Hypoglycemic and Hypolipidemic Activities of Methanolic Extract of Sphenocentrum jollyanum on Streptozotocin-induced Diabetic Wistar Rats

Alese, Margaret Olutayo

doi:10.9734/ejmp/2014/7618

Cited by 10 publications

(6 citation statements)

References 16 publications

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“…It states that around 85–90% of the world's population consumes traditional herbal medicines [ 2 ]. In recent decades, studies on phytochemical constituents of medicinal plant and its pharmacological activities have received wide attention [ 3 – 6 ]. WHO has emphasized the need to ensure the quality of medicinal plant products using modern techniques with the application of suitable standards.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profiling of Leaf, Stem, and Tuber Parts ofSolena amplexicaulis(Lam.) Gandhi Using GC-MS

Krishnamoorthy¹,

Paulsamy²

2014

International Scholarly Research Notices

138

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Objective. To explore the possible bioactive compounds in the methanolic extracts of leaf, stem, and tuber parts of the medicinal climber, Solena amplexicaulis, using GC-MS. Methods. GC-MS analysis of the plant extracts were performed by using GC-MS-5975C [Agilent] and mass spectra of the compounds found in the extract was matched with the data in the library of National Institute of Standards and Technology (NIST). Results. Thirty-five compounds were determined to be present in the parts studied. The active principles with their retention time, molecular formula, molecular weight, peak area, structure, category of the compounds, and activities were predicted. The most prevailing compounds were phytol (38.24%) in leaf, 4-(4-ethoxyphenyl) but-3-en-2-one (56.90%) in stem, and 9,17-octadecadienal, (Z)- (21.77%) in tuber. Conclusion. This study revealed that the species S. amplexicaulis is a good source of many bioactive compounds like terpenes, triazines, esters, alkanes, alcohols, hydrocarbons, aldehydes, amides, and so forth. That justifies the traditional usage of this species.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Profiling of Leaf, Stem, and Tuber Parts ofSolena amplexicaulis(Lam.) Gandhi Using GC-MS

Krishnamoorthy¹,

Paulsamy²

2014

International Scholarly Research Notices

138

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“…Ethanol extracts of S. jollyanum leaf at concentrations of 50, 100, 200 mg/kg significantly ( p < 0.05) lowered the blood glycemic index of alloxan-induced diabetic rabbits in a dose-dependent manner, with plasma glucose level of 200.2 mg/100 mL (42.8%) at 200 mg/kg [ 31 ]. Alese et al [ 32 ] reported that the methanol root extract demonstrated hypoglycemic effects on streptozotocin-induced diabetic Wistar rats. Oral dosage of 200 mg/kg extracts for 2 weeks caused a significant decrease in blood glucose to 6.62 mmol/L relatively to the uncontrolled group with blood glucose level of 16.3 mmol/L.…”

Section: Pharmacological and Biological Activitiesmentioning

confidence: 99%

“…It was noticed that there was no observable difference in total cholesterol (TC) amount of the extract- and glinbenclamide-administered animals. Additionally, there was a significant ( p < 0.02) difference in antiartherogenic index (AAI) and high-density lipoprotein level in extract-treated group (0.77 ± 0.02 mmol/L) when compared to untreated infected group (0.85 ± 0.02 mmol/L) [ 32 ].…”

Section: Pharmacological and Biological Activitiesmentioning

confidence: 99%

A Review on Ethno-Medicinal and Pharmacological Activities of Sphenocentrum jollyanum Pierre

2017

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Sphenocentrum jollyanum Pierre is a member of a diverse family of plants known as Menispermaceae. They are famous for a plethora of important biological functions. S. jollyanum is a shrub native to the tropical forest zones of West Africa and thrives in deep shade. It is widely cultivated in Cameroun, Sierra Leone, Nigeria, Ghana, and Côte d’Ivoire. S. jollyanum is employed in folk medicine as a cure for wounds, fever, coughs, high blood pressure, breast tumor, constipation, and as an aphrodisiac. Phytochemical investigations revealed that the plant is a rich source of secondary metabolites such as annin, alkaloids, saponins, and flavonoids. Pharmacological activities include anti-diabetic, anti-inflammatory, anti-bacterial, anti-viral, anti-malarial, angiogenic, and anxiogenic. Thus, this present review summarizes the phytochemical and nutritional constituents and important biological studies on various crude extracts, fractions, and isolated principles of all morphological organs of S. jollyanum.

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“…Amidu et al (2008), reported the presence of alkaloids, terpenoids, and flavonoids in the ethanol root concentrate of Sphenocentrum jollynum. S. jollyanum possesses anti-diabetic (Alese et al, 2014), antioxidant (Olorunnisola and Afolayan, 2013), anti-inflammatory (Olorunnisola et al, 2017), anti-allergic (Olorunnisola et al, 2017), anti-bacterial (Koleosho et al, 2013), anti-viral (Moody et al, 2002 and antimalaria (Olorunnisola and Afolayan, 2013). Cnestis ferruginea has been found to contain isoflavone, coumarin, and anthocyanins which have been ascribed to be responsible for antidiabetic activities in some plants (Bhatt et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Anti-diabetic impact of ‘Aju Mbaise’ herbal cocktail in streptozotocin-induced diabetic female rats

Nnadiukwu,

Monago-Ighorodje,

Chuku

2024

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This study evaluated the hypoglycaemic potential of ‘Aju Mbaise’ herbal mixture. Female Wistar rats of 40 – 50 g and fifty-four (54) in number were obtained and housed at the animal house of the Department of Pharmacology, University of Port Harcourt. They were assembled into 6 groups of 9 rats each. Group I served as the normal control (NC) while the remaining five groups were induced with diabetes type 2 using high-fat diet (HFD) for about 8 weeks and streptozotocin at 35 mg/kg body weight. Group II was the diabetic control (DC) while the other groups (III, IV, V & VI) were administered 7.2 mg/kg metformin and the cocktail extract at three different concentrations of 500 mg/kg, 250 mg/kg, and 100 mg/kg respectively. Biochemical tests were conducted after twelve weeks of treatment. The blood glucose concentration was estimated using the Accu-check glucometer and glucose strips while the rest biomarkers were analyzed using their specific test kits. Diabetes mellitus was confirmed after HFD and STZ administration. Result obtained showed that the normal and metformin control groups recorded significant (p<0.05) lower blood glucose, liver enzymes (AST, ALT, & ALP), urea, and creatinine, as well as higher total protein concentrations when compared to the diabetic control and treated groups. Also, significant (p<0.05) reduction in blood glucose, liver enzymes, urea, and creatinine, as well as increase in total protein concentrations was recorded by the treated groups when compared to the diabetic control group. This study revealed the potential hypoglycaemic effect of ‘Aju Mbaise’ herbal cocktail.

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Hypoglycemic and Hypolipidemic Activities of Methanolic Extract of Sphenocentrum jollyanum on Streptozotocin-induced Diabetic Wistar Rats

Cited by 10 publications

References 16 publications

Phytochemical Profiling of Leaf, Stem, and Tuber Parts ofSolena amplexicaulis(Lam.) Gandhi Using GC-MS

Phytochemical Profiling of Leaf, Stem, and Tuber Parts ofSolena amplexicaulis(Lam.) Gandhi Using GC-MS

A Review on Ethno-Medicinal and Pharmacological Activities of Sphenocentrum jollyanum Pierre

Anti-diabetic impact of ‘Aju Mbaise’ herbal cocktail in streptozotocin-induced diabetic female rats

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