Hypoglycemic and anti-inflammatory effects of seabuckthorn seed protein in diabetic ICR mice

Yuan, Huaibo; Zhu, Xiping; Wang, Wenjuan; Li, Meng; Chen, Deyi; Cuan, Zhang

doi:10.1039/c5fo01600b

Cited by 29 publications

(19 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(2016). [ 56 ] This corresponds to an equivalent daily dose of 17.82 mg kg −1 d −1 in a human according to the method published in the Methodology of Pharmacological Experiment. [ 57 ] Simply put, the dose translation is based on the body surface area.…”

Section: Methodsmentioning

confidence: 99%

“…Dosage Information: Protein isolates were administrated by gavage once a day for 5 weeks and the dose (200 mg kg −1 d −1 ) was set up according to Yuan et al (2016). [56] This corresponds to an equivalent daily dose of 17.82 mg kg −1 d −1 in a human according to the method published in the Methodology of Pharmacological Experiment. [57] Simply put, the dose translation is based on the body surface area.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Protein Isolates from Raw and Cooked Foxtail Millet Attenuate Development of Type 2 Diabetes in Streptozotocin‐Induced Diabetic Mice

Yin

Guo

et al. 2021

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope Millet protein has received much attention due to its beneficial role in alleviating metabolic disease symptoms. This study aims to investigate the role and molecular mechanism of foxtail millet protein isolates, including protein isolates from raw and cooked foxtail millet in alleviating diabetes, including gut microbiota and intracellular signal pathways. Methods and results Protein isolates from raw and cooked foxtail millet are orally administered to streptozotocin (STZ)‐induced diabetic mice for 5 weeks before hypoglycemic effect evaluation. The results show that foxtail millet protein isolates improve glucose intolerance and insulin resistance in diabetic mice. However, only the protein isolate from cooked foxtail millet reverse the weight loss trend and alleviate lipid disorders in diabetic mice. Besides, 16S rRNA sequencing show that both raw and cooked foxtail millet protein isolates altered diabetes‐induced gut dysbiosis. In addition, western blotting analysis indicated that the protein isolate from cooked foxtail millet increases the expression levels of glucagon‐like peptide‐1 receptor (GLP‐1R), phosphoinositide 3‐kinase (PI3K), and phosphoinositide‐protein kinase B (p‐AKT)/AKT while the protein isolate from raw foxtail millet downregulates stearoyl‐coenzyme A desaturase 1 (SCD1) level. Conclusion Both raw and cooked foxtail millet protein isolates can exert hypoglycemic effects in diabetic mice through rewiring glucose homeostasis, mitigating diabetes‐induced gut dysbiosis, and affecting the GLP‐1R/PI3K/AKT pathway.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Protein Isolates from Raw and Cooked Foxtail Millet Attenuate Development of Type 2 Diabetes in Streptozotocin‐Induced Diabetic Mice

Yin

Guo

et al. 2021

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…These compounds are abundant in nature and are found in vegetables, fruits, legumes, cereals, and seeds of different plant species [ 6 ]. In the literature, they are also known as polyphenols with potent biological activities, including anti-carcinogenic, antimicrobial, antiviral, anti-inflammatory, anti-allergic, antimutagenic, and antihyperglycemic effects; they also help to prevent obesity and heart disease problems [ 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Procyanidins: From Agro-Industrial Waste to Food as Bioactive Molecules

Valencia-Hernández

Wong-Paz

Ascacio-Valdés

et al. 2021

Foods

View full text Add to dashboard Cite

Procyanidins are an important group of bioactive molecules known for their benefits to human health. These compounds are promising in the treatment of chronic metabolic diseases such as cancer, diabetes, and cardiovascular disease, as they prevent cell damage related to oxidative stress. It is necessary to study effective extraction methods for the recovery of these components. In this review, advances in the recovery of procyanidins from agro-industrial wastes are presented, which are obtained through ultrasound-assisted extraction, microwave-assisted extraction, supercritical fluid extraction, pressurized fluid extraction and subcritical water extraction. Current trends focus on the extraction of procyanidins from seeds, peels, pomaces, leaves and bark in agro-industrial wastes, which are extracted by ultrasound. Some techniques have been coupled with environmentally friendly techniques. There are few studies focused on the extraction and evaluation of biological activities of procyanidins. The identification and quantification of these compounds are the result of the study of the polyphenolic profile of plant sources. Antioxidant, antibiotic, and anti-inflammatory activity are presented as the biological properties of greatest interest. Agro-industrial wastes can be an economical and easily accessible source for the extraction of procyanidins.

show abstract

“…Those are flavonoids, carotenoids, steroids (erogosterol, stigmasterol, lanosterols, and amyrins), vitamins C, E and K, fatty acid, and some essential amino acids (Rousi et al, 1971;Beveridge et al, 1999;Srivastava et al, 2013;Guliyev et al, 2004). These compounds have beneficial effects on human health, such as anti-atherogenic, antioxidant, anti-cancer, and anti-bacterial effects (Suomelaet al, 2006;Yuan et al, 2016;Wang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effects of sea-buckthorn leaves on performance and serum metabolic profiles in Altay lambs

Liu¹,

Niu²,

Tang³

et al. 2019

SA J. An. Sci.

View full text Add to dashboard Cite

In this study, the effects of sea-buckthorn (Hippophae rhamnoides L.) leaves (SL) on the biochemical parameters and metabolomic profiling in Altay lamb (Ovis aries) were observed. Sixty six-month-old male Altay lambs (body weight 28.0 ± 3.5 kg) were randomly assigned to four groups (n=15). The experimental groups were named as CON, 2.5%, 5.0% and 7.5%. The group CON, contained animals fed with a basal diet. Animals of the other groups were fed a treatment diet consisting of 2.5% (Group 2.5%), 5.0% (Group 5.0%) and 7.5% (Group 7.5%) SL. The experimental period lasted 56 days. The results showed that the average daily gain (ADG) and average daily feed intake (ADFI) increased with the increase in the levels of dietary SL. Dietary SL showed a direct relationship with total protein (TP), albumin, globulin and total cholesterol (TC) content of the experimental animals. However, an indirect relationship was observed between dietary SL and the concentration of urea nitrogen (UN). The concentrations of glucose, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) showed quadratic change. Additional changes occurred in the endogenous metabolites involving multiple pathways. The pathways were tricarboxylic acid (TCA) cycle, the metabolism of protein and amino acid and the metabolism of fatty acid and steroid. The changes in metabolites primarily revealed an increase in amino acids and carbohydrates and a decrease in lipid metabolites. These findings provide a comprehensive insight into the effects of the metabolic aspects of sea-buckthorn leaves on Altay lambs. In addition, the present research results provide a better understanding to the development and utilization of sea-buckthorn as a healthy additive for small ruminant production.

show abstract

Hypoglycemic and anti-inflammatory effects of seabuckthorn seed protein in diabetic ICR mice

Cited by 29 publications

References 18 publications

Protein Isolates from Raw and Cooked Foxtail Millet Attenuate Development of Type 2 Diabetes in Streptozotocin‐Induced Diabetic Mice

Protein Isolates from Raw and Cooked Foxtail Millet Attenuate Development of Type 2 Diabetes in Streptozotocin‐Induced Diabetic Mice

Procyanidins: From Agro-Industrial Waste to Food as Bioactive Molecules

Effects of sea-buckthorn leaves on performance and serum metabolic profiles in Altay lambs

Contact Info

Product

Resources

About