Hypoglycemic and anti-inflammatory effects of Psacalium paucicapitatum corms infusions

Rodríguez, Diana Jasso de; García-Hernández, L.C.; Rocha‐Guzmán, Nuria Elizabeth; Moreno‐Jiménez, Martha Rocío; Rodrı́guez-Garcı́a, R.; Díaz-Jiménez, M.L.V.; Flores-López, María L.; Quintanilla, José Ángel Villarreal; Peña-Ramos, Fidel Maximiano; Carrillo-Lomelí, D.A.

doi:10.1016/j.indcrop.2017.04.022

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…The latter situates it as a highly interesting species in the area of investigation in DM, due to this integral and candidate effect in later studies. In the same fashion, another species belonging to the same genus, P. paucicapitatum , a species endemic to Mexico, exhibited anti-inflammatory properties and a hypoglycemic effect in vivo on C57BL/6 mice when the aqueous extract with fructooligosaccharide content was evaluated [ 176 ].…”

Section: Discussionmentioning

confidence: 99%

Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules of Psacalium decompositum (A. Gray) H. Rob & Brettell

et al. 2021

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Diabetes mellitus (DM) is cited as a serious worldwide health problem that occupies second place in causes of annual mortality in Mexico. Among Mexican flora, nearly 300 plant species have been employed as hypoglycemic in popular use. Thus, their study entertains great relevance In this context, this work contributes a clear and timely review of the plant species utilized in Traditional Mexican Medicine and experimental biological models in which not only have the hypoglycemic properties of the extracts and the isolated compounds been considered, but also the anti-inflammatory and antioxidant properties, taking into account an integral focus based on the complex mechanisms involved in the pathogenesis and physiopathology of DM. Among the species reviewed, we highlight Psacalium decompositum (Asteraceae), due to the potent hypoglycemic, anti-inflammatory, and antioxidant activity of the sesquiterpenes identified as majority compounds isolated from the root, such as cacalol and cacalone that also possess the capacity of increasing insulin levels. In this manner, the present manuscript attempts to contribute necessary information for the future study of bioactive molecules that are useful in the treatment of DM, as well as also being a contribution to the knowledge and diffusion of Mexican Traditional Medicine.

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Section: Discussionmentioning

confidence: 99%

Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules of Psacalium decompositum (A. Gray) H. Rob & Brettell

et al. 2021

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“…Under normal skin conditions, the cytokine IL-1β is expressed at low levels in the epidermis of the skin [13]. IL-1β stimulates monocytes and macrophages to produce higher levels of other cytokines that can trigger nuclear factors, such as activators of gene transcription, and trigger an enzyme pathway that turns on prostaglandin activation [14].…”

Section: Discussionmentioning

confidence: 99%

Wound healing properties of Gliricidia sepium leaves from Indonesia and the Philippines in rats (Rattus norvegicus)

et al. 2021

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Background and Aim: Gliricidia sepium is a medium-sized leguminous plant found widely in tropical to subtropical areas. It has been used as a medicinal ingredient and in rodenticides by local communities in both Indonesia and the Philippines. This study aimed to investigate the wound healing effects of an ointment containing G. sepium leaves on inflammatory cells using a rat model. We also determined its effect on the expression of interleukin (IL) 6 and IL-1β. Materials and Methods: We used 16 Wistar male rats aged approximately 2 months and weighing 150-200 g. They were divided into four treatment groups (T1, positive control; T2, negative control; T3, wounds treated with G. sepium from Indonesia; and T4, wounds treated with G. sepium from the Philippines), and the ointment therapies were applied to wounds for 3 days. Hematoxylin and eosin staining was performed to examine the inflammatory cells microscopically. IL-1β and IL-6 expression were observed immunohistochemically. Results: G. sepium leaves significantly (p<0.05) decreased the number of inflammatory cells, and the expression of IL-1β and IL-6 in the group treated with Indonesian G. sepium leaves was higher than that in the group treated with G. sepium leaves from the Philippines. The leaves contain flavonoids, saponins, and tannins, which act as anti-inflammatory agents to enhance the wound healing process. Conclusion: Our findings suggest that G. sepium leaves from both the Philippines and Indonesia possess wound healing properties.

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“…The Rm fruit extracts were obtained according to Jasso de Rodríguez et al [18] with slight changes. To an 11.5 g of dried fruit were poured 125 mL of distilled water or hydro-alcohol solution (50:50 v/v), and exhaustively extracted at 150 rpm for 22 h at room temperature (Innova 44 Incubator, New Brunswick Scientific Co., Inc., Edison, NJ, USA).…”

Section: Preparation Of Rhus Microphylla (Rm) Fruit Extractsmentioning

confidence: 99%

Edible Films Based on Black Chia (Salvia hispanica L.) Seed Mucilage Containing Rhus microphylla Fruit Phenolic Extract

et al. 2020

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Functional films based on black chia (Salvia hispanica L.) seed mucilage (BCm) containing Rhus microphylla (Rm) fruit phenolic extract were built and characterized. A hydro-alcohol extract (HAE) of Rm was incorporated as the bioactive agent due to its noteworthy phenolic profile, and good antioxidant and antifungal activities. The effects of the BCm concentration (0.2% and 0.4%, w/v), HAE incorporation, and their interaction with glycerol (1.0%, w/v) and calcium chloride (0.05%, w/v) on the films’ physicochemical properties were evaluated. The filmogenic solutions successfully fitted to the Herschel–Bulkley model (R2 < 0.999), exhibiting a pseudoplastic and shear thinning character, typical of polymer solutions. Interestingly, their rheological properties were not (p > 0.05) changed by the HAE addition, but their surface tension was enhanced (p < 0.05), which could favor their coating ability. The polyanionic nature of the systems (zeta potential-Zp values from −26.9 to −33.3 mV) allowed them to interact with Ca2+ cations, thus forming stable and resistant films. All the films showed low water solubility (15.0% to 22.3%) and high permeability (3.7 to 4.0 × 10−10 g m−1 s−1 Pa−1), as well as high biodegradability (moisture content from 66.0% to 80.9%); although the moisture content was reduced (p < 0.05) with HAE addition. The combination of higher BCm ratio and HAE addition (BCm0.4+Rm) led to a more resistant, thick, opaque, and dark film compared with the others obtained. This study reveals the BCm-based films’ potential, highlighting those with HAE, representing a novel alternative to improve the quality of food products.

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Hypoglycemic and anti-inflammatory effects of Psacalium paucicapitatum corms infusions

Cited by 7 publications

References 37 publications

Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules of Psacalium decompositum (A. Gray) H. Rob & Brettell

Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules of Psacalium decompositum (A. Gray) H. Rob & Brettell

Wound healing properties of Gliricidia sepium leaves from Indonesia and the Philippines in rats (Rattus norvegicus)

Edible Films Based on Black Chia (Salvia hispanica L.) Seed Mucilage Containing Rhus microphylla Fruit Phenolic Extract

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