Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice

Adeneye, AA; Amole, O.O.; Adeneye, Adeniyi

doi:10.1016/j.fitote.2006.05.030

Cited by 86 publications

(63 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The phytochemicals found present in the leaf of P. amarus include: flavonoids, tannins, saponins, alkaloids, terpenoids, steroids and cardiac glycosides. Flavonoids present in this plant has been shown to possess many pharmacological properties such as: anti-oxidant activities, anti-inflammatory activities, anti-cancer activities and anti-microbial effects hence, flavonoids may have a contributory effect to its fertility properties and other pharmacological effects the plant possesses ( Joy and Kuttan, 1998;Kassuya et al, 2003;Adeneye, 2006).Favonoids as an anti-oxidant, has a rejuvenating effects on cells or tissues, it is anti-aging hence can contribute substantially on the fertility effect of this plant. Alkaloids and tannins may also contribute to the plant's effects as antimalarial, anti-diarrhea and analgesic agents.…”

Section: Resultsmentioning

confidence: 99%

“…It is locally called Iyin-olobe (Yoruba, south-west Nigeria) (Adeneye et al, 2006) or kidney stone plant. In Traditional medicine, it is used for its hepatoprotective , antidiabetic, antihypertensive, analgesic, anti-inflammatory and antimicrobial properties (Adeneye et al, 2006).The plant is also used in the treatment of stomach disorders, skin diseases and cold (Kokwaro, 1976, Iwu,1993. It has antidiarrheal effect (Odetola and Akojenu 2000).…”

mentioning

confidence: 99%

“…Its anti-viral activity against hepatitis B virus has been established (Thyagarajan et al, 1988;Meixa et al 1995); anticarcinogenic (Joy and kutten, 2000) and antimutagenic activities (Joy and Kutten, 1998). It also has anti-nociceptive and anti-inflammatory activities (kassuya et al, 2003), antidiabetic and antilipidemic potentials (Adeneye et al ,2006). So far, there is no report on the effects of Phyllanthus amarus on hormomal parameters, such as Testosterone, Follicle stimulating and Leutenizing hormones.…”

mentioning

confidence: 99%

See 2 more Smart Citations

The Phytochemical constituents and the effects of methanol extracts of<i> Phyllanthus amarus</i> leaves (kidney stone plant) on the hormonal parameters of Male guinea pigs.

Obianime¹,

Uche²

2010

Journal of Applied Sciences and Environmental Management

View full text Add to dashboard Cite

ABSTRACT:The effects of the methanolic extracts of the leaves of Phyllanthus amarus on the hormonal parameters of male Guinea pigs were investigated. The phytochemical screening of the leaves of Phyllanthus amarus was also carried out. The hormonal parameters investigated are testosterone, Leutinizing and Follicle stimulating hormone. The methanolic extract of the Phyllanthus amarus leaves (50-800mg/kg) caused a statistically significance increase ( P < 0.001, ANOVA) in the level of Testosterone of the male Guinea pigs, from 2.3 ± 0.06 to 3.9 ± 0.05, 4.3 ± 0.6 and 2.8 ± 0.6 after the 7, 14 th and 21 st day of the administration of the extracts respectively . The highest increase was obtained after 14 th day of treatment (4.3 ±.05). These effects were very comparable to the effects of Vitamin E on the testosterone of male Guinea pigs, which were obtained to be 3.0 ± 0.01, 3.1 ± 0.16 and 2.4 ± 0.30 for 7, 14 th and 21 st day respectively. These effects were dose-and time-dependents. The optimum effects (4.3 ±.05) were obtained at 400mg/kg of Phyllanthus amarus. Furthermore, the methanol extracts of Phyllanthus amarus (800mg/kg) caused an insignificant change in the levels of Leutenizing (LH) and Follicle stimulating (FSH) hormones from 3.1±0.22 and 1.6±0.50 to 3.0 ±0.08 and 1.5 ± 0.13 respectively. These effects were also comparable to the effects of Vitamin E on these hormones. Finally, the phytochemical screening of the leaves of Phyllanthus amarus revealed the presence of flavonoids, tannins, alkaloids, terpenoids, steroids, saponins and cardiac glycosides. This may support or justify the claims on the use of the aerial part of this plant by traditional medicine practitioners to increase/improve libido and reproductive function in men. Although further studies need to be done to investigate the contribution of the seeds of this plant in the improvement of libido in men; also to isolate and characterize the active principles in the leaf extracts. @ JASEM

show abstract

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

The Phytochemical constituents and the effects of methanol extracts of<i> Phyllanthus amarus</i> leaves (kidney stone plant) on the hormonal parameters of Male guinea pigs.

Obianime¹,

Uche²

2010

Journal of Applied Sciences and Environmental Management

View full text Add to dashboard Cite

show abstract

“…In response to the global health challenge, the WHO expert Committees on diabetes and on arterial hypertension that recommended further evaluation of the folkloric methods of managing the two diseases, we had identified and evaluated their treatment from their signs, symptoms and complications in traditional medicine; because of high mortality and morbidity arising from their attendant complications and the draw-backs associated with the use of conventional hypoglycemic and hypotensive drugs [7,8].…”

Section: Introductionmentioning

confidence: 99%

Ethnomedical and Ethnopharmacological Study of Plants Used For Potential Treatments of Diabetes and Arterial Hypertension by Indigenous People in Three Phytogeographic Regions of Cameroon

Tsabang¹,

Lionel²,

Cedrix³

et al. 2017

Diabetes Case Rep

View full text Add to dashboard Cite

“…It is commonly called "iyin olobisowo" in yoruba and said to possess claims of medicinal values which include hepatoprotective, anti-diabetic, anti-hypertensive, analgesic, anti-inflammatory and anti-microbial properties (Adeneye et al, 2006;Okiki et al, 2015). Chemical compounds including alkaloids, flavonoids, lignans and phenols have been reportedly isolated from this plant (Adeneye et al, 2006). However, the antiviral potentials of this plant have not been exhaustively explored.…”

Section: Introductionmentioning

confidence: 99%

In-ovo biological activities of Phyllanthus amarus leaf extracts against Newcastle disease virus

Faeji¹,

Oladunmoye²,

Adebayo³

et al. 2017

J. Med. Plants Res.

View full text Add to dashboard Cite

Newcastle disease virus is a paramyxovirus which causes Newcastle disease in birds. Investigation was done on the effect of leaf extract of Phyllanthus amarus against Newcastle disease virus (NDV) using an in-ovo assay. Nine to eleven day-old viable embryonated chicken eggs (ECE) were used for the assay, these were divided into six groups of six eggs each. Methanol, aqueous and n-hexane extracts of the plant leaves were administered to the various groups at concentrations varying from 50 to 5 mg/ml. Embryonated eggs were incubated and embryo survival was monitored daily. Negative control and diluents control groups received phosphate buffer saline (PBS) and dimethly suphoxide (DMSO), respectively. The other group was uninoculated while a virus control group received 100 EID 50 /0.1 ml NDV alone. Bacteria free allantoic fluid from the embryonated eggs in different treatment groups were harvested and collected for spot hemagglutination (HA) test and HA assay to detect the presence of NDV viral particles and the viral titre, respectively. Leaf extracts were assayed for presence of phytochemicals and antioxidant potentials. It was observed from the results that the extract was toxic to the embryo at a concentration above 50 mg/ml and further results showed that the HA viral titre reduction was directly proportional to increasing extract concentration. The phytochemical assays of leaf extract revealed the presence of phytochemicals including alkaloids, tannins, saponins, flavonoids, phenols, steroids, glycosides. The current findings have demonstrated that leaf extract from P. amarus has potentials of medicinal value as well as antiviral activity against NDV in-ovo. Further experimental assays using live animal models are recommended to validate the use of P. amarus plant extract in therapeutic measure in chickens.

show abstract

Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice

Cited by 86 publications

References 1 publication

The Phytochemical constituents and the effects of methanol extracts of<i> Phyllanthus amarus</i> leaves (kidney stone plant) on the hormonal parameters of Male guinea pigs.

The Phytochemical constituents and the effects of methanol extracts of<i> Phyllanthus amarus</i> leaves (kidney stone plant) on the hormonal parameters of Male guinea pigs.

Ethnomedical and Ethnopharmacological Study of Plants Used For Potential Treatments of Diabetes and Arterial Hypertension by Indigenous People in Three Phytogeographic Regions of Cameroon

In-ovo biological activities of Phyllanthus amarus leaf extracts against Newcastle disease virus

Contact Info

Product

Resources

About