications

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“…Another study demonstrated that verbascoside inhibited various inflammatory mediators in the primary rat chondrocytes treated with IL-1β through the MAPK pathway as well [ 35 ]. Moreover, recent studies have suggested verbascoside possessed the anti-diabetic potential since it has been reported to lower hyperglycemia and hyperlipidemia in diet/STZ-induced diabetic rats [ 36 ]. In a KK-Ay mouse model of type 2 diabetes, verbascoside was found to enhance lipolysis and fatty acid oxidation by inducing mRNA expression of adipose triglyceride lipase through the AMP-activated protein kinase (AMPK) pathway [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Verbascoside Protects Gingival Cells against High Glucose-Induced Oxidative Stress via PKC/HMGB1/RAGE/NFκB Pathway

Hsieh

Chu

et al. 2021

Antioxidants

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Impaired wound healing often occurs in patients with diabetes and causes great inconvenience to them. Aside from the presence of prolonged inflammation, the accumulation of oxidative stress is also implicated in the delayed wound healing. In the present study, we tested the effect of verbascoside, a caffeoyl phenylethanoid glycoside, on the improvement of cell viability and wound healing capacity of gingival epithelial cells under high glucose condition. We showed that verbascoside attenuated the high glucose-induced cytotoxicity and impaired healing, which may be associated with the downregulation of oxidative stress. Our results demonstrated that verbascoside increased the activity of the antioxidant enzyme SOD and reduced the oxidative stress indicator, 8-OHdG, as well as apoptosis. Moreover, verbascoside upregulated the PGC1-α and NRF1 expression and promoted mitochondrial biogenesis, which was mediated by suppression of PKC/HMGB1/RAGE/NFκB signaling. Likewise, we showed the inhibitory effect of verbascoside on oxidative stress was via repression of PKC/HMGB1/RAGE/NFκB activation. Also, our data suggested that the PKC-mediated oxidative stress may lead to the elevated production of inflammatory cytokines, IL-6 and IL-1β. Collectively, we demonstrated that verbascoside may be beneficial to ameliorate impaired oral wound healing for diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Verbascoside Protects Gingival Cells against High Glucose-Induced Oxidative Stress via PKC/HMGB1/RAGE/NFκB Pathway

Hsieh

Chu

et al. 2021

Antioxidants

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“…It is now often processed as capsule, wine, tea and other health products [ 3 ]. Modern research has demonstrated that the polysaccharides, echinacoside, verbascoside, geniposidic acid and catalpol in Cistanche have inestimable hypoglycaemic [ 4 ], anti-inflammatory [ 5 ] and anti-Alzheimer’s disease effects and protect various organ systems in the body [ 6 ]. However, fresh Cistanche samples have high moisture contents and tend to spoil during the harvest, transport and storage processes.…”

Section: Introductionmentioning

confidence: 99%

Effect of an Ultrasound Pre-Treatment on the Characteristics and Quality of Far-Infrared Vacuum Drying with Cistanche Slices

Jiang¹,

Wan²,

Zang³

et al. 2022

Foods

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In this study, the effect of an ultrasound (US) pre-treatment on the process of drying Cistanche slices through far-infrared vacuum drying was investigated with various experimental factors, including the US treatment time (25, 35, 45 min), frequency (20, 40, 60 kHz) and power (150, 180, 210 W). The results showed that compared with the samples without US, the material drying time after the US treatment was reduced by 16–36.8%. The effective moisture diffusion coefficients of Cistanche slices under different US conditions ranged from 1.61122 × 10−8 to 2.39274 × 10−8 m2/s, which agreed with food processing ranges. In addition, the phenylethanoid glycoside, iridoid, polysaccharide, total phenol and total flavonoid contents in Cistanche were significantly increased after US pre-treatment. However, the dried products obtained with the 45 min US treatment had greatly damaged internal structures, collapsed and seriously deformed surfaces, and low contents of active ingredients. Overall, the US pre-treatment could significantly improve the drying quality of Cistanche slices.

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“…The administration of high fructose and low dose STZ to the rats led to significant increase in blood glucose level, polyuria and polyphagia. Furthermore, insulin resistance and impaired insulin secretion are vital parameters contributing to the onset of hyperglycemia [33]. Whereas, glucose tolerance test and HbA1c are two of the most frequently used approach for the detection of glucose disposal abnormalities and glycaemic control, respectively [34][35][36].…”

Section: Discussionmentioning

confidence: 99%

“…Insulin resistance and persistent hyperglycemia results in excessive production of reactive radicals (ROS and RNS) which promotes oxidative stress as well as alterations in the lipids and protein. The effects of these oxidative cytotoxic events can initiate glycoxidation, lipid peroxidation, inflammation and oxidative damages [33,45]. The vicious cycle between oxidative stress triggered increase in inflammatory cytokines and vice versa in diabetes is majorly responsible for most secondary complications associated with diabetes [3,33].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Efficacy of Polyphenol-Rich Fraction of Boesenbergia rotunda in Diabetic Rats: A Focus on Hypoglycemic, Antihyperlipidemic, Carbohydrate Metabolism, Antioxidant, Anti-Inflammatory and Pancreato-Protective Activities

Wang¹,

Liu²,

Shu³

et al. 2022

Front. Biosci. (Landmark Ed)

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Introduction: Boesenbergia rotunda is a famous culinary/medicinal herb native to Southeast Asia region and it is traditionally used in the treatment of several diseases. This study investigated the anti-diabetic properties of Boesenbergia rotunda polyphenol extract (BRE) in high fructose/streptozotocin-induced diabetic rats. Method: The in vitro antioxidant activity was evaluated using DPPH and ABST colorimetric assays, while the Folin-Ciocalteu method was used for the total phenolic content of BRE. For diabetes induction, a combination of high fructose solution and streptozotocin was administered to the rats and diabetic rats were orally administrated with BRE (100 and 400 mg/kg) for 5 weeks. The fasting blood glucose, body weight gain, food and water consumption were determined during the treatment period. Results: BRE showed excellent in vitro DPPH and ABTS scavenging activity with high phenolic content. BRE significantly lowered fasting blood glucose level, HbA1c, lipid profile, hepatorenal biochemical parameters and ameliorated the IPGTT in diabetic rats. Additionally, BRE reversed body weight loss, attenuated food and water intake, serum insulin level, pancreatic β-cell function and pancreatic cell morphology. Furthermore, fructose 1,6 biphosphatase, glucose-6-phosphatase, malondialdehyde (MDA) and proinflammatory cytokines levels were also ameliorated in the BRE-treated diabetic rats, while pancreatic antioxidant enzymes activities (GSH, SOD and CAT) were significantly increased in the treated rats. Conclusions: In conclusion, the results showed that BRE effectively displayed antidiabetic effects and has possible value for antidiabetic oral medication.

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Hypoglycemic and hypolipidemic effects of total glycosides of Cistanche tubulosa in diet/streptozotocin-induced diabetic rats

Cited by 31 publications

References 36 publications

Verbascoside Protects Gingival Cells against High Glucose-Induced Oxidative Stress via PKC/HMGB1/RAGE/NFκB Pathway

Verbascoside Protects Gingival Cells against High Glucose-Induced Oxidative Stress via PKC/HMGB1/RAGE/NFκB Pathway

Effect of an Ultrasound Pre-Treatment on the Characteristics and Quality of Far-Infrared Vacuum Drying with Cistanche Slices

Therapeutic Efficacy of Polyphenol-Rich Fraction of Boesenbergia rotunda in Diabetic Rats: A Focus on Hypoglycemic, Antihyperlipidemic, Carbohydrate Metabolism, Antioxidant, Anti-Inflammatory and Pancreato-Protective Activities

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